公开(公告)号：EP2438078A1

公开(公告)日：2012-04-11

申请号：EP10744355.8

申请日：2010-02-19

申请人： UNIVERSITY OF KANSAS

发明人： BLAGG, Brian, S. ,  ZHAO, Huiping ,  DONNELLY, Alison, Catherine

IPC分类号： C07H17/06

CPC分类号： C07H17/06 ,  C07D311/16 ,  C07D405/12 ,  C07D405/14 ,  C07H17/075

摘要： The disclosure provides novobiocin analogues with noviose replacements which are useful as Hsp90 inhibitors in the treatment of cancer.

公开(公告)号：EP1807440B1

公开(公告)日：2020-02-19

申请号：EP05824355.1

申请日：2005-11-03

申请人： The University of Kansas ,  Department of Health and Human Services

发明人： BLAGG, Brian, S. ,  NECKERS, Len ,  YU, Xiao, Ming

IPC分类号： C07H17/075 ,  A61K31/7048 ,  A61P35/00 ,  A61P25/00

公开(公告)号：EP2438078B1

公开(公告)日：2017-10-25

申请号：EP10744355.8

申请日：2010-02-19

申请人： UNIVERSITY OF KANSAS

发明人： BLAGG, Brian, S. ,  ZHAO, Huiping ,  DONNELLY, Alison, Catherine

IPC分类号： C07H17/06 ,  C07H17/075

CPC分类号： C07H17/06 ,  C07D311/16 ,  C07D405/12 ,  C07D405/14 ,  C07H17/075

公开(公告)号：EP1807440A2

公开(公告)日：2007-07-18

申请号：EP05824355.1

申请日：2005-11-03

申请人： THE UNIVERSITY OF KANSAS ,  Department of Health and Human Services

发明人： BLAGG, Brian, S. ,  NECKERS, Len ,  YU, Xiao, Ming

IPC分类号： C07H17/06

CPC分类号： C07H17/075

摘要： Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.