公开(公告)号：EP1837024A2

公开(公告)日：2007-09-26

申请号：EP07110507.6

申请日：2002-01-11

申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  Auburn University

发明人： Boykin, David ,  Tidwell, Richard R. ,  Stringfellow, David ,  Brock, Kenny ,  Stephens, Chad E. ,  Kumar, Arvind ,  Wilson, W. David ,  Givens, Daniel ,  Dykstra, Christine

IPC分类号： A61K31/505

CPC分类号： C07D405/10 ,  C07D207/337 ,  C07D277/30 ,  C07D307/54 ,  C07D333/24

摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of virtases. Compounds of the present invention will have a structure according to Formulas (I) - (VI) as recited throughout the application.

摘要翻译： 本发明涉及新的化合物和方法可用于治疗黄病毒科的virtases的那样成员有用的。 本发明的化合物将具有雅鼎的结构式（I） - 如权利整个申请（VI）。

公开(公告)号：EP1837024A3

公开(公告)日：2007-11-14

申请号：EP07110507.6

申请日：2002-01-11

申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. ,  Auburn University

发明人： Boykin, David ,  Tidwell, Richard R. ,  Stringfellow, David ,  Brock, Kenny ,  Stephens, Chad E. ,  Kumar, Arvind ,  Wilson, W. David ,  Givens, Daniel ,  Dykstra, Christine

IPC分类号： C07D405/10 ,  C07D333/24 ,  C07D307/54 ,  C07D277/30 ,  C07D207/32 ,  A61K31/426 ,  A61P1/12 ,  A61P31/12

CPC分类号： C07D405/10 ,  C07D207/337 ,  C07D277/30 ,  C07D307/54 ,  C07D333/24

摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of virtases. Compounds of the present invention will have a structure according to Formulas (I) - (VI) as recited throughout the application.

公开(公告)号：EP1792613A2

公开(公告)日：2007-06-06

申请号：EP06118366.1

申请日：2006-08-03

申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

发明人： Tidwell, Richard R. ,  Boykin, David W. ,  Ismail, Mohamed A. ,  Wilson, W. David ,  White, Elizabeth W. ,  Kumar, Arvind ,  Nanjunda, Rupesh

IPC分类号： A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/443 ,  A61P33/02 ,  A61P35/00 ,  C07D307/68 ,  C07D329/00 ,  C07D405/14 ,  C07D421/14

CPC分类号： A61K31/341 ,  A61K31/33 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/443 ,  C07D345/00 ,  C07D405/14 ,  C07D421/14 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/415

摘要： Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.

摘要翻译： 描述了对结合G-四链体DNA具有高选择性的二价化合物。 几种化合物显示出与G-四链体DNA结合的凹槽，并且与罗氏黑斑病相比体外和体内活性相反。 这些化合物代表用于治疗癌症，疟疾，利什曼原虫和锥虫病的新型药物。

公开(公告)号：EP1792613A3

公开(公告)日：2007-07-25

申请号：EP06118366.1

申请日：2006-08-03

申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

发明人： Tidwell, Richard R. ,  Boykin, David W. ,  Ismail, Mohamed A. ,  Wilson, W. David ,  White, Elizabeth W. ,  Kumar, Arvind ,  Nanjunda, Rupesh

IPC分类号： A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/443 ,  A61P33/02 ,  A61P35/00 ,  C07D307/68 ,  C07D329/00 ,  C07D405/14 ,  C07D421/14

CPC分类号： A61K31/341 ,  A61K31/33 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/443 ,  C07D345/00 ,  C07D405/14 ,  C07D421/14 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/415

摘要： Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.