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1.发明授权
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公开(公告)号：EP3368885A1
公开(公告)日：2018-09-05
申请号：EP16790939.9
申请日：2016-10-28
IPC分类号： G01N21/35
摘要： A method of evaluating the quality state (such as a fixation status) of a cellular sample is provided. A MIR spectrum (220) of the sample is obtained, and a classification (211) or quantification (231) algorithm is applied to the MIR spectrum to identify features (221) indicative of the quality state and/or to classify the sample. The quality state may then be used to determine whether the sample is appropriate for an analytical method and/or whether remedial processing (such as further fixation) is appropriate.
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公开(公告)号：EP3234583B1
公开(公告)日：2020-08-19
申请号：EP15813405.6
申请日：2015-12-17
发明人： CHAFIN, David , OTTER, Michael , BAUER, Daniel
IPC分类号： G01N29/024 , G01N29/07
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公开(公告)号：EP2676118B1
公开(公告)日：2020-03-18
申请号：EP12706226.3
申请日：2012-02-17
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公开(公告)号：EP3559628A1
公开(公告)日：2019-10-30
申请号：EP17832141.0
申请日：2017-12-21
发明人： CHAFIN, David , OTTER, Michael , BAUER, Daniel
IPC分类号： G01N1/31 , G01N29/024 , G01N29/07 , G01N1/30 , G01N29/44
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6.发明公开METHODS FOR TISSUE SAMPLE FIXATION USING AN EXTENDED SOAK IN ALDEHYDE-BASED FIXATIVE SOLUTIONS 审中-公开用于在基于醛基的固定溶液中使用扩张浸泡的组织样品固定的方法
公开(公告)号：EP3250902A1
公开(公告)日：2017-12-06
申请号：EP16702361.3
申请日：2016-01-25
发明人： CHAFIN, David , OTTER, Michael
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/178 , G01N33/574 , G01N2001/305 , G01N2440/14
摘要： An extended tissue fixation method is provided including at least one soak in a cold aldehyde-based fixative solution followed by a soak in a warm aldehyde-based fixative solution over a period greater than 2 days. Using the processes disclosed herein, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals, e.g. biomarkers, have been accomplished relative to standard room temperature fixation protocols. Moreover, the tissue can be left in the fixative solution up to at least 14 days using these methods, which provides improved flexibility relative to other protocols, enabling fixation to be conducted during transportation, shipping, and over weekends or vacations, while still achieving acceptable staining results.
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公开(公告)号：EP2097730B1
公开(公告)日：2011-10-19
申请号：EP07854484.8
申请日：2007-10-29
CPC分类号： G01N1/2813 , G01N1/312 , G01N35/1002 , G01N35/1065 , G01N35/1081 , G01N2035/00039 , G01N2035/00138
摘要： A platen for contacting a liquid to a surface of a substantially flat substrate is disclosed. The platen includes a liquid application station and a stripping element at an end of the liquid application station, wherein the stripping element includes an intersecting gap and an air barrier. Also disclosed are an apparatus including the platen and a method of using the platen to contact a substrate with a liquid.
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8.发明公开
公开(公告)号：EP4022624A1
公开(公告)日：2022-07-06
申请号：EP20761818.2
申请日：2020-08-26
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公开(公告)号：EP2542883B1
公开(公告)日：2019-10-02
申请号：EP11709549.7
申请日：2011-03-04
IPC分类号： G01N29/024 , G01N29/44 , G01N1/30
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10.发明公开METHODS, SYSTEMS, AND APPARATUSES FOR QUANTITATIVE ANALYSIS OF HETEROGENEOUS BIOMARKER DISTRIBUTION 审中-公开用于定量分析非均匀生物标记分布的方法，系统和装置
公开(公告)号：EP3227830A1
公开(公告)日：2017-10-11
申请号：EP15813713.3
申请日：2015-12-03
发明人： BARNES, Michael , CHAFIN, David , GARSHA, Karl , GROGAN, Thomas M. , ROBERTS, Esteban , STEVENS, Benjamin , VENTURA, Frank , CHEFD'HOTEL, Christophe , SHANMUGAM, Kandavel , GRAY, Joe , RAMUNNO-JOHNSON, Damien , VU, Tothu (Tania)
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/3233 , G06K9/4652 , G06K9/6222 , G06T7/11 , G06T7/90 , G06T2207/10036 , G06T2207/10056 , G06T2207/10064 , G06T2207/20032 , G06T2207/20104 , G06T2207/20152 , G06T2207/30024 , G06T2207/30096
摘要： Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.
摘要翻译： 本文公开了用于检测和描述细胞样品中异质性的方法，系统和装置。 针对细胞样品的图像内的一个或多个感兴趣区域（AOI）生成多个视场（FOV）。 来自每个FOV的高光谱或多光谱数据组织成包含一个或多个z层的图像堆栈，每个z层包含FOV中每个像素处的单个标记的强度数据。 将聚类分析应用于图像堆栈，其中聚类算法对具有跨越z轴的层的可检测标记强度的相似比率的像素进行分组，从而生成具有相似表达模式的多个聚类。
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