公开(公告)号：EP3062767A1

公开(公告)日：2016-09-07

申请号：EP14859235.5

申请日：2014-10-30

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： BROWNELL, Lidia, Alfaro ,  CHU, Min ,  CORNELIUSEN, Brandon ,  HONG, Mei-Feng ,  HWANG, Ji-Hye ,  HYUN, Eu-Jin ,  JIA, Qi ,  JIAO, Ping ,  KIM, Mi-Ran ,  LEE, Bo-Su ,  LEE, Young-Chul ,  NAM, Jeong-Bum ,  OH, Mi-Sun ,  YIMAM, Mesfin

IPC分类号： A61K8/49 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K8/97 ,  A61K8/0204 ,  A61K8/36 ,  A61K8/4926 ,  A61K8/4973 ,  A61K2800/42 ,  A61K2800/522 ,  A61K2800/5922 ,  A61Q19/00 ,  A61Q19/06 ,  A61Q19/08

摘要： The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.

公开(公告)号：EP3010928A1

公开(公告)日：2016-04-27

申请号：EP14813460.4

申请日：2014-06-16

申请人： Unigen, Inc. ,  Unigen, Inc.

发明人： BROWNELL, Lidia, Alfaro ,  CHU, Min ,  HONG, Mei-Feng ,  HYUN, Eu-Jin ,  JIA, Qi ,  JIAO, Ping ,  KIM, Hyun-Jin ,  KIM, Mi-Ran ,  KIM, Tae-Woo ,  LEE, Bo-Su ,  LEE, Young-Chul ,  MOORE, Breanna ,  NAM, Jeong-Bum ,  OH, Mi-Sun ,  PARK, Mi-Hye ,  YIMAM, Mesfin ,  ZHANG, Qian

IPC分类号： C07H15/20 ,  C07K14/415 ,  A61K36/605 ,  A61K36/48 ,  A61P19/02

CPC分类号： A61K36/605 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7034 ,  A61K36/48 ,  A61K36/534 ,  A61K2300/00

摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

公开(公告)号：EP4188408A1

公开(公告)日：2023-06-07

申请号：EP21766023.2

申请日：2021-07-29

申请人： Unigen, Inc.

发明人： YIMAM, Mesfin ,  HORM, Teresa ,  BROWNELL, Lidia ,  O'NEAL, Alexandria ,  JIA, Qi

IPC分类号： A61K36/539 ,  A61K31/00 ,  A61K36/48 ,  A61P31/12

公开(公告)号：EP4178601A1

公开(公告)日：2023-05-17

申请号：EP21762827.0

申请日：2021-07-08

申请人： Unigen, Inc.

发明人： YIMAM, Mesfin ,  JIAO, Ping ,  HORM, Teresa ,  BROWNELL, Lidia ,  HONG, Mei ,  O'NEAL, Alexandria ,  JIA, Qi

IPC分类号： A61K36/886 ,  A61K36/076 ,  A61K36/53 ,  A61K31/715 ,  A61K31/05 ,  A61K31/352 ,  A61K31/353 ,  A61K31/4375 ,  A61K36/45

公开(公告)号：EP4100034A1

公开(公告)日：2022-12-14

申请号：EP21708882.2

申请日：2021-02-07

申请人： Unigen, Inc.

发明人： YIMAM, Mesfin ,  JIAO, Ping ,  HORM, Teresa ,  HONG, Mei ,  O'NEAL, Alexandria ,  JIA, Qi

IPC分类号： A61K36/21 ,  A61K36/9062 ,  A61K36/67 ,  A61K36/575 ,  A61P19/02 ,  A61K31/00

公开(公告)号：EP2117532B1

公开(公告)日：2013-03-27

申请号：EP08713667.7

申请日：2008-01-09

申请人： Unigen, Inc.

发明人： ZHAO, Ji-fu ,  TSENG-CRANK, Julie ,  YIMAM, Mesfin ,  JIA, Qi

IPC分类号： A61K31/35

CPC分类号： A61K31/352 ,  A61K31/35 ,  A61K31/7048 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

公开(公告)号：EP4346810A1

公开(公告)日：2024-04-10

申请号：EP22747155.4

申请日：2022-06-03

申请人： Unigen, Inc.

发明人： YIMAM, Mesfin ,  HORM, Teresa ,  JIA, Qi ,  BROWNELL, Lidia ,  JIAO, Ping

IPC分类号： A61K31/423 ,  A61K36/88 ,  A61P25/00

公开(公告)号：EP3373946A1

公开(公告)日：2018-09-19

申请号：EP16831945.7

申请日：2016-11-09

申请人： Unigen, Inc.

发明人： JIAO, Ping ,  JIA, Qi ,  HONG, Mei Feng ,  KIM, Misun

IPC分类号： A61K36/575 ,  A61K36/48 ,  A23L3/3472 ,  A61Q17/00 ,  A61K8/97

CPC分类号： A61K47/46 ,  A23L3/3472 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/922 ,  A61K8/9789 ,  A61K36/48 ,  A61K36/575 ,  A61K2800/10 ,  A61Q17/005 ,  A61Q19/00 ,  A61K2300/00

摘要： Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.

公开(公告)号：EP1503777B1

公开(公告)日：2012-08-22

申请号：EP03733934.8

申请日：2003-05-01

申请人： Unigen, Inc.

发明人： JIA, Qi ,  FARROW, Thomas, M.

IPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/886 ,  A61K36/185 ,  A61K36/704 ,  A61K36/282 ,  A61K36/38 ,  A61K36/48 ,  A61K36/489 ,  A61K36/296 ,  A61P9/10 ,  A61P27/12 ,  A61P25/28 ,  A61P3/10 ,  A61P35/00

CPC分类号： A61K36/48 ,  A61K31/353 ,  A61K31/7034 ,  A61K31/7048 ,  A61K36/185 ,  A61K36/282 ,  A61K36/296 ,  A61K36/38 ,  A61K36/489 ,  A61K36/704 ,  A61K36/886

摘要： The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydroxychrome or a mixture of 7-hydroxychromones. The present invention includes methods that are effective in inhibiting free radical and oxidation caused damage through simultaneous suppression of free radical generation and the suppression of the production of reactive oxygen species (ROS). The present invention also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. The method for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes is comprised of administering to a host in need thereof an effective amount of a composition comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones and a pharmaceutically acceptable carrier. Included in this invention is an improved method to isolate and purify 7-hydroxychromones from plant sources.

公开(公告)号：EP1748767B1

公开(公告)日：2011-12-28

申请号：EP05762186.4

申请日：2005-05-27

申请人： Unigen, Inc. ,  Jia, Qi ,  Zhao, Ji-Fu

发明人： JIA, Qi ,  ZHAO, Ji-Fu

IPC分类号： A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61P17/00 ,  A61P35/00 ,  C07D233/02 ,  C07D323/00

CPC分类号： A61K8/347 ,  A61K8/31 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/015 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/357 ,  A61K31/40 ,  A61K31/704 ,  A61K2800/782 ,  A61Q19/02 ,  C07C39/15 ,  C07C39/367 ,  C07C41/26 ,  C07C41/32 ,  C07C43/23 ,  C07C45/673 ,  C07C49/835 ,  C07C215/74 ,  C07D321/12 ,  Y02A50/406 ,  Y02A50/411

摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.