公开(公告)号：EP2640419A1

公开(公告)日：2013-09-25

申请号：EP11781825.2

申请日：2011-11-15

申请人： VIB VZW ,  Universiteit Gent

发明人： SAELENS, Xavier ,  SCHEPENS, Bert ,  FIERS, Walter

IPC分类号： A61K39/155 ,  A61P31/12

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C07K16/1027 ,  C07K2317/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N7/02 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or a pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

摘要翻译： 描述了一种针对呼吸道合胞病毒（RSV）的疫苗。 更具体地，描述了包含RSV编码的小疏水（SH）蛋白的胞外域的重组亚单位疫苗。 SH的胞外域被称为SHe。 胞外域通常表现为低聚物或五聚体。 还描述了针对胞外结构域或针对胞外结构域特异性的抗体，以及它们用于保护受试者免受RSV感染和/或用于治疗受感染受试者的用途。

公开(公告)号：EP2640419B1

公开(公告)日：2018-12-05

申请号：EP11781825.2

申请日：2011-11-15

申请人： VIB VZW ,  Universiteit Gent

发明人： SAELENS, Xavier ,  SCHEPENS, Bert ,  FIERS, Walter

IPC分类号： A61K39/155 ,  A61P31/12

CPC分类号： A61K39/155 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/6081 ,  A61K2039/645 ,  C07K7/06 ,  C07K14/005 ,  C07K14/78 ,  C07K16/1027 ,  C07K2317/10 ,  C07K2317/76 ,  C12N7/00 ,  C12N7/02 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or a pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.

公开(公告)号：EP2970446A1

公开(公告)日：2016-01-20

申请号：EP14717681.2

申请日：2014-03-17

申请人： Amgen Research (Munich) GmbH ,  VIB VZW ,  Universiteit Gent

发明人： KUFER, Peter ,  RAUM, Tobias ,  MUENZ, Markus ,  PENDZIALEK, Jochen ,  FIERS, Walter ,  SAELENS, Xavier ,  ROOSE, Kenny

IPC分类号： C07K16/10 ,  C07K16/28 ,  A61K47/48

CPC分类号： C07K16/468 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/1018 ,  C07K16/2809 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

摘要： The present invention relates to an antibody construct comprising a first human binding domain specific for the extracellular part of the influenza envelope protein M2 (M2e) and a second domain specific for CD3. Moreover, the invention provides a nucleic acid molecule encoding the antibody construct, a vector comprising said nucleic acid molecule and a host cell transformed or transfected with said nucleic acid molecule or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a pharmaceutical composition comprising said antibody construct, a medical use / method of treatment relating to said antibody construct, and a kit comprising said antibody construct.

摘要翻译： 本发明涉及包含对流感病毒包膜蛋白M2（M2e）的细胞外部分特异的第一人结合结构域和CD3特异性的第二结构域的抗体构建体。 此外，本发明提供编码抗体构建体的核酸分子，包含所述核酸分子的载体和用所述核酸分子或载体转化或转染的宿主细胞。 此外，本发明提供了制备本发明的抗体构建体的方法，包含所述抗体构建体的药物组合物，与所述抗体构建体有关的医疗用途/治疗方法，以及包含所述抗体构建体的试剂盒。