专利检索 ap:("University of Utah Research Foundation") AND inv:"YOCKMAN, James, W." 第 1 页

1.

发明授权
CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY 有权
标题翻译：还原聚（AMIDOETHYLENIMIN）EN裂变改进改型NUCLEOTIDZUFUHR

公开(公告)号：EP2215147B1

公开(公告)日：2014-04-16

申请号：EP08848029.8

申请日：2008-11-07

申请人： University of Utah Research Foundation

发明人： YOCKMAN, James, W. , BRUMBACH, Jonathan , CHRISTENSEN, Lane, V. , KIM, Sung, Wan

IPC分类号： C08G65/48 , C08G65/34 , C08G65/32 , C08L71/00 , C08L71/08 , C07H21/00 , A61K31/7105

CPC分类号： C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/3342 , C08G65/3346 , C08G65/3348 , C08G73/0253 , C08G73/028 , C08L2205/05

2.

发明公开
CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY 有权
标题翻译：还原聚（AMIDOETHYLENIMIN）EN裂变改进改型NUCLEOTIDZUFUHR

公开(公告)号：EP2215147A2

公开(公告)日：2010-08-11

申请号：EP08848029.8

申请日：2008-11-07

申请人： University of Utah Research Foundation

发明人： YOCKMAN, James, W. , BRUMBACH, Jonathan , CHRISTENSEN, Lane, V. , KIM, Sung, Wan

IPC分类号： C08G65/48 , C08G65/34 , C08G65/32 , C08L71/00 , C08L71/08 , C07H21/00 , A61K31/7105

CPC分类号： C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/3342 , C08G65/3346 , C08G65/3348 , C08G73/0253 , C08G73/028 , C08L2205/05

摘要： Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly (triethyenetetramine/cystamine bisacrylamide) copolymer (poly (TETA/CBA) ). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly (TETA/CBA) -PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.