公开(公告)号：EP3003398A1

公开(公告)日：2016-04-13

申请号：EP14804718.6

申请日：2014-05-29

申请人： University of Washington through its Center for Commercialization ,  Nexgenia, Inc.

发明人： STAYTON, Patrick S. ,  LAI, Jriuan ,  MONFORT, Dagmara ,  NEHILLA, Barrett James

IPC分类号： A61K49/18

CPC分类号： G01N33/54333 ,  A61K49/1839 ,  G01N2446/20 ,  G01N2446/84

摘要： The present disclosure provides stimuli-responsive magnetic nanoparticles, methods of making the magnetic nanoparticles, and methods of using the magnetic nanoparticles. The magnetic nanoparticles include a metal oxide core; and a shell that includes a stimuli-responsive polymer having a terminal group that directly coordinates to the metal oxide core. The stimuli-responsive polymer does not include a micelle-forming group, at least at a proximal terminus of the polymer, with respect to the metal oxide core.

摘要翻译： 本公开提供了刺激响应磁性纳米颗粒，制备磁性纳米颗粒的方法和使用磁性纳米颗粒的方法。 磁性纳米颗粒包括金属氧化物核; 以及包含具有直接与金属氧化物核心配位的末端基团的刺激响应型聚合物的壳。 相对于金属氧化物核，刺激响应性聚合物至少在聚合物的近端处不包括胶束形成基团。

公开(公告)号：EP3121598B1

公开(公告)日：2019-01-02

申请号：EP16176259.6

申请日：2011-05-04

申请人： University of Washington through its Center for Commercialization

发明人： STAYTON, Patrick S. ,  LAI, Jriuan ,  NEHILLA, Barrett J. ,  SRINIVASAN, Selvi

IPC分类号： G01N33/543 ,  B82Y25/00 ,  B01D21/00 ,  G01N27/74

公开(公告)号：EP3121598A1

公开(公告)日：2017-01-25

申请号：EP16176259.6

申请日：2011-05-04

申请人： University of Washington through its Center for Commercialization

发明人： STAYTON, Patrick S. ,  LAI, Jriuan ,  NEHILLA, Barrett J. ,  SRINIVASAN, Selvi

IPC分类号： G01N33/58 ,  G01N33/543 ,  B82Y25/00 ,  B01D21/00 ,  G01N27/74

CPC分类号： B01D21/0009 ,  B82Y25/00 ,  G01N27/745 ,  G01N33/54366 ,  G01N2001/4088 ,  Y02A50/53 ,  Y02A50/58 ,  Y10T436/255

摘要： The present disclosure utilizes the aggregation of stimuli-responsive polymers to isolate a diagnostic target (e.g., an antigen) from a solution using magnetophoresis. Isolating the diagnostic target provides a route to identify the presence of the diagnostic target in the solution. For example, utilized is a two-component assay (eg sandwich assay) comprising a magnetic nanoparticle functionalized with a stimuli-responsive polymer, and a capture molecule attached to a second stimuli-responsive polymer.

摘要翻译： 本公开使用刺激响应聚合物的聚集来使用磁电泳从溶液中分离诊断靶（例如抗原）。 隔离诊断目标提供了一种路径，用于识别解决方案中诊断目标的存在。 例如，所使用的是包含用刺激响应性聚合物官能化的磁性纳米颗粒和连接到第二刺激响应性聚合物的捕获分子的双组分测定（例如夹心测定）。

公开(公告)号：EP3068378A1

公开(公告)日：2016-09-21

申请号：EP14862645.0

申请日：2014-11-12

申请人： University of Washington through its Center for Commercialization

发明人： STAYTON, Patrick S. ,  CONVERTINE, Anthony ,  RATNER, Daniel M. ,  SRINIVASAN, Selvi ,  DAS, Debobrato ,  SU, Fang-Yi ,  CHEN, Jasmin ,  CHIU, David Yee-Shawn ,  LANE, Daniel Douglas

IPC分类号： A61K9/14 ,  A61P31/00

CPC分类号： A61K47/48176 ,  A61K9/1075 ,  A61K9/1271 ,  A61K31/337 ,  A61K31/407 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/7036 ,  A61K47/58 ,  A61K47/60 ,  A61K47/644 ,  A61K47/6907 ,  A61K47/6915

摘要： Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.