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    ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT
    1.
    发明公开
    ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-公开

    公开(公告)号：EP3865870A1

    公开(公告)日：2021-08-18

    申请号：EP21156002.4

    申请日：2015-12-17

    申请人： Ventana Medical Systems, Inc.

    发明人： OTTER, Michael ,  STEVENS, Benjamin ,  BAUER, Daniel

    IPC分类号： G01N29/44 ,  G01N29/07 ,  G01N29/024

    摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

    METHOD FOR TISSUE SAMPLE FIXATION
    5.
    发明公开
    METHOD FOR TISSUE SAMPLE FIXATION 审中-公开
    VERFAHREN ZUR FIXIERUNG VON GEWEBEPROBEN

    公开(公告)号：EP2676118A1

    公开(公告)日：2013-12-25

    申请号：EP12706226.3

    申请日：2012-02-17

    申请人： Ventana Medical Systems, Inc.

    发明人： OTTER, Michael ,  PIERSON, Abbey ,  CHAFIN, David ,  ROBERTS, Esteban

    IPC分类号： G01N1/30

    摘要： An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.

    摘要翻译： 导致第一温度的醛固定溶液第一次接触组织样品，此外，在第二温度高于第一温度的第二温度下使醛固定液接触组织样品。 第一时间段通常为约15分钟至约4小时，第一温度通常为大于0℃至至少15℃。第二温度通常为大于约22℃至 约55℃，第二时间段为约1小时至约4小时。 使用这个过程，改进的组织形态和IHC染色以及翻译后修饰信号的优异保存已经在大约4小时内完成，与室温方案相比，24小时，并且观察到更均匀的形态和抗原保存。

    DIFFUSION MONITORING PROTOCOL FOR OPTIMIZED TISSUE FIXATION
    7.
    发明公开
    DIFFUSION MONITORING PROTOCOL FOR OPTIMIZED TISSUE FIXATION 审中-公开
    扩散监测协议优化组织固定

    公开(公告)号：EP3234583A1

    公开(公告)日：2017-10-25

    申请号：EP15813405.6

    申请日：2015-12-17

    申请人： Ventana Medical Systems, Inc.

    发明人： CHAFIN, David ,  OTTER, Michael ,  BAUER, Daniel

    IPC分类号： G01N29/024 ,  G01N29/07

    摘要： The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative.

    摘要翻译： 本公开内容呈现了用于评估已经从对象移除的组织样本的系统和计算机实现的方法。 评估穿过样品的能量的速度变化以监测处理期间生物样品的变化。 能量速度的变化率与扩散程度有关。 用于执行该方法的系统可以包括输出能量的发射器和被配置为检测发射的能量的接收器。 监测声波的飞行时间和其变化率以确定将组织样本浸入固定剂中的最佳时间。

    COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION
    8.
    发明公开
    COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION 审中-公开
    用于组织固定的组合物，方法和系统

    公开(公告)号：EP3194925A2

    公开(公告)日：2017-07-26

    申请号：EP15775635.4

    申请日：2015-09-14

    申请人： Ventana Medical Systems, Inc.

    发明人： CHAFIN, David ,  OTTER, Michael ,  THEISS, Abbey ,  BAUER, Daniel

    IPC分类号： G01N1/30

    CPC分类号： G01N1/30 ,  G01N1/36 ,  G01N2001/2873 ,  G01N2001/305

    摘要： The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.

    摘要翻译： 本公开涉及使用高浓度醛基固定剂来固定组织样品。 选择醛浓度显着增加固定剂溶液扩散到组织中的速率。 当在双温固定的低温步骤中组合时，实现翻译后修饰蛋白质保存的实质性改进。