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公开(公告)号：EP4132918A1
公开(公告)日：2023-02-15
申请号：EP21717085.1
申请日：2021-04-08
IPC分类号： C07D401/04 , C07D403/04 , A61P33/06 , A61K31/4725 , A61K31/506
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公开(公告)号：EP3892332A1
公开(公告)日：2021-10-13
申请号：EP20169099.7
申请日：2020-04-09
IPC分类号： A61P33/06 , C07D401/04 , C07D403/04 , A61K31/4725 , A61K31/506
摘要： The present invention is related to new derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to dihydroisoquinoline derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.
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3.发明公开SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES 有权替代物2-烷基-1-氧代-N-苯基-3-异辛基-1,2,3,4-四氢代环辛烯-4-羧酰胺F抗原抗体
公开(公告)号：EP2748147A1
公开(公告)日：2014-07-02
申请号：EP12772470.6
申请日：2012-08-24
申请人： St. Jude Children's Research Hospital , MMV Medicines for Malaria Venture , Rutgers, The State University Of New Jersey
发明人： GUY, Rodney Kiplin , ZHU, Fangyi , GUIGUEMDE, Wendyam Armand , FLOYD, David , KNAPP, Spencer , STEIN, Philip , CASTRO, Steve
IPC分类号： C07D217/26 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/47 , A61P33/06
CPC分类号： C07D401/04 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D409/04 , C07D417/04
摘要： In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及新的取代的2-烷基-1-氧代-N-苯基-3-杂芳基-1,2,3,4-四氢异喹啉-4-甲酰胺; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及治疗和/或预防疟疾的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：EP2483274B1
公开(公告)日：2014-10-29
申请号：EP10821105.3
申请日：2010-09-28
申请人： Board of Regents, The University of Texas System , Monash University , MMV Medicines for Malaria Venture , University of Washington , Glaxosmithkline Investigacion y Desarrollo, S.L.
发明人： RATHOD, Pradipsinh, K. , FLOYD, David , BURROWS, Jeremy , MARWAHA, Alka , GUJJAR, Ramesh , COTERON-LOPEZ, Jose , PHILLIPS, Margaret , CHARMAN, Susan, A. , MATTHEWS, David
IPC分类号： C07D487/04 , A61K31/519 , A61P33/06
CPC分类号： C07D487/04
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5.发明授权SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES 有权用于抗疟疾治疗的取代的2-烷基-1-氧代-N-苯基-3-杂芳基-1,2,3,4-四氢异喹啉-4-甲酰胺
公开(公告)号：EP2748147B1
公开(公告)日：2017-08-02
申请号：EP12772470.6
申请日：2012-08-24
申请人： St. Jude Children's Research Hospital , MMV Medicines for Malaria Venture , Rutgers, The State University Of New Jersey
发明人： GUY, Rodney Kiplin , ZHU, Fangyi , GUIGUEMDE, Wendyam Armand , FLOYD, David , KNAPP, Spencer , STEIN, Philip , CASTRO, Steve
IPC分类号： C07D409/04 , A61K31/4725 , A61K31/506 , C07D417/04 , C07D401/04
CPC分类号： C07D401/04 , A61K31/4725 , A61K31/506 , A61K45/06 , C07D409/04 , C07D417/04
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