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公开(公告)号：EP4452417A1
公开(公告)日：2024-10-30
申请号：EP22844175.4
申请日：2022-12-23
发明人： URLINGER, Stefanie , JEKER, Lukas , LEPORE, Rosalba , MATTER MARONE, Romina , CAMUS, Anna , SINOPOLI, Alessandro , DURZYNSKA, Izabela , HAYDN, Anna , DEVAUX, Anna , GARAUDE, Simon
IPC分类号： A61P35/02 , C07K16/28 , C07K14/725 , A61K35/00 , C07K14/705
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公开(公告)号：EP4448573A1
公开(公告)日：2024-10-23
申请号：EP22843648.1
申请日：2022-12-16
发明人： URLINGER, Stefanie , LEPORE, Rosalba , JEKER, Lukas , WIEDERKEHR, Amélie , SINOPOLI, Alessandro , CAMUS, Anna , WELLINGER, Lisa , MATTER-MARONE, Romina
IPC分类号： C07K16/28 , A61K39/00 , A61K35/28 , C12N5/0789 , C12N15/113
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公开(公告)号：EP4380693A1
公开(公告)日：2024-06-12
申请号：EP22762043.2
申请日：2022-08-05
发明人： LEPORE, Rosalba , JEKER, Lukas , URLINGER, Stefanie , LANDMANN, Emmanuelle , SINOPOLI, Alessandro , WIEDERKEHR, Amélie , DEVAUX, Anna , CAMUS, Anna , HAYDN, Anna , MATTER-MARONE, Romina
IPC分类号： A61P35/00 , A61K39/00 , A61P35/02 , C07K14/705 , C07K16/28 , C12N5/0783 , C12N15/113 , A61K35/12 , C07K14/00 , C07K16/00 , C12N5/00 , C12N15/00
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公开(公告)号：EP4360639A3
公开(公告)日：2024-07-17
申请号：EP24155910.3
申请日：2017-10-30
申请人： Universität Basel
发明人： JEKER, LUKAS , BORDOLI SCHWEDE, Lorenza , KORNETE, Mara , SCHWEDE, Torsten , LEPORE, Rosalba , MATTER MARONE, Romina , RECHER, Mike
IPC分类号： C12N15/10 , C12N15/90 , C12Q1/68 , A61K35/12 , C07K14/705
CPC分类号： A61K35/00 , A61K35/12 , C12N2510/0020130101 , A61P35/02 , C07K2319/0320130101 , C12N15/102 , C12N2310/2020170501 , C12N9/22 , C07K14/705 , C12N15/902 , A61K39/4644 , A61K2239/3820230501 , A61K39/4611
摘要： The invention relates to a mammalian cell, particularly a human cell, expressing a first isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from a second isoform, for use in a medical treatment of a patient having cells expressing the second isoform form of the surface protein. The invention further relates to an agent selected from 1) a compound comprising, or consisting of, an antibody or antibody-like molecule and 2) an immune effector cell bearing an antibody-like molecule or an immune effector cell bearing a chimeric antigen receptor, for use in a method of treatment of a medical condition, wherein the agent is specifically reactive to either a first or a second isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from the second isoform, and wherein the agent is administered to ablate a cell bearing the isoform that the agent is reactive to.
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公开(公告)号：EP4360639A2
公开(公告)日：2024-05-01
申请号：EP24155910.3
申请日：2017-10-30
申请人： Universität Basel
发明人： JEKER, LUKAS , BORDOLI SCHWEDE, Lorenza , KORNETE, Mara , SCHWEDE, Torsten , LEPORE, Rosalba , MATTER MARONE, Romina , RECHER, Mike
IPC分类号： A61K35/00
CPC分类号： A61K35/00 , A61K35/12 , C12N2510/0020130101 , C12N5/00 , A61P35/02 , C07K2319/0320130101 , C12N15/102 , C12N2310/2020170501 , C12N9/22 , C07K14/705 , C12N15/902 , A61K39/4644 , C12N5/0636 , A61K2239/3820230501 , A61K39/4611
摘要： The invention relates to a mammalian cell, particularly a human cell, expressing a first isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from a second isoform, for use in a medical treatment of a patient having cells expressing the second isoform form of the surface protein. The invention further relates to an agent selected from 1) a compound comprising, or consisting of, an antibody or antibody-like molecule and 2) an immune effector cell bearing an antibody-like molecule or an immune effector cell bearing a chimeric antigen receptor, for use in a method of treatment of a medical condition, wherein the agent is specifically reactive to either a first or a second isoform of a surface protein, wherein the first isoform is functionally indistinguishable, but immunologically distinguishable from the second isoform, and wherein the agent is administered to ablate a cell bearing the isoform that the agent is reactive to.
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公开(公告)号：EP3535392A1
公开(公告)日：2019-09-11
申请号：EP17797585.1
申请日：2017-10-30
申请人： Universität Basel
发明人： JEKER, Lukas , KORNETE, Mara , BORDOLI SCHWEDE, Lorenza , SCHWEDE, Torsten , LEPORE, Rosalba , MATTER MARONE, Romina , RECHER, Mike
IPC分类号： C12N15/10 , C12N15/90 , C12Q1/68 , A61K35/12 , C07K14/705
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