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    HYDROPHILIC POLYMER DERIVATIVE HAVING BENZYLIDENE ACETAL LINKER
    4.
    发明公开
    HYDROPHILIC POLYMER DERIVATIVE HAVING BENZYLIDENE ACETAL LINKER 有权
    亲水聚合物衍生物具有苯亚甲基乙酰基链接剂

    公开(公告)号：EP2980116A1

    公开(公告)日：2016-02-03

    申请号：EP14773177.2

    申请日：2014-03-25

    申请人： NOF Corporation

    发明人： TSUBUSAKI Takuma ,  YAMAMOTO Yuji

    IPC分类号： C08G65/331 ,  A61K47/34 ,  A61K47/48 ,  C08G65/333

    CPC分类号： C08G65/48 ,  C08G65/2609 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  C08G65/33348 ,  C08G65/3342

    摘要： Provided is a hydrophilic polymer derivative having a benzylidene acetal linker whose hydrolysis rate at the pH of a weakly acidic environment in the living body can be accurately controlled.
    A hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by the following formula (1):

    wherein R 1 is a hydrogen atom or a hydrocarbon group; R 2 , R 3 , R 4 , R 5 , and R 6 are each independently a hydrogen atom or a substituent and at least one of R 3 , R 4 , and R 5 is an electron-withdrawing substituent or at least one of R 2 and R 6 represents a substituent; X 1 is a chemically reactive functional group; P is a hydrophilic polymer; w is an integer of 1 to 8; and Z 1 and Z 2 are an independently selected divalent spacer.

    摘要翻译： 本发明提供一种具有亚苄基缩醛连接体的亲水性高分子衍生物，其可以准确地控制生物体内的弱酸性环境的pH下的水解速度。 具有亚苄基缩醛连接体的亲水性高分子衍生物，其由下式（1）表示：其中R1是氢原子或烃基; R 2，R 3，R 4，R 5和R 6各自独立地为氢原子或取代基，并且R 3，R 4和R 5中的至少一个为吸电子​​取代基或R 2和R 6中的至少一个表示取代基; X1是化学反应性官能团; P是亲水性聚合物; w是1至8的整数; Z1和Z2是独立选择的二价间隔基。

    Polymeric Tissue Sealant
    6.
    发明公开
    Polymeric Tissue Sealant 审中-公开
    Polymergewebeversiegelungsmittel

    公开(公告)号：EP2537539A1

    公开(公告)日：2012-12-26

    申请号：EP12153260.0

    申请日：2008-04-14

    申请人： Kuros Biosurgery AG

    发明人： Rehor, Annemie ,  Cerritelli, Simona

    IPC分类号： A61L15/58 ,  A61L31/02 ,  C08L71/02

    CPC分类号： A61L24/046 ,  A61K47/34 ,  A61L24/0042 ,  A61L31/06 ,  A61L2400/04 ,  C08G63/00 ,  C08G65/3322 ,  C08G65/33306 ,  C08G65/3342 ,  C08G2650/58 ,  C08L71/02 ,  C08L2666/22

    摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein:
    i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is equal to 2 or greater than 2, preferably 3, 4, 5, 6, 7 or 8;
    ii) the second precursor molecule is of the general formula:

             A-[(C 3 H 6 O) n -(C 2 H 4 O) m -B] i

    wherein m and n are integers from 1 to 200
    i is greater than 2, preferably 3, 4, 5, 6, 7 or 8
    A is a branch point
    B is a conjugated unsaturated group.

    摘要翻译： 用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。 生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物， 其中x等于2或大于2，优选3，4，5，6，7或8; ii）第二前体分子具有以下通式：ƒ€ƒ€ƒ€ƒ€ƒ€ƒA - [（C 3 H 6 O）n - （C 2 H 4 O）m -B ]其中m和n是1至200i的整数大于2，优选3,4,5,6,7或8 A是分支点B是共轭不饱和基团。