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1.发明公开4-FLUOROPHENYL-DERIVATIVES OF 1-{[1,5 -BIS (4-CHLOROPHENYL) -2-METHYL-1H-PYRROL-3-YL]METHYL} -4- METHYLPIPERAZINE, SYNTHESIS PROCESS AND USES THEREOF 审中-公开{[1,5-双（4-氯苯基）-2-甲基-1H-吡咯-3-基]甲基} -4-甲基哌嗪，合成方法和应用 - 的1 4- FLUORPHENYLDERIVATE
公开(公告)号：EP1866283A2
公开(公告)日：2007-12-19
申请号：EP06711446.2
申请日：2006-03-03
发明人： BIAVA, Mariangela , MANETTI, Fabrizio , DEIDDA, Delia , POMPEI, Raffaello , BOTTA, Maurizio , PORRETTA, Giulio, Cesare
IPC分类号： C07D207/32 , A61K31/402 , A61P31/06
CPC分类号： C07D207/335
摘要： The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4- chlorophenyl)-2-methyl-lH-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
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公开(公告)号：EP3765454A1
公开(公告)日：2021-01-20
申请号：EP19711363.2
申请日：2019-03-18
发明人： BOTTA, Maurizio , CANDUCCI, Filippo , CAGNO, Valeria , LEMBO, David , TINTORI, Cristina , BRAI, Annalaura , PALOMBI, Nastasja
IPC分类号： C07D403/06 , C07D417/06 , A61P31/12 , A61K31/427 , A61K31/515
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3.发明公开
公开(公告)号：EP1948619A2
公开(公告)日：2008-07-30
申请号：EP06810026.2
申请日：2006-10-13
发明人： BOTTA, Maurizio , CORELLI, Federico , PETRICCI, Elena , RADI, Marco , MAGA, Giovanni , ESTE'A., José , MAI, Antonello
IPC分类号： C07D239/46 , C07D239/56 , A61K31/513 , A61P31/18
CPC分类号： C07D239/47 , C07D239/56
摘要： The invention relates to 6-vinyl pyrimidine pyrimidinone derivatives and the use thereof as medicaments in particular for the treatment of HTV infections, the use thereof for preparing pharmaceutical compositions and methods for the preparation thereof.
摘要翻译： 本发明涉及6-乙烯基嘧啶嘧啶酮衍生物及其作为药物特别是用于治疗HIV感染的药物的用途，其用于制备药物组合物的用途及其制备方法。
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4.发明授权PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO 有权分枝杆菌，其合成及其中间体的吡咯作为抑制剂
公开(公告)号：EP2195289B1
公开(公告)日：2013-06-19
申请号：EP08807801.9
申请日：2008-09-25
发明人： BIAVA, Mariangela , PORRETTA, Giulio Cesare , POMPEI, Raffaello , BOTTA, Maurizio , MANETTI, Fabrizio , DE LOGU, Alessandro
IPC分类号： C07D207/33 , A61K31/402 , A61P31/06 , C07D417/06
CPC分类号： C07D207/335
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公开(公告)号：EP2536405A1
公开(公告)日：2012-12-26
申请号：EP11707916.0
申请日：2011-02-16
发明人： BOTTA, Maurizio , CORRADI, Valentina , FALCHI, Federico , MANCINI, Manuela , SANTUCCI, Maria Alessandra
IPC分类号： A61K31/196 , A61K31/4035 , G01N33/50 , A61P35/02
CPC分类号： A61K31/4152 , A61K31/196 , A61K31/4035 , C12Q1/485 , G01N33/573 , G01N33/57426
摘要： The present invention refers to compounds with inhibitory activity against 14-3-3 proteins and their use in the treatment of tumor, in particular chronic myeloid leukemia. The invention also provides methods for the identification of14-3-3 protein inhibitors.
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6.发明公开NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-D] PYRIMIDINE AND PYRROLO [2,3-D] PYRIMIDINE AND USES THEREOF 有权吡唑并[3,4-D]嘧啶和吡咯并[2,3-d]嘧啶的新4-取代的衍生物及其用途
公开(公告)号：EP2201013A2
公开(公告)日：2010-06-30
申请号：EP08807624.5
申请日：2008-09-12
发明人： SCHENONE, Silvia , BONDAVALLI, Francesco , BRUNO, Olga , BOTTA, Maurizio , MANETTI, Fabrizio , RADI, Marco , SANTUCCI, Alessandra , MAGA, Giovanni , BOLOGNA, Mauro , ANGELUCCI, Adriano , SANTUCCI, Annalisa , SPREAFICO, Adriano , CARRARO, Fabio , BORLAK, Jurgen
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4- d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseasesand tumours.
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7.发明公开PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO 有权分枝杆菌，其合成及其中间体的吡咯作为抑制剂
公开(公告)号：EP2195289A2
公开(公告)日：2010-06-16
申请号：EP08807801.9
申请日：2008-09-25
发明人： BIAVA, Mariangela , PORRETTA, Giulio Cesare , POMPEI, Raffaello , BOTTA, Maurizio , MANETTI, Fabrizio , DE LOGU, Alessandro
IPC分类号： C07D207/33 , A61K31/402 , A61P31/06 , C07D417/06
CPC分类号： C07D207/335
摘要： The present invention relates to a compound having the general formula (3): synthesis, intermediates and uses thereof.
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8.发明授权NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-D] PYRIMIDINE AND PYRROLO [2,3-D] PYRIMIDINE AND USES THEREOF 有权吡唑并[3,4-D]嘧啶和吡咯并[2,3-d]嘧啶的新4-取代的衍生物及其用途
公开(公告)号：EP2201013B1
公开(公告)日：2014-11-19
申请号：EP08807624.5
申请日：2008-09-12
发明人： SCHENONE, Silvia , BONDAVALLI, Francesco , BRUNO, Olga , BOTTA, Maurizio , MANETTI, Fabrizio , RADI, Marco , SANTUCCI, Alessandra , MAGA, Giovanni , BOLOGNA, Mauro , ANGELUCCI, Adriano , SANTUCCI, Annalisa , SPREAFICO, Adriano , CARRARO, Fabio , BORLAK, Jurgen
IPC分类号： C07D487/04
CPC分类号： C07D487/04
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公开(公告)号：EP2274290B1
公开(公告)日：2012-09-26
申请号：EP09719584.6
申请日：2009-03-12
发明人： BOTTA, Maurizio , RAFFI, Francesco , VISCA, Paolo
IPC分类号： C07D255/02 , C07D259/00 , A61K31/395 , A61P31/10
CPC分类号： C07D255/02 , C07C279/12 , C07C2601/02 , C07D259/00
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10.发明公开LINEAR AND CYCLIC GUANIDINE DERIVATIVES, METHOD OF PREPARATION AND USES THEREOF 有权环境署负责人安德森森（DENEN ANWENDUNGEN）发布
公开(公告)号：EP2274290A2
公开(公告)日：2011-01-19
申请号：EP09719584.6
申请日：2009-03-12
发明人： BOTTA, Maurizio , RAFFI, Francesco , VISCA, Paolo
IPC分类号： C07D255/02 , C07D259/00 , A61K31/395 , A61P31/10
CPC分类号： C07D255/02 , C07C279/12 , C07C2601/02 , C07D259/00
摘要： The present invention relates to linear and cyclic guanidine derivatives, method of preparation and uses thereof, pharmaceutical compositions to be used as antifungal agents, in particular against Candida species.
摘要翻译： 本发明涉及线性和环状胍衍生物，其制备方法及其用途，用作抗真菌剂，特别是针对念珠菌种的药物组合物。
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