公开(公告)号：EP1786896B1

公开(公告)日：2018-01-10

申请号：EP05764227.4

申请日：2005-06-23

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin, Allen ,  AGULNICK, Alan, D. ,  ELIAZER, Susan ,  BAETGE, Emmanuel

IPC分类号： C12N5/071 ,  C12N5/0735 ,  C12Q1/68

CPC分类号： C12N5/0018 ,  A61K35/12 ,  C12N5/0603 ,  C12N5/0606 ,  C12N5/0676 ,  C12N5/0679 ,  C12N15/1086 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2502/02 ,  C12N2502/13 ,  C12N2503/00 ,  C12N2506/02 ,  C12N2510/00 ,  C12Q1/6881 ,  C12Q2600/158

摘要： Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.

公开(公告)号：EP3505622A1

公开(公告)日：2019-07-03

申请号：EP19151982.6

申请日：2005-07-08

申请人： VIACYTE, INC.

发明人： AGULNICK, Alan D. ,  BAETGE, Emmanuel E. ,  D'AMOUR, Kevin Allen ,  ELIAZER, Susan ,  KROON, Evert

IPC分类号： C12N5/073 ,  C12N5/0735

摘要： This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.

公开(公告)号：EP1957636B1

公开(公告)日：2018-07-04

申请号：EP06827129.5

申请日：2006-10-27

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin, Allen ,  AGULNICK, Alan, D. ,  ELIAZER, Susan ,  BAETGE, Emmanuel, E.

IPC分类号： C12N5/0735 ,  C12N5/071 ,  C12N5/073 ,  C07K16/18

CPC分类号： C12N5/0603 ,  C07K16/18 ,  C12N5/0606 ,  C12N5/0676 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/405 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2502/13 ,  C12N2506/02 ,  C12N2510/00

摘要： Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.

公开(公告)号：EP1740612B1

公开(公告)日：2019-08-07

申请号：EP05780039.3

申请日：2005-04-26

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin, Allen ,  AGULNICK, Alan, D. ,  ELIAZER, Susan ,  BAETGE, Emmanuel, E.

IPC分类号： C12N5/0735 ,  C12N5/071

公开(公告)号：EP3584311A1

公开(公告)日：2019-12-25

申请号：EP19179403.1

申请日：2006-10-27

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin ,  AGULNICK, Alan D. ,  ELIAZER, Susan ,  BAETGE, Emmanuel E.

IPC分类号： C12N5/073 ,  C12N5/0735 ,  C07K16/18

摘要： Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.

公开(公告)号：EP1773986B1

公开(公告)日：2019-01-16

申请号：EP05769491.1

申请日：2005-07-08

申请人： VIACYTE, INC.

发明人： D'AMOUR, Kevin, Allen ,  AGULNICK, Alan, D. ,  ELIAZER, Susan ,  KROON, Evert ,  BAETGE, Emmanuel, E.

IPC分类号： C12N5/071 ,  C12N5/0735