专利检索 ap:("UNIVERSITY OF ROCHESTER") AND inv:"SOWDEN, Mark, P." 第 1 页

1.

发明授权
METHODS AND COMPOSITIONS FOR MODIFYING APOLIPOPROTEIN B mRNA EDITING 有权
标题翻译：方法和组合物的变更处理载脂蛋白B mRNA的

公开(公告)号：EP1392846B1

公开(公告)日：2008-06-11

申请号：EP02731102.6

申请日：2002-02-26

申请人： UNIVERSITY OF ROCHESTER

发明人： SMITH, Harold, C. , YANG, Yan , SOWDEN, Mark, P.

IPC分类号： C12N15/62 , C12N15/52 , C12N15/63 , C12N9/78 , C07K14/47 , C07K19/00 , C12N5/10 , A61K38/17 , A61K38/50

CPC分类号： C12N9/78 , A61K38/00 , C07K2319/00

摘要： Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or niosome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.

2.

发明公开
PROTEIN TRANSDUCING DOMAIN/DEAMINASE CHIMERIC PROTEINS, RELATED COMPOUNDS, AND USES THEREOF 审中-公开
标题翻译：嵌合蛋白FROM PROTEINTRANSDUZIERENDER DOMAIN /脱氨酶，相关化合物及其用途

公开(公告)号：EP1575992A2

公开(公告)日：2005-09-21

申请号：EP03767199.7

申请日：2003-08-05

申请人： UNIVERSITY OF ROCHESTER

发明人： SMITH, Harold, C. , SOWDEN, Mark, P. , DEWHURST, Stephen , KIM, Baek , WEDEKIND, Joseph

IPC分类号： C07K1/00

CPC分类号： C12N9/1205 , C07K2319/10 , C12N9/6429 , C12N9/78 , C12N15/62 , C12Y304/21005

摘要： Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.

3.

发明公开
METHODS AND COMPOSITIONS FOR MODIFYING APOLIPOPROTEIN B mRNA EDITING 有权
标题翻译：方法和组合物的变更处理载脂蛋白B mRNA的

公开(公告)号：EP1392846A2

公开(公告)日：2004-03-03

申请号：EP02731102.6

申请日：2002-02-26

申请人： University of Rochester

发明人： SMITH, Harold, C. , YANG, Yan , SOWDEN, Mark, P.

IPC分类号： C12Q1/00

CPC分类号： C12N9/78 , A61K38/00 , C07K2319/00

摘要： Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or niosome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.

4.

发明公开
CYTIDINE DEAMINASE ACTIVATORS, DEOXYCYTIDINE DEAMINASE ACTIVATORS, VIF ANTAGONISTS, AND METHODS OF SCREENING FOR MOLECULES THEREOF 审中-公开
标题翻译：胞苷脱氨酶激活剂，脱氧胞苷脱氨酶激活剂，VIF拮抗剂和筛选及其方法分子

公开(公告)号：EP1670895A2

公开(公告)日：2006-06-21

申请号：EP04788573.6

申请日：2004-09-03

申请人： UNIVERSITY OF ROCHESTER

发明人： SMITH, Harold, C. , WEDEKIND, Joseph, E. , SOWDEN, Mark, P. , DEWHURST, Stephen , KIM, Baek

IPC分类号： C12N1/00

CPC分类号： G01N33/56988 , C12Y305/04005 , C12Y305/04014 , G01N2333/16 , G01N2333/978 , G01N2500/04

摘要： Disclosed are compounds that enhance RNA or DNA editing, as well as methods of using, identifying, and making such compounds. These compounds include Vif antagonists and cytidine deaminase inhibitors.