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1.发明公开Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 审中-公开化合物，方法和组合物用于治疗牛病毒性腹泻病毒的（BVDV）感染和丙型肝炎病毒（HCV）感染
公开(公告)号：EP1837024A2
公开(公告)日：2007-09-26
申请号：EP07110507.6
申请日：2002-01-11
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Auburn University
发明人： Boykin, David , Tidwell, Richard R. , Stringfellow, David , Brock, Kenny , Stephens, Chad E. , Kumar, Arvind , Wilson, W. David , Givens, Daniel , Dykstra, Christine
IPC分类号： A61K31/505
CPC分类号： C07D405/10 , C07D207/337 , C07D277/30 , C07D307/54 , C07D333/24
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of virtases. Compounds of the present invention will have a structure according to Formulas (I) - (VI) as recited throughout the application.
摘要翻译： 本发明涉及新的化合物和方法可用于治疗黄病毒科的virtases的那样成员有用的。 本发明的化合物将具有雅鼎的结构式（I） - 如权利整个申请（VI）。
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2.发明公开Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection 审中-公开化合物，方法和组合物用于治疗牛病毒性腹泻病毒的（BVDV）感染和丙型肝炎病毒（HCV）感染
公开(公告)号：EP1837024A3
公开(公告)日：2007-11-14
申请号：EP07110507.6
申请日：2002-01-11
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Auburn University
发明人： Boykin, David , Tidwell, Richard R. , Stringfellow, David , Brock, Kenny , Stephens, Chad E. , Kumar, Arvind , Wilson, W. David , Givens, Daniel , Dykstra, Christine
IPC分类号： C07D405/10 , C07D333/24 , C07D307/54 , C07D277/30 , C07D207/32 , A61K31/426 , A61P1/12 , A61P31/12
CPC分类号： C07D405/10 , C07D207/337 , C07D277/30 , C07D307/54 , C07D333/24
摘要： The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of virtases. Compounds of the present invention will have a structure according to Formulas (I) - (VI) as recited throughout the application.
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3.发明授权5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双（4-脒基苯基）-2,2'- bifuran衍生物和Erwandte化合物作为抗原生动物和前药的活性物质
公开(公告)号：EP1726589B1
公开(公告)日：2008-10-15
申请号：EP06114189.1
申请日：2006-05-19
申请人： The University of North Carolina at Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
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公开(公告)号：EP1244651A1
公开(公告)日：2002-10-02
申请号：EP00989364.5
申请日：2000-12-20
申请人： The University of North Carolina at Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
IPC分类号： C07D405/04 , C12Q1/68 , A61K31/415 , A61P31/04 , A61P35/00
CPC分类号： C07D207/416 , C07D307/54 , C07D405/04 , C07D405/14 , C12Q1/6816 , C12Q2563/173
摘要： Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.
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5.发明公开5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双 - （4-脒基苯基）-2,2'-联呋喃衍生物和作为抗原虫剂的相关化合物及其前药
公开(公告)号：EP1726589A3
公开(公告)日：2006-12-13
申请号：EP06114189.1
申请日：2006-05-19
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
摘要： Novel dicationic bichalcophene compounds of formula (I) are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
wherein:
X 1 and X 2 are independetly selected from the group consisting of O, S, Se, Te, and NR 1 ,
Ar 1 and Ar 2 are independently selected from the group consisting of phenyl, pyridine, and benzimidazole;
Am 1 and Am 2 are each摘要翻译： 描述了新的式（I）的双阳离子双酚类化合物。 目前公开的新型双阳离子双苯乙烯类化合物相对于喷他脒和呋咱英表现出与布氏罗得西亚罗得西亚虫，恶性疟原虫或杜氏利什曼原虫相比的体外活性。 一些新型双阳离子双酚类化合物在布氏锥虫罗得斯菌感染的小鼠模型中显示出良好的体内活性。 其中：X 1和X 2独立地选自O，S，Se，Te和NR 1，Ar 1和Ar 2独立地选自由苯基，吡啶和苯并咪唑组成的组; Am1和Am2都是
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6.发明公开5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双 - （4-脒基苯基）-2,2'-Bifuran衍生物和Erwandte Verbindungen als Wirkstoffe gegen Protozen und Prodrugs
公开(公告)号：EP1726589A2
公开(公告)日：2006-11-29
申请号：EP06114189.1
申请日：2006-05-19
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
摘要： Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
摘要翻译： 描述了式（I）的新型双阳离子双生烯烃化合物。 目前公开的新型双阳离子双生命烯化合物显示体外活性与罗氏黑斑病，恶性疟原虫或杜氏不动症相当，与戊脒和呋脒相当。 一些新型双阳离子双生命烯化合物在罗氏黑斑病感染的鼠模型中在体内表现出良好的活性。 其中：X 1和X 2独立地选自O，S，Se，Te和NR 1，Ar 1和Ar 2独立地选自苯基，吡啶和苯并咪唑; Am 1和Am 2各自
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7.发明公开Linear dicationic terphenyls and their aza analogues as antiparasitic agents 审中-公开Lineare dikationische Terphenyle和ihar Azaanaloga alsantiparasitäreMittel
公开(公告)号：EP1949896A2
公开(公告)日：2008-07-30
申请号：EP08150205.6
申请日：2008-01-14
申请人： The University of North Carolina At Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , Arafa, Reem K. , Hu, Laixing
IPC分类号： A61K31/155 , C07C257/18 , C07C259/18 , C07C279/18 , C07D213/58 , C07D213/26 , C07D213/28 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/14 , C07D307/46 , C07D307/52 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , A61P33/00
CPC分类号： C07C257/18 , C07C259/18 , C07C279/18 , C07C279/24 , C07D213/58 , C07D239/26 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
L 1 -Ar 1 -(CH 2 ) p -Ar 2 -(CH 2 ) q -Ar 3 -L 2 (I)摘要翻译： 新型双阳离子三联苯化合物及其杂环类似物。 用新型双阳离子三联苯化合物及其氮杂类似物对抗微生物感染的方法。 合成新型双线性三联苯化合物及其氮杂类似物的方法。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒL1 -Ar 1 - （CH 2）p -Ar 2 - （CH 2）q -Ar 3 -L 2€ƒ€ƒ€ƒ€ ƒ（I）
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8.发明公开Dicationic compounds which selectively recognize G-quadruplex DNA 审中-公开Dicationische Verbindungen死于selektiv G-Quadruplex-DNA erkennen
公开(公告)号：EP1792613A2
公开(公告)日：2007-06-06
申请号：EP06118366.1
申请日：2006-08-03
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , White, Elizabeth W. , Kumar, Arvind , Nanjunda, Rupesh
IPC分类号： A61K31/33 , A61K31/341 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/443 , A61P33/02 , A61P35/00 , C07D307/68 , C07D329/00 , C07D405/14 , C07D421/14
CPC分类号： A61K31/341 , A61K31/33 , A61K31/381 , A61K31/4164 , A61K31/4184 , A61K31/443 , C07D345/00 , C07D405/14 , C07D421/14 , Y02A50/409 , Y02A50/411 , Y02A50/415
摘要： Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus Trypanosoma brucei rhodesiense. The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.
摘要翻译： 描述了对结合G-四链体DNA具有高选择性的二价化合物。 几种化合物显示出与G-四链体DNA结合的凹槽，并且与罗氏黑斑病相比体外和体内活性相反。 这些化合物代表用于治疗癌症，疟疾，利什曼原虫和锥虫病的新型药物。
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公开(公告)号：EP1244651B1
公开(公告)日：2006-11-22
申请号：EP00989364.5
申请日：2000-12-20
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
IPC分类号： C07D405/04 , C12Q1/68 , A61K31/415 , A61P31/04 , A61P35/00
CPC分类号： C07D207/416 , C07D307/54 , C07D405/04 , C07D405/14 , C12Q1/6816 , C12Q2563/173
摘要： Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.
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10.发明公开Linear dicationic terphenyls and their aza analogues as antiparasitic agents 审中-公开线性双阳离子三联苯和它们作为抗寄生虫药氮
公开(公告)号：EP1949896A3
公开(公告)日：2008-08-06
申请号：EP08150205.6
申请日：2008-01-14
申请人： The University of North Carolina At Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , Arafa, Reem K. , Hu, Laixing
IPC分类号： A61K31/155 , C07C257/18 , C07C259/18 , C07C279/18 , C07D213/58 , C07D213/26 , C07D213/28 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/14 , C07D307/46 , C07D307/52 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , A61P33/00
CPC分类号： C07C257/18 , C07C259/18 , C07C279/18 , C07C279/24 , C07D213/58 , C07D239/26 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
L 1 -Ar 1 -(CH 2 ) p -Ar 2 -(CH 2 ) q -Ar 3 -L 2 (I)
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