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公开(公告)号：EP2209367A2
公开(公告)日：2010-07-28
申请号：EP08851037.5
申请日：2008-11-11
发明人： CHIN, Milton
CPC分类号： B01L3/505 , A01N1/0268 , B01L2300/0832
摘要： This invention is a storage device (cryocontainer) for the vitrification method of cryopreservation that uses shape memory materials to create a novel shape-shifting feature in which the relevant heat transfer zone of the cryocontainer can be thermally morphed between a shape conducive to biological specimen handling and to a shape conducive to rapid heat transfer. This feature utilizes the temperature induced phase transformation of shape memory materials. The temperature inducement occurs naturally within the normal temperature changes that occur during vitrification.
摘要翻译： 本发明是一种用于冷冻保存的玻璃化方法的储存装置（低温容器），其使用形状记忆材料来产生新颖的形状偏移特征，其中该低温容器的相关传热区域可以在有利于生物样本处理的形状 并形成有利于快速传热的形状。 此功能利用形状记忆材料的温度感应相变。 温度诱导在玻璃化过程中发生的正常温度变化内自然发生。
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公开(公告)号：EP2210074A1
公开(公告)日：2010-07-28
申请号：EP08849617.9
申请日：2008-11-12
发明人： CHIN, Milton
CPC分类号： G01K5/483 , A01N1/0268 , G01K3/005 , G01K2203/00
摘要： A temperature alert device to warn of imminent devitrification due to warming of a biological specimen that uses shape memory materials. The temperature induced phase transformation of shape memory materials causes a temperature responsive actuator to extend an alert rod upon warming as the specimen temperature approaches the devitrification temperature (e.g. -130°C). The temperature alert device is automatically reset upon immersion in liquid nitrogen.
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公开(公告)号：EP2229581A2
公开(公告)日：2010-09-22
申请号：EP09702523.3
申请日：2009-01-16
发明人： CHIN, Milton
CPC分类号： G01N1/42 , A01N1/0257 , A01N1/0289
摘要： Successful cryopreservation by the vitrification method depends on high chilling speed. Practitioners of vitrification prefer to use liquid nitrogen as the chilling cryogen due to its inherent safety and low cost. Plunging vitrification cryocontainers in to a quiescent pool of liquid nitrogen invariably results in a chilling rate less than the theoretical potential. The shortfall is attributed to the well-known Leidenfrost effect. The purpose of this invention it to provide improve chilling rates during vitrification using liquid nitrogen. One feature of this invention is a contacting device that invokes convective heat transfer principles to increase chilling speed. In another feature of this invention, cryogen velocity is derived from a self-pressurized dewar containing a saturated cryogen. The self-pressurization is achieved by ambient heating of the dewar's contents. In another embodiment, a sub-cooled cryogen, such as propane, is used in tandem with a saturated cryogen, such as LN2, in a self-pressurized dewar.
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公开(公告)号：EP2211610A2
公开(公告)日：2010-08-04
申请号：EP08850462.6
申请日：2008-11-11
发明人： CHIN, Milton
CPC分类号： A01N1/02 , A01N1/0268 , A61B17/425 , A61B50/30 , A61B2050/0067 , A61D19/022
摘要： A closing device to create a seal in a cryocontainer for a biological specimen utilizes the temperature-induced phase transformation of shape memory materials to cause an actuator to toggle between a sealed and unsealed state. The temperature inducement occurs naturally within the normal temperature changes that occur during cryogenic vitrification of biological specimens.
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