公开(公告)号：EP4325520A3

公开(公告)日：2024-05-15

申请号：EP24150806.8

申请日：2010-05-28

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G16H20/17 ,  G16H50/20 ,  G16H50/50 ,  G16H20/30 ,  G16H20/60

CPC分类号： G16H50/50 ,  G16H50/20 ,  G16H20/17 ,  G16H20/60 ,  G16H20/30

摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.

公开(公告)号：EP4231307A1

公开(公告)日：2023-08-23

申请号：EP23175347.6

申请日：2010-05-28

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G16H20/17 ,  G16H50/20 ,  G16H50/50 ,  G16H20/30 ,  G16H20/60

摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.

公开(公告)号：EP4325520A2

公开(公告)日：2024-02-21

申请号：EP24150806.8

申请日：2010-05-28

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G16H50/50

摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.

公开(公告)号：EP4303884A2

公开(公告)日：2024-01-10

申请号：EP23192708.8

申请日：2017-01-30

申请人： University of Virginia Patent Foundation d/b/a University of Virginia Licensing & Ventures Group

发明人： PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G16H40/63

摘要： A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

公开(公告)号：EP3017389A2

公开(公告)日：2016-05-11

申请号：EP14819899.7

申请日：2014-07-03

申请人： University of Virginia Patent Foundation

发明人： BRETON, Marc D. ,  KOVATCHEV, Boris P. ,  DALLA MAN, Chiara ,  COBELLI, Claudio ,  MICHELETTO, Francesco

IPC分类号： G06F19/18

CPC分类号： G06F19/702 ,  G06F19/00 ,  G16H50/50

摘要： A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.

公开(公告)号：EP4303884A3

公开(公告)日：2024-04-03

申请号：EP23192708.8

申请日：2017-01-30

申请人： University of Virginia Patent Foundation d/b/a University of Virginia Licensing & Ventures Group

发明人： PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G16H10/60 ,  G16H50/50 ,  G16H50/70

摘要： A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

公开(公告)号：EP4196004A1

公开(公告)日：2023-06-21

申请号：EP21856786.5

申请日：2021-08-13

申请人： University of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  BRETON, Marc D. ,  WANG, Ke ,  COLMEGNA, Patricio

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61M1/00 ,  A61M5/172

公开(公告)号：EP3996590A1

公开(公告)日：2022-05-18

申请号：EP20836450.5

申请日：2020-07-10

申请人： University Of Virginia Patent Foundation

发明人： BRETON, Marc D. ,  HUGHES, Jonathan ,  ANDERSON, Stacey

IPC分类号： A61B5/145 ,  A61M5/00 ,  G01N33/50 ,  G05B23/02 ,  G16H10/60

公开(公告)号：EP3616613A1

公开(公告)日：2020-03-04

申请号：EP19203101.1

申请日：2008-06-20

申请人： The University of Virginia Patent Foundation

发明人： PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： A61B5/145 ,  A61M5/172 ,  G16H20/17 ,  G16H40/63 ,  G16H50/20

摘要： A method for determining insulin dosing recommendation comprising: measuring blood glucose concentration in a patient at multiple actuation times; applying an adaptive observer scheme to estimate a present physiological state of a patient based on the measurements of blood glucose concentration in the patient, wherein the adaptive observer scheme models the present physiological state of the patient using a dynamic model; and applying the estimated physiological state to a Linear Quadratic regulator to determine an insulin dosing recommendation based on the present physiological state so estimated.

公开(公告)号：EP2435962A1

公开(公告)日：2012-04-04

申请号：EP10781299.2

申请日：2010-05-28

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  PATEK, Stephen D. ,  BRETON, Marc D.

IPC分类号： G06Q10/00

CPC分类号： G06F19/3456 ,  G06F19/00 ,  G06F19/3475 ,  G06F19/3481 ,  G16H50/20 ,  G16H50/50

摘要： A structure, method, and computer program product for a diabetes control system provides, but is not limited thereto, the following: open-loop or closed-loop control of diabetes that adapts to individual physiologic characteristics and to the behavioral profile of each person. An exemplary aspect to this adaptation is biosystem (patient or subject) observation and modular control. Consequently, established is the fundamental architecture and the principal components for a modular system, which may include algorithmic observers of patients' behavior and metabolic state, as well as interacting control modules responsible for basal rate, insulin boluses, and hypoglycemia prevention.