公开(公告)号：EP2566573A1

公开(公告)日：2013-03-13

申请号：EP11723540.8

申请日：2011-04-29

申请人： Université Pierre et Marie Curie - Paris 6

发明人： LORACH, Henri ,  DJILAS, Milan ,  YVERT, Blaise ,  BERGONZO, Philippe ,  LISSORGUES, Gaelle ,  ROUSSEAU, Lionel ,  BENOSMAN, Ryad, Benjamin ,  PICAUD, Serge ,  SAHEL, José ,  IENG, Siohoi

IPC分类号： A61N1/05 ,  A61N1/372

CPC分类号： A61N1/0553 ,  A61N1/025 ,  A61N1/05 ,  A61N1/37205

摘要： The invention relates to an implant which includes, in order to electrically stimulate a nerve structure, in particular the retina, an electrically insulating substrate (1), a network of recesses (2) formed in an upper surface of the substrate, stimulation electrodes (3) arranged at the bottom of the recesses, and an electrically conductive layer forming a floorplan (4) at the upper portion of the recesses. The sizes of the recesses and of the electrodes of the implant are such that the spatial selectivity of the stimulation current applied to the nerve structure are maximised.

公开(公告)号：EP2936578A1

公开(公告)日：2015-10-28

申请号：EP13821829.2

申请日：2013-12-24

申请人： Université Pierre et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： PICAUD, Serge ,  BENDALI, Amel ,  BERGONZO, Philippe ,  FOSTER-FRADOT, Valérie ,  SAHEL, José-Alain

IPC分类号： H01L51/00 ,  A61N1/05 ,  B82Y5/00 ,  C12N5/0793 ,  A61N1/36

CPC分类号： A61N1/0526 ,  A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36036 ,  A61N1/36046 ,  B82Y5/00

摘要： An electrode comprising a biocompatible chemically oxygen terminated or H-terminated carbon-based material, the surface of which is substantially free of any peptide coating and promotes the growth or at least the direct interfacing of adult neurons on said material without substantially promoting the growth and direct interfacing of glial cells on said material, said carbon-based material having an electrical conductivity of at least about 0.01S/cm, in particular 1S/cm, said material being in particular selected from the group consisting of nanocrystalline diamond which is doped by either boron, phosphorus or nitrogen, to become a semiconductor, or graphene, nanotubes, or nanotubes on diamond. Further disclosed is a use of said electrode as well as a process of preparation of said electrode.

摘要翻译： 一种电极，其包含生物相容的化学氧封端或H-封端的碳基材料，其表面基本上不含任何肽包衣，并促进成年神经元在所述材料上的生长或至少直接接合，而不显着地促进生长和 胶体细胞在所述材料上的直接接合，所述碳基材料具有至少约0.01S / cm，特别是1S / cm的电导率，所述材料特别地选自纳米晶体金刚石，其由 硼，磷或氮，成为金刚石上的半导体，或石墨烯，纳米管或纳米管。 还公开了所述电极的用途以及所述电极的制备方法。

公开(公告)号：EP2936578B1

公开(公告)日：2017-11-01

申请号：EP13821829.2

申请日：2013-12-24

申请人： Université Pierre et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique ,  Commissariat à l'Énergie Atomique et aux Énergies Alternatives

发明人： PICAUD, Serge ,  BENDALI, Amel ,  BERGONZO, Philippe ,  FOSTER-FRADOT, Valérie ,  SAHEL, José-Alain

IPC分类号： H01L51/00 ,  A61N1/05 ,  B82Y5/00 ,  C12N5/0793 ,  A61N1/36

CPC分类号： A61N1/0526 ,  A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36007 ,  A61N1/36036 ,  A61N1/36046 ,  B82Y5/00

摘要： An electrode comprising a biocompatible chemically oxygen terminated or H-terminated carbon-based material, the surface of which is substantially free of any peptide coating and promotes the growth or at least the direct interfacing of adult neurons on said material without substantially promoting the growth and direct interfacing of glial cells on said material, said carbon-based material having an electrical conductivity of at least about 0.01S/cm, in particular 1S/cm, said material being in particular selected from the group consisting of nanocrystalline diamond which is doped by either boron, phosphorus or nitrogen, to become a semiconductor, or graphene, nanotubes, or nanotubes on diamond. Further disclosed is a use of said electrode as well as a process of preparation of said electrode.

公开(公告)号：EP2566573B1

公开(公告)日：2015-07-29

申请号：EP11723540.8

申请日：2011-04-29

申请人： Université Pierre et Marie Curie (Paris 6)

发明人： LORACH, Henri ,  DJILAS, Milan ,  YVERT, Blaise ,  BERGONZO, Philippe ,  LISSORGUES, Gaelle ,  ROUSSEAU, Lionel ,  BENOSMAN, Ryad, Benjamin ,  PICAUD, Serge ,  SAHEL, José ,  IENG, Siohoi

IPC分类号： A61N1/02

CPC分类号： A61N1/0553 ,  A61N1/025 ,  A61N1/05 ,  A61N1/37205