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公开(公告)号：EP2043607A2
公开(公告)日：2009-04-08
申请号：EP07849670.0
申请日：2007-06-22
申请人： USV Limited
发明人： TARUR, Venkatasubramanian, Radhakrishnan , SATHE, Dhananjay, Govind , MANTRIPRAGADA, Narayana, Rao , SAWANT, Kamlesh, Digambar , THOOVARA, Sasi, Kumar, Mohan , RANE, Bhupendra, Shaligram
摘要： The present invention relates to process for preparing micronized Valsartan with particle size distribution of d10 less than 5μ, d50 less than 10 μ and d90less than 20 μ preferably d90
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2.发明公开RAPID RESOLUTION PROCESS FOR CLOPIDOGREL BASE AND A PROCESS FOR PREPARATION OF CLOPIDOGREL BISULFATE POLYMORPH - FORM I 审中-公开氯吡格雷-BASE和方法，光隔快速制造方法CLOPIDOGRELBISULFATPOLYMORPHFORM我
公开(公告)号：EP1848720A1
公开(公告)日：2007-10-31
申请号：EP05747156.7
申请日：2005-02-15
申请人： USV LIMITED
发明人： TARUR, Venkatasubramanian, Radhakrishnan , SATHE, Dhananjay, Govind , SAWANT, Kamlesh, Digambar , MONDKAR, Harish, Kashinath , DESHPANDE, Manoj, Madhukarrao Indrayani Niwas , NAIK, Tushar, Anil
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.
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3.发明公开A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE 4-AMINO-1-ISOBUTYL-1H-IMIDAZOÝ4,5-C¨-QUINOLINE (IMIQUIMOD) 审中-公开METHOD FOR PRODUCING基本上纯的4-氨基-1-异丁基-1H-咪唑并[4,5-c]喹啉（咪喹莫特）
公开(公告)号：EP1831219A2
公开(公告)日：2007-09-12
申请号：EP05850947.2
申请日：2005-12-23
申请人： USV LIMITED
发明人： TARUR, Venkatasubramanian Radhakrishnan, USV Limited , KADAM, Suresh Mahadev, USV Limited , JOSHI, Anil Purushottam, USV Limited , GAVHANE, Sachin Baban, USV Limited , SAWANT, Kamlesh, Digambar , SATHE, Dhananjay, Govind , NAIK, Tushar, Anil , WADHAWA, Gurmeet, Chandramohan, Swatantra Sainik
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A process for preparation of Imiquimod comprising oxidation of 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline (II) afforded 1-Isobutyl-1H- imidazo-[4,5-c]-quinoline-5-N-oxide(III) which is isolated in pure form as its hydrochloride salt (IV) followed by conversion to 4-chloro derivative(V) and conversion to corresponding 4-iodo derivative (VI) which is a novel intermediate. This novel intermediate is converted to imiquimod (VIII) and purified via its organic salt. The invention also relates to crystalline polymorphic forms of Imiquimod Maleate, Fumarate and Oxalate.
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