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1.发明公开ARGININE-GRAFTED BIOREDUCIBLE POLYMER SYSTEMS AND USE IN TREATMENT OF CARDIAC CONDITIONS 审中-公开ARGININGEPFROPFTE BIOREDUZIERBARE POLYMERSYSTEME UND VERWENDUNG BEI DER BEHANDLUNG VON HERZERKRANKUNGEN
公开(公告)号：EP2996676A1
公开(公告)日：2016-03-23
申请号：EP14798171.6
申请日：2014-05-14
发明人： KIM, Sung, Wan , LEE, Young, Sook , LEE, Minhyung
IPC分类号： A61K9/14
CPC分类号： C08G75/14 , A61K31/795 , A61K47/59 , A61K47/6935 , A61K48/0041 , A61K48/005 , C08G69/42 , C08G73/0253 , C08G73/028
摘要： phEPO/ABP polyplexes and methods for the use thereof are disclosed and described. In one embodiment, a phEPO/ABP polyplex may be administered to a subject in a therapeutically effective amount to treat or prevent a cardiac condition. Administration may 5 be made, in some aspects, by intramyocardial injection of a composition or solution containing the phEPO/ABP polyplex.
摘要翻译： 公开和描述了phEPO / ABP复合物及其使用方法。 在一个实施方案中，可以以治疗有效量向对象施用phEPO / ABP聚合物，以治疗或预防心脏病症。 在某些方面，可以通过心肌内注射含有phEPO / ABP聚合物的组合物或溶液来进行给药。
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公开(公告)号：EP1594549B1
公开(公告)日：2010-01-27
申请号：EP04713771.6
申请日：2004-02-23
发明人： LEE, Minhyung , KIM, Sung, Wan
CPC分类号： C07K14/52 , A61K48/0058 , C12N15/85 , C12N2830/002
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3.发明公开INJECTABLE BIODEGRADABLE BLOCK COPOLYMER GELS FOR USE IN DRUG DELIVERY 审中-公开注射生物可降解嵌段共聚物的凝胶FOR USE IN药品管理
公开(公告)号：EP1024790A1
公开(公告)日：2000-08-09
申请号：EP98940801.8
申请日：1998-08-08
CPC分类号： A61K9/0024 , A61K9/1075 , A61K47/34 , C08L71/02 , C08L2666/18
摘要： A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as an aqueous liquid with the resultant formation of a hydrogel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liquid having thermal gelation properties. The copolymer has a gel/sol transition temperature such that, above the body temperature of the animal to which it is administered, it is a solution and when administered and cooled to body temperature it forms a hydrogel. The copolymer is made up of (i) a hydrophobic A polymer block of poly (α-hydroxy acid) and (ii) a hydrophilic B polymer block comprising a poly(ethylene oxide). The drug is released at a controlled rate from the copolymer which biodegrades into non-toxic products. The gel/sol transition temperature and degradation rate can be adjusted by proper selection of the molecular weight and concentration of the poly (α-hydroxy acid) and poly(ethylene oxide) polymer block components.
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公开(公告)号：EP0958369A1
公开(公告)日：1999-11-24
申请号：EP97934981.0
申请日：1997-07-03
CPC分类号： C12N15/1135 , A61K38/00 , A61K47/645 , A61K47/6917 , C12N15/87 , C12N2310/3513 , Y10T428/2984
摘要： A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. Preferred embodiments of the complex have a slightly positive surface charge and an average diameter of about 200 nm. Plasmids and oligonucleotides can be efficiently delivered with such compositions. A method of delivering a selected nucleic acid to a host cell is also disclosed.
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5.发明公开TARGETING OF CONJUGATES OF POLY(ETHYLENE GLYCOL) AND ANTIBODIES AGAINST GLUTAMIC ACID DECARBOXYLASE TO ISLET CELLS 失效MARKING谷氨酸羧化酶ISLAND细胞与聚乙二醇 - 抗体偶联物
公开(公告)号：EP0869815A1
公开(公告)日：1998-10-14
申请号：EP96935913.0
申请日：1996-09-20
发明人： JACOBS, Harvey , KIM, Sung, Wan , MENARD, Virginie
CPC分类号： C07K16/40 , A61K38/00 , A61K39/44 , A61K47/60 , A61K47/6871 , C07K2317/55
摘要： A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.
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6.发明授权CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY 有权还原聚（AMIDOETHYLENIMIN）EN裂变改进改型NUCLEOTIDZUFUHR
公开(公告)号：EP2215147B1
公开(公告)日：2014-04-16
申请号：EP08848029.8
申请日：2008-11-07
CPC分类号： C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/3342 , C08G65/3346 , C08G65/3348 , C08G73/0253 , C08G73/028 , C08L2205/05
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7.发明公开CLEAVABLE MODIFICATIONS TO REDUCIBLE POLY(AMIDO ETHYLENIMINE)S TO ENHANCE NUCLEOTIDE DELIVERY 有权还原聚（AMIDOETHYLENIMIN）EN裂变改进改型NUCLEOTIDZUFUHR
公开(公告)号：EP2215147A2
公开(公告)日：2010-08-11
申请号：EP08848029.8
申请日：2008-11-07
CPC分类号： C08G65/3322 , C08G65/33306 , C08G65/33324 , C08G65/3342 , C08G65/3346 , C08G65/3348 , C08G73/0253 , C08G73/028 , C08L2205/05
摘要： Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly (triethyenetetramine/cystamine bisacrylamide) copolymer (poly (TETA/CBA) ). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly (TETA/CBA) -PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.
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公开(公告)号：EP1594549A2
公开(公告)日：2005-11-16
申请号：EP04713771.6
申请日：2004-02-23
发明人： LEE, Minhyung , KIM, Sung, Wan
CPC分类号： C07K14/52 , A61K48/0058 , C12N15/85 , C12N2830/002
摘要： Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment.
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