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1.发明公开THREE-DIMENSIONAL MAMMALIAN OVARIAN FOLLICULAR CELL AND OVARIAN FOLLICLE CULTURE SYSTEMS IN A BIOCOMPATIBLE MATRIX 有权三种哺乳动物卵巢FOLLIKULARZELL-和卵巢FOLLIKULARZELL培养系统处于生物相容性基质
公开(公告)号：EP1706103A2
公开(公告)日：2006-10-04
申请号：EP04803101.7
申请日：2004-11-02
申请人： Universita' Degli Studi di Milano , Conte, Ubaldo , Torre, Maria Luisa , Universita' degli Studi di Bologna
发明人： VIGO, Daniele Università Degli Studi di Milano , RUSSO, Vincenzo Università Degli Studi di Milano , FAUSTINI, Massimo Univ. Degli Studi di Milano , STACCHEZZINI, Simona Univ. Degli Studi di Milano , CONTE, Ubaldo Università Degli Studi di Pavia , TORRE, Maria Luisa Univ. Degli Studi di Pavia , ACCORSI, Pier Attilio Univ. Degli Studi di Bologna , GALEATI, Giovanna Univ. Degli Studi di Bologna , SPINACI, Marcella Univ. Degli Studi di Bologna
CPC分类号： C12N5/0609 , A61K9/5036 , A61K35/48 , C12N5/0012 , C12N2502/243 , C12N2533/74
摘要： A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro, and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules are constituted by: a nucleus containing stem cells, ovarian follicular cells, gametes ovarian follicles or mammalian embryos and/or a biocompatible and/or biodegradable polymer; a semi-permeable membrane constituted by a divalent or trivalent metal ion salt of alginic acid, optionally cross-linked on the inner and/or outer surface and/or on both surfaces, optionally vehicularising a second or more cellular species. The cells and follicles prepared and cultivated using this methodology are used for the in vitro and/or in vivo production of peptides, proteins, antibodies, hormones and hormone precursors, metabolites and catabolites typical of these cellular structures, plasma membranes, nuclear membranes, cytoplasmic organelles, somatic cell nuclei or gametes and embryos.
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2.发明授权THREE-DIMENSIONAL MAMMALIAN OVARIAN FOLLICULAR CELL AND OVARIAN FOLLICLE CULTURE SYSTEMS IN A BIOCOMPATIBLE MATRIX 有权三种哺乳动物卵巢FOLLIKULARZELL-和卵巢FOLLIKULARZELL培养系统处于生物相容性基质
公开(公告)号：EP1706103B1
公开(公告)日：2013-07-10
申请号：EP04803101.7
申请日：2004-11-02
申请人： Universita' degli Studi di Milano , Conte, Ubaldo , Torre, Maria Luisa , Universita' degli Studi di Bologna
发明人： VIGO, Daniele Università Degli Studi di Milano , RUSSO, Vincenzo Università Degli Studi di Milano , FAUSTINI, Massimo Univ. Degli Studi di Milano , STACCHEZZINI, Simona Univ. Degli Studi di Milano , CONTE, Ubaldo Università Degli Studi di Pavia , TORRE, Maria Luisa Univ. Degli Studi di Pavia , ACCORSI, Pier Attilio Univ. Degli Studi di Bologna , GALEATI, Giovanna Univ. Degli Studi di Bologna , SPINACI, Marcella Univ. Degli Studi di Bologna
CPC分类号： C12N5/0609 , A61K9/5036 , A61K35/48 , C12N5/0012 , C12N2502/243 , C12N2533/74
摘要： A process for encapsulating and immobilising mammalian stem cells, ovarian follicular cells, gametes, ovarian follicles or mammalian embryos which are able to auto-organise into three-dimensional structures in vitro, and express biological functions in a manner similar to that which is observed in the organism in vivo is described. The capsules are constituted by: a nucleus containing stem cells, ovarian follicular cells, gametes ovarian follicles or mammalian embryos and/or a biocompatible and/or biodegradable polymer; a semi-permeable membrane constituted by a divalent or trivalent metal ion salt of alginic acid, optionally cross-linked on the inner and/or outer surface and/or on both surfaces, optionally vehicularising a second or more cellular species. The cells and follicles prepared and cultivated using this methodology are used for the in vitro and/or in vivo production of peptides, proteins, antibodies, hormones and hormone precursors, metabolites and catabolites typical of these cellular structures, plasma membranes, nuclear membranes, cytoplasmic organelles, somatic cell nuclei or gametes and embryos.
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