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1.发明公开THURICIN CD, AN ANTIMICROBIAL FOR SPECIFICALLY TARGETING CLOSTRIDIUM DIFFICILE 审中-公开THURICIN CD，EIN SPEZIFISCH AUF CLOSTRIDIUM DIFFICILE ZIELENDES ANTIMIKROBIELLES MITTEL
公开(公告)号：EP2227484A1
公开(公告)日：2010-09-15
申请号：EP08855713.7
申请日：2008-11-28
申请人： TEAGASC, The Agriculture and Food Development Authority , University College Cork-National University of Ireland, Cork
发明人： HILL, Colin , REA, Mary , ROSS, Paul
CPC分类号： C07K14/32 , A61K38/00 , A61K2035/11 , C12N1/06 , C12R1/075 , Y10S435/832
摘要： The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.
摘要翻译： 本发明涉及一种新的细菌素，可以产生它的微生物菌株以及细菌素和菌株的用途。 细菌素在其他生物体内对艰难梭菌和单核细胞增生利斯特氏菌有效。
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2.发明公开ANTIMICROBIAL PEPTIDE PRODUCED BY INTESTINAL LACTOBACILLUS SALIVARIUS 审中-公开AUS INTESTINALEM LACTOBACILLUS SALIVARIUS HERGESTELLTES ANTIMIKROBIELLES PEPTID
公开(公告)号：EP2736924A1
公开(公告)日：2014-06-04
申请号：EP12748662.9
申请日：2012-07-27
申请人： University College Cork, National University Of Ireland , Agriculture and Food Development Authority (TEAGASC)
发明人： ROSS, Paul , O'SHEA, Eileen , HILL, Colin
IPC分类号： C07K14/335
CPC分类号： C07K14/335 , A23L33/18 , A23Y2220/79 , A61K35/00 , A61K38/00 , C12R1/225
摘要： An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide having potent antibacterial activity against Lactobacillus delbrueckii subspecies bulgaricus, Listeria and Staphylococcus aureus.
摘要翻译： 描述了对单核细胞增生利斯特氏菌和金黄色葡萄球菌具有有效抗菌活性的抗微生物肽。 还描述了以保藏号NCIMB 41840保藏在National Collection of Industrial and Marine Bacteria的分离的唾液乳杆菌DPC6502菌株及其变体，其中分离的细菌及其变体表达对德氏乳杆菌具有强抗菌活性的抗微生物肽 亚种保加利亚，李斯特菌和金黄色葡萄球菌。
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公开(公告)号：EP3338785A1
公开(公告)日：2018-06-27
申请号：EP16205996.8
申请日：2016-12-21
申请人： Agriculture and Food Development Authority (TEAGASC) , University College Cork - National University of Ireland, Cork
IPC分类号： A61K35/747 , G01N33/48 , C12N1/20 , A61P31/04
CPC分类号： A61K35/747 , C12N1/20 , C12Q1/045 , G01N2333/33 , G01N2333/335
摘要： Clostridium difficile is one of the most common causes of health-care acquired diarrhoea, resulting in a spectrum of disease from mild diarrhoea to life-threatening illness. Particular human Lactobacillus strains, including Lactobacillus gasseri APC678, are described as useful therapeutic agents to target C. difficile colonisation or infection.
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公开(公告)号：EP1089754A2
公开(公告)日：2001-04-11
申请号：EP99928186.8
申请日：1999-06-22
申请人： TEAGASC, THE AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY , University College Cork-National University of Ireland, Cork
发明人： ROSS, Reynolds Paul , HILL, Colin
IPC分类号： A61K38/16
CPC分类号： A61K38/164 , A61K9/0041 , A61K2300/00
摘要： An antimicrobial which is effective against a range of Gram positive organisms is described. The antimicrobial is the bacteriocin lacticin 3147, which is shown to be effective both in vivo and in vitro against a range of Gram positive organisms.
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公开(公告)号：EP3934676A1
公开(公告)日：2022-01-12
申请号：EP20706770.3
申请日：2020-03-04
申请人： University College Cork-National University of Ireland Cork , TEAGASC, The Agriculture and Food Development Authority
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6.发明公开BILE SALT HYDROLASE BSH1 FOR REGULATING WEIGHT GAIN, SERUM CHOLESTEROL LEVELS, AND LIVER TRIGLYCERIDES IN A MAMMAL; BACTERIA STRAINS EXPRESSING BSH1 VARIANTS 审中-公开GALLENSALZHYDROLASE BSH1用于控制体重增加，血清胆固醇水平及与哺乳动物LEBERTRIGLYCERIDE，BSH1变体表达株细菌
公开(公告)号：EP3007723A1
公开(公告)日：2016-04-20
申请号：EP14736652.0
申请日：2014-06-12
发明人： JOYCE, Susan , GAHAN, Cormac , HILL, Colin
CPC分类号： A61K38/50 , A23K10/18 , A23V2002/00 , A61K8/66 , A61K8/99 , A61K9/0053 , A61K35/747 , A61K2035/115 , A61P3/04 , A61Q19/06 , C12N9/80 , C12Y305/01024
摘要： A non-therapeutic method of reducing weight gain, serum cholesterol levels, or liver triglyceride levels, in a non-obese mammal, comprises the step of administering to the gut of a mammal an effective amount of a bacteria expressing a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof; a BSH1 enzyme of SEQUENCE ID NO: 1, or a functional variant thereof for use as a medicament; isolated bacterial strains expressing functional variants of BSH1.
摘要翻译： 降低在非肥胖哺乳动物的体重增加，血清胆固醇水平，或肝甘油三酯水平的非治疗方法，包括给予有效量的细菌的哺乳动物的阱表达SEQUENCE ID的BSH1酶的步骤 NO：1，或其功能性变体; SEQUENCE ID NO的BSH1酶：1，或为用作药物或其功能性变体; 分离的细菌菌株表达BSH1的功能性变体。
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公开(公告)号：EP2280990A1
公开(公告)日：2011-02-09
申请号：EP09742163.0
申请日：2009-05-08
发明人： COTTER, Paul , HILL, Colin
IPC分类号： C07K14/195
CPC分类号： C07K14/315 , A23C19/11 , A23L3/34635 , A61K38/164
摘要： The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.
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公开(公告)号：EP3822285A1
公开(公告)日：2021-05-19
申请号：EP19208735.1
申请日：2019-11-12
申请人： University College Cork-National University of Ireland, Cork , TEAGASC, The Agriculture and Food Development Authority
发明人： COTTER, Paul , SHEEHAN, Diarmuid , BHAGYA JONNALA, Rekha , FIELD, Des , HILL, Colin , ROSS, Paul
IPC分类号： C07K14/315 , A23L3/3526 , A61K38/16
摘要： The invention relates to a variant nisin peptide, wherein the variant nisin peptide is a modified variant of wild-type nisin, wherein the modification comprises or consists of an amino acid residue modification selected from: i) M17Q or M17A; ii) T2L; and iii) one set of modified hinge residues selected from a) N20H and M21T, b) N20V, M21G, and K22A, c) N20V, M21G, and K22V or d) N20V, M21G, and K22T; or v) combinations of modifications i), ii), and iii), and related medical uses and products comprising such nisin peptides.
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公开(公告)号：EP3705131A1
公开(公告)日：2020-09-09
申请号：EP19160469.3
申请日：2019-03-04
申请人： University College Cork-National University of Ireland, Cork , Agriculture and Food Development Authority (TEAGASC)
发明人： ROSS, Reynolds Paul , STANTON, Catherine , HILL, Colin , RYAN, Anothony , O'SULLIVAN, Julie , WATKINS, Claire
摘要： An isolated lantibiotic is provided comprising amino acid sequence SEQ. ID No. 2 and at least one of amino acid sequences SEQ. ID No. 4 and SEQ. ID. No 6. Also provided is use of the lantibiotic in the treatment or prevention of infection by Group B Streptococcus or Corynebacterium xerosis. The invention further relates to isolated S. hominis strains and use of same in producing the lantibiotic. A vector is provided comprising nucleotides sequences for producing the lantibiotic.
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公开(公告)号：EP2280990B1
公开(公告)日：2020-04-08
申请号：EP09742163.0
申请日：2009-05-08
发明人： COTTER, Paul , HILL, Colin
IPC分类号： C07K14/195
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