专利检索 ap:("University of South Carolina Research Foundation") AND inv:"MACALLISTER, Thomas" 第 1 页

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发明公开
CLONING OF CORYNEBACTERIACEAE HISTIDINE AMMONIA LYASE AND THERAPEUTIC USES 审中-公开
标题翻译：克隆Corynebacteriaceae组氨酸解氨酶和治疗用途

公开(公告)号：EP1280924A2

公开(公告)日：2003-02-05

申请号：EP01930503.6

申请日：2001-04-13

申请人： University of South Carolina Research Foundation

发明人： SETHURAMAN, Natarajan , ROBERTS, Joseph , MACALLISTER, Thomas

IPC分类号： C12N15/60 , C12N9/88 , A61K38/51 , A61K31/41 , A61K31/711 , A61P31/12 , A61P37/06

CPC分类号： C12N9/88 , A61K38/00 , A61K48/00 , C12Y403/01003 , Y02A50/471

摘要： Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result, histidine ammonia lyases similar to the one isolated from Corynebacteriaceae are uniquely suitable for combination therapy with L-histidinol to treat histidine- and/or histamine-dependent pathologies, for example, infectious viruses, such as human Respiratory Syncytial Virus (RSV), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV), as well as cancers.