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公开(公告)号：EP3272768A1
公开(公告)日：2018-01-24
申请号：EP16305952.0
申请日：2016-07-22
申请人： Université Pierre et Marie Curie (Paris 6) , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale)
IPC分类号： C07K14/445 , A61K38/17
CPC分类号： C12N9/52 , A61K38/00 , C07K14/445 , Y02A50/411
摘要： The invention relates to a chimeric peptide construct comprising a cell penetrating peptide linked to a peptide that binds a protein of Plasmodium, especially Protein Phosphatase 1 (PP1). The construct is useful in preventing or treating malaria.
摘要翻译： 本发明涉及一种嵌合肽构建体，其包含与结合疟原虫蛋白质，特别是蛋白质磷酸酶1（PP1）的肽连接的细胞穿透肽。 该构建体可用于预防或治疗疟疾。
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公开(公告)号：EP2414516A1
公开(公告)日：2012-02-08
申请号：EP10712929.8
申请日：2010-03-29
申请人： Université Pierre et Marie Curie - Paris 6 , Centre National de la Recherche Scientifique , Institut National de la Recherche Agronomique , Université Paris Diderot - Paris 7
发明人： REBOLLO GARCIA, Angelita , GARCIA, Alphonse , CAYLA, Xavier , ARROUSS, Issam , BILLOT, Katy , GODET, Angélique
CPC分类号： C12N9/6475 , A61K38/00 , C07K2319/10
摘要： The invention relates to chimeric peptides useful as pro-apoptotic agents, for inhibition of in vitro cell proliferation and for treatment of tumors.
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公开(公告)号：EP3066113A2
公开(公告)日：2016-09-14
申请号：EP14802715.4
申请日：2014-11-04
CPC分类号： C07K14/4703 , A61K38/00 , C07K7/08 , C07K2319/10 , C07K2319/23
摘要： The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a cell-penetrating peptide. These peptides which have a cytotoxic activity are useful, in particular for the treatment of hyperproliferative disorders such as cancer.
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公开(公告)号：EP3016972A2
公开(公告)日：2016-05-11
申请号：EP14735571.3
申请日：2014-07-03
CPC分类号： C07K14/4747 , A61K38/00 , C07K2319/10
摘要： The invention relates to pro-apoptotic peptides, useful in cancer treatment, and to chimeric peptides comprising a cell penetrating peptide linked to a pro-apoptotic peptide, wherein the pro-apoptotic peptide binds Ras or Raf proteins.
摘要翻译： 本发明涉及可用于癌症治疗的促凋亡肽，以及包含与促凋亡肽连接的细胞穿透肽的嵌合肽，其中促凋亡肽结合Ras或Raf蛋白。
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公开(公告)号：EP2797617A1
公开(公告)日：2014-11-05
申请号：EP12816305.2
申请日：2012-12-27
CPC分类号： A61K38/10 , A61K31/337 , A61K31/513 , A61K31/664 , A61K31/704 , A61K33/24 , A61K38/00 , C07K7/08 , C07K14/4747 , C07K2319/10 , C12N9/6475
摘要： A chimeric peptide construct having a cell penetrating peptide linked to a pro-apoptotic peptide. The construct can be used for treating a tumor in combination with an anti-tumor agent. Also disclosed is a method for treating a tumor with the chimeric peptide construct and a chemotherapeutic agent.
摘要翻译： 具有与促凋亡肽连接的细胞穿透肽的嵌合肽构建体。 该构建体可用于与抗肿瘤剂组合治疗肿瘤。 还公开了用嵌合肽构建体和化学治疗剂治疗肿瘤的方法。
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公开(公告)号：EP3277804A1
公开(公告)日：2018-02-07
申请号：EP16714380.9
申请日：2016-03-31
申请人： Université Pierre et Marie Curie - Paris 6 (UPMC) , Institut National de la Santé et de la Recherche Médicale , Agencia Estalal Consejo Superior de Investigaciones Cientificas , Katholieke Universiteit Leuven
发明人： REBOLLO GARCIA, Angelita , BRAVO SICILIA, Jeronimo , FOMINAYA GUTIERREZ, Jesus Maria , WAELKENS, Etienne , JANSSENS, Veerle
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/4702 , C07K2319/01 , C07K2319/10 , C07K2319/70 , C12Y301/03016
摘要： The invention provide chimeric peptides comprising a chimeric peptide comprising a cell-penetrating peptide linked to a pro-apoptotic peptide, wherein the pro-apoptotic peptide is derived from, or consists of, a portion of PP2A protein that binds a SET protein or is derived from, or consists of, a portion of the SET protein that binds PP2A protein.
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公开(公告)号：EP3080296A1
公开(公告)日：2016-10-19
申请号：EP14825274.5
申请日：2014-12-09
CPC分类号： C12Q1/6886 , A61K38/10 , A61K38/1709 , A61K38/4873 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16 , C12Y304/22
摘要： The invention provides an in vitro method for determining the likelihood for a patient affected with a tumor to respond to a treatment with a pro-apoptotic peptide able to disrupt interaction between caspase 9 and PP2A, which method comprises determining expression level of at least each of VIM, MK167, TCF7L2, NEK2, BIRC5, MCL1, and PLK1 genes, in a biological sample of said patient.
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公开(公告)号：EP2797616A1
公开(公告)日：2014-11-05
申请号：EP12813376.6
申请日：2012-12-27
发明人： REBOLLO GARCIA, Angelita , NEMATI, Fariba , DECAUDIN, Didier , BRAVO SICILIA, Jeronimo , FOMINAYA GUTIERREZ, Jesus Maria
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/4747 , C07K2319/00 , C07K2319/10 , C07K2319/31 , C12N7/00 , C12N9/6472 , C12Y304/22062 , Y02A50/411
摘要： A cell-penetrating peptide is described. Also described is a pro-apoptotic agent including the cell-penetrating peptide and a pro-apoptotic peptide linked thereto. The pro-apoptotic agent is useful for inhibition of in vitro cell proliferation and for treatment of tumors.
摘要翻译： 描述细胞穿透肽。 还描述了包括细胞穿透肽和与其连接的促凋亡肽的促凋亡剂。 促凋亡剂可用于抑制体外细胞增殖和治疗肿瘤。
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