公开(公告)号：EP3946616A1

公开(公告)日：2022-02-09

申请号：EP20712966.9

申请日：2020-03-23

申请人： Université de Bretagne Occidentale (U.B.O.) ,  Centre Hospitalier Régional et Universitaire de Brest ,  Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  A61K39/395

公开(公告)号：EP3946615A1

公开(公告)日：2022-02-09

申请号：EP20711951.2

申请日：2020-03-23

申请人： Université de Bretagne Occidentale (U.B.O.) ,  Centre Hospitalier Régional et Universitaire de Brest ,  Institut National de la Santé et de la Recherche Médicale (INSERM)

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28

公开(公告)号：EP3262414B1

公开(公告)日：2019-11-20

申请号：EP16706847.7

申请日：2016-02-26

申请人： Université de Bretagne Occidentale (U.B.O.) ,  Inserm ,  Centre Hospitalier Régional et Universitaire de Brest

发明人： RENAUDINEAU, Yves ,  MIGNEN, Olivier ,  DEBANT, Marjolaine ,  LE DANTEC, Christelle ,  PERS, Jacques Olivier

IPC分类号： G01N33/564 ,  G01N33/574 ,  G01N33/68

公开(公告)号：EP3262414A1

公开(公告)日：2018-01-03

申请号：EP16706847.7

申请日：2016-02-26

申请人： Université de Bretagne Occidentale (U.B.O.) ,  Inserm ,  Centre Hospitalier Régional et Universitaire de Brest

发明人： RENAUDINEAU, Yves ,  MIGNEN, Olivier ,  DEBANT, Marjolaine ,  LE DANTEC, Christelle ,  PERS, Jacques Olivier

IPC分类号： G01N33/564 ,  G01N33/574 ,  G01N33/68

摘要： The present invention relates to a process for the diagnosis of systemic lupus erythematosus (SLE) and/or of chronic lymphoid leukaemia (CLL) of a subject who may be suffering therefrom, comprising the in vitro detection of the expression of the fraction of the STIM1 protein located at the cell plasma membrane in a biological sample from the subject. It also relates to a process for predicting the progression and/or monitoring the progression of CLL and/or of SLE, comprising the in vitro detection of the expression of the fraction of the STIM1 protein located at the cell plasma membrane.

公开(公告)号：EP3714943A1

公开(公告)日：2020-09-30

申请号：EP19305448.3

申请日：2019-04-05

申请人： Université De Bretagne Occidentale - UBO ,  Centre Hospitalier Régional et Universitaire de Brest ,  Inserm

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28

摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201 of the human STIM1 amino acid sequence SEQ ID NO: 1.
The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid.
The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 58 and 201 for developing modulators of the STIM1 amino acid sequence SEQ ID NO: 1.

公开(公告)号：EP3714942A1

公开(公告)日：2020-09-30

申请号：EP19305447.5

申请日：2019-04-05

申请人： Université De Bretagne Occidentale - UBO ,  Centre Hospitalier Régional et Universitaire de Brest ,  Inserm

发明人： MIGNEN, Olivier ,  RENAUDINEAU, Yves ,  DEBANT, Marjolaine ,  HEMON, Patrice

IPC分类号： A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  A61K39/395

摘要： The present invention relates to a compound that specifically binds to the region between amino acid residues 58 and 201, preferably 97 and 127 of the human STIM1 amino acid sequence SEQ ID NO: 1.
The present invention also relates to a composition comprising a therapeutically effective amount of the compound, a host cell that produces an isolated antibody, an isolated nucleic acid sequence encoding the isolated antibody and an expression vector comprising the nucleic acid.
The present invention additionally relates to a method of producing the isolated antibody, to the isolated antibody for its use as a drug, especially for its use in treating a condition or a disorder in which the STIM1 protein localized to the plasma membrane of the cells is overexpressed, and to an isolated protein fragment consisting of the region between amino acid residues 97 and 127 for developing modulators of the STIM1 amino acid sequence SEQ ID NO: 1.