公开(公告)号：EP3325479B1

公开(公告)日：2020-12-02

申请号：EP16804541.7

申请日：2016-06-03

申请人： UWM Research Foundation, Inc. ,  Medical University Of Vienna ,  National Taiwan University ,  University of Belgrade-Faculty of Pharmacy

发明人： CHIOU, Lih-Chu ,  COOK, James ,  ERNST, Margot ,  FAN, Pi-Chuan ,  KNUTSON, Daniel ,  MEIRELLES, Matheus ,  MIHOVILOVIC, Marko ,  SIEGHART, Werner ,  VARAGIC, Zdravko ,  VERMA, Ranjit ,  WIMMER, Laurin ,  WITZIGMANN, Christopher ,  SIEBERT, David, Chan Bodin ,  SAVIC, Miroslav, M.

IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D491/147 ,  C07D495/14 ,  C07D498/14 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439 ,  A61P25/24 ,  A61P25/06 ,  A61P25/18 ,  A61P27/16

公开(公告)号：EP3325479A1

公开(公告)日：2018-05-30

申请号：EP16804541.7

申请日：2016-06-03

申请人： UWM Research Foundation, Inc. ,  Medical University Of Vienna ,  National Taiwan University ,  University of Belgrade-Faculty of Pharmacy

发明人： CHIOU, Lih-Chu ,  COOK, James ,  ERNST, Margot ,  FAN, Pi-Chuan ,  KNUTSON, Daniel ,  MEIRELLES, Matheus ,  MIHOVILOVIC, Marko ,  SIEGHART, Werner ,  VARAGIC, Zdravko ,  VERMA, Ranjit ,  WIMMER, Laurin ,  WITZIGMANN, Christopher ,  SIEBERT, David, Chan Bodin ,  SAVIC, Miroslav, M.

IPC分类号： C07D471/04 ,  C07D471/14 ,  C07D401/04 ,  C07D403/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4439

CPC分类号： C07D471/04 ,  A61K31/4745 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P27/16 ,  C07D471/14 ,  C07D491/147 ,  C07D495/14 ,  C07D498/14

摘要： Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.