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公开(公告)号：EP2904100A1
公开(公告)日：2015-08-12
申请号：EP13773256.6
申请日：2013-10-04
申请人： Biochemtex S.p.A.
发明人： BRANDUARDI, Paola , PORRO, Danilo
CPC分类号： C12N9/88 , C12P7/10 , C12Y403/01003 , C12Y403/01023 , C12Y403/01024 , C12Y403/01025 , Y02E50/16
摘要： It is disclosed a non-naturally occurring microbial organism comprising at least one exogenous nucleic acid encoding an enzyme, or a portion thereof, selected from the group of ammonia lyase. Preferably, the enzyme is PAL3, and the at least one exogenous nucleic acid is obtained from
Arabidopsis thaliana . The non-naturally occurring microbial organism has an increased resistance to biochemical stress compared to the starting microbial organism, as induced for instance by oxidative stress or organic acid stress. Preferably, the non-naturally occurring microbial organism is a yeast and it may be used for fermenting a carbon source obtained from a ligno-cellulosic feedstock.摘要翻译： 公开了一种非天然存在的微生物生物体，其包含至少一种编码选自氨裂解酶的酶或其一部分的外源核酸。 优选地，酶是PAL3，并且所述至少一种外源核酸从拟南芥获得。 非天然存在的微生物生物体与起始的微生物有关，比如通过氧化应激或有机酸胁迫诱导，对生物化学应激的抵抗力增加。 优选地，非天然存在的微生物是酵母，并且可以用于发酵从木质纤维素原料获得的碳源。
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2.发明公开CLONING OF CORYNEBACTERIACEAE HISTIDINE AMMONIA LYASE AND THERAPEUTIC USES 审中-公开克隆Corynebacteriaceae组氨酸解氨酶和治疗用途
公开(公告)号：EP1280924A2
公开(公告)日：2003-02-05
申请号：EP01930503.6
申请日：2001-04-13
CPC分类号： C12N9/88 , A61K38/00 , A61K48/00 , C12Y403/01003 , Y02A50/471
摘要： Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result, histidine ammonia lyases similar to the one isolated from Corynebacteriaceae are uniquely suitable for combination therapy with L-histidinol to treat histidine- and/or histamine-dependent pathologies, for example, infectious viruses, such as human Respiratory Syncytial Virus (RSV), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV), as well as cancers.
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