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公开(公告)号：EP3286566B1
公开(公告)日：2019-07-03
申请号：EP16717922.5
申请日：2016-04-21
申请人： Université d'Aix-Marseille , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Montpellier , Centre Hospitalier Universitaire de Nîmes , Assistance Publique Hôpitaux de Marseille
发明人： BARDIN, Nathalie , BLOT-CHABAUD, Marcel , BOUVIER, Sylvie , LACROIX, Odile , DIGNAT-GEORGE, Françoise , GRIS, Jean-Christophe, Raymond
IPC分类号： G01N33/68
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2.发明公开
公开(公告)号：EP3629024A1
公开(公告)日：2020-04-01
申请号：EP18306253.8
申请日：2018-09-26
申请人： Assistance Publique - Hôpitaux de Marseille , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université d'Aix Marseille , Queen Mary University of London , Sorbonne Université
发明人： LEROYER, Aurélie , BLOT-CHABAUD, Marcel , CHADJICHRISTOS, Christos , BARDIN, Nathalie , DIGNAT-GEORGE, Françoise , BERTAUD, Alexandrine , GUILLET, Benjamin , THIEMERMANN, Christoph , HACHE, Guillaume
摘要： The present invention relates to the field of medicine and in particular to the diagnostic and treatment of fibrosis. More particularly, the invention relates to CD146 and uses thereof as a biomarker in the diagnosis of fibrosis and as a therapeutic target in the treatment of fibrosis. The invention also relates to compositions and methods of detecting predisposition to, of diagnosing, prognosing and/or monitoring fibrosis in a subject. It further relates to CD146 inhibitors, and to compositions comprising a CD146 inhibitor, for use in prevention or treatment of fibrosis in a subject, as well as to compositions, kits and uses thereof in a diagnostic or therapeutic context.
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3.发明公开
公开(公告)号：EP3655777A1
公开(公告)日：2020-05-27
申请号：EP18743520.1
申请日：2018-07-20
申请人： Universite d'Aix-Marseille , Université Côte d'Azur , Assistance Publique Hôpitaux de Marseille , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人： BLOT-CHABAUD, Marcel , PAGES, Gilles , DUFIES, Maeva , BARDIN, Nathalie , DIGNAT-GEORGE, Françoise
IPC分类号： G01N33/574
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公开(公告)号：EP3692074A1
公开(公告)日：2020-08-12
申请号：EP18785898.0
申请日：2018-10-05
申请人： Universite d'Aix-Marseille , INSERM (Institut National de la Santé et de la Recherche Médicale) , Assistance Publique Hôpitaux de Marseille
发明人： BLOT-CHABAUD, Marcel , GUILLET, Benjamin , NOLLET, Marie , STALIN, Jimmy , BARDIN, Nathalie , DIGNAT-GEORGE, Françoise
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , A61K51/10
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公开(公告)号：EP2391712B1
公开(公告)日：2016-03-30
申请号：EP10702657.7
申请日：2010-01-29
申请人： Université d'Aix-Marseille , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人： BLOT-CHABAUD, Marcel , HARHOURI, Karim , BARDIN, Nathalie , GUILLET, Benjamin , DIGNAT-GEORGE, Françoise
IPC分类号： C12N5/071
CPC分类号： C07K16/3092 , A61K38/00 , C07K14/70503
摘要： The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both nature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.
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6.发明授权
公开(公告)号：EP2150623B8
公开(公告)日：2012-12-19
申请号：EP08805655.1
申请日：2008-06-06
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7.发明公开
公开(公告)号：EP3857233A1
公开(公告)日：2021-08-04
申请号：EP19773102.9
申请日：2019-09-26
申请人： Assistance Publique Hôpitaux de Marseille , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université d'Aix Marseille , Queen Mary University of London , Sorbonne Université
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公开(公告)号：EP2391712A1
公开(公告)日：2011-12-07
申请号：EP10702657.7
申请日：2010-01-29
申请人： Universite De La Mediterranee , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人： BLOT-CHABAUD, Marcel , HARHOURI, Karim , BARDIN, Nathalie , GUILLET, Benjamin , DIGNAT-GEORGE, Françoise
IPC分类号： C12N5/071
CPC分类号： C07K16/3092 , A61K38/00 , C07K14/70503
摘要： The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both nature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.
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公开(公告)号：EP4168054A1
公开(公告)日：2023-04-26
申请号：EP21732341.9
申请日：2021-06-18
申请人： Universite d'Aix Marseille , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Assistance Publique Hôpitaux de Marseille
发明人： GUILLET, Benjamin , BOUHLEL, Ahlem , MOYON, Anaïs , LOUIS, Béatrice, Marie, Florence , DIGNAT-GEORGE, Françoise , BALASSE, Laure , GARRIGUE, Philippe , FERNANDEZ, Samantha
IPC分类号： A61K51/08
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10.发明公开
公开(公告)号：EP2150623A2
公开(公告)日：2010-02-10
申请号：EP08805655.1
申请日：2008-06-06
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique Hôpitaux de Marseille , Université de la Méditerranée , Universite De Caen Basse-Normandie
摘要： The invention relates to a method for measuring the plasmine activity of microparticles, in particular circulating microparticles, in a sample of a biological fluid, particularly a biological fluid in a flow situation, wherein said method can be used as a diagnosis method or a method for following a treatment.
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