公开(公告)号：EP4098252A1

公开(公告)日：2022-12-07

申请号：EP21386032.3

申请日：2021-06-02

申请人： Université de Liège ,  Fundacio Institut de Bioenginyeria de Catalunya ,  Barcelona Institute For Global Health ,  Foundation For Research And Technology Hellas

发明人： Grandfils, Christian ,  Sevrin, Chantal ,  Fernàndez Busquets, Xavier ,  Siden-Kiamos, Inga ,  Vontas, John

IPC分类号： A61K9/16 ,  A61K31/121 ,  A61K31/122 ,  A61K31/167 ,  A61P43/00

摘要： The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I):

wherein R 1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH; a complex for use in a method of medical treatment; a pharmaceutical composition; and a method of preparing a complex according to the invention which method comprises the steps of:
(a) dissolving the hydrophobic active agent and the ionic polymer in one or more non-aqueous solvents to form the complex wherein the one or more non-aqueous solvents are miscible with water; and
(b) progressively replacing the one or more non-aqueous solvents with water.

公开(公告)号：EP2842548A1

公开(公告)日：2015-03-04

申请号：EP13182277.7

申请日：2013-08-29

申请人： Université de Liège

发明人： Grandfils, Christian ,  Flebus, Luca ,  Sevrin, Chantal

IPC分类号： A61K9/19 ,  A61K31/727 ,  A61K31/78 ,  A61K31/785 ,  A61P39/02

CPC分类号： A61K31/785 ,  A61K9/0019 ,  A61K31/727 ,  A61K31/78 ,  A61K47/34 ,  B01J41/14 ,  C08F120/34 ,  A61K2300/00

摘要： A polymer of formula (I):

where X 1 and X 2 respectively represent the alpha and omega end groups of the polymer;
R 1 represents a hydrogen atom or a straight or branched chain alkyl group;
R 2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at physiological pH; and
n represents the number of repetitive units of the polymer;
or a copolymer thereof;
for use as a medicament and for treatment of a heparin overdose wherein the polymer of formula (I) has been found to have a selectivity and affinity for heparin.

摘要翻译： 式（I）的聚合物：其中X 1和X 2分别表示聚合物的α和ω端基; R 1表示氢原子或直链或支链烷基; R 2表示在生理pH下可以具有正电荷的基团取代的直链或支链烷基; n表示聚合物的重复单元数; 或其共聚物; 用作药物和用于治疗肝素过量，其中已经发现式（I）的聚合物对肝素具有选择性和亲和力。