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19 条记录 (耗时 0.015 秒)

    ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT
    5.
    发明公开
    ACCURATELY CALCULATING ACOUSTIC TIME-OF-FLIGHT 审中-公开

    公开(公告)号：EP3865870A1

    公开(公告)日：2021-08-18

    申请号：EP21156002.4

    申请日：2015-12-17

    申请人： Ventana Medical Systems, Inc.

    发明人： OTTER, Michael ,  STEVENS, Benjamin ,  BAUER, Daniel

    IPC分类号： G01N29/44 ,  G01N29/07 ,  G01N29/024

    摘要： The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

    DIFFUSION MONITORING PROTOCOL FOR OPTIMIZED TISSUE FIXATION
    8.
    发明公开
    DIFFUSION MONITORING PROTOCOL FOR OPTIMIZED TISSUE FIXATION 审中-公开
    扩散监测协议优化组织固定

    公开(公告)号：EP3234583A1

    公开(公告)日：2017-10-25

    申请号：EP15813405.6

    申请日：2015-12-17

    申请人： Ventana Medical Systems, Inc.

    发明人： CHAFIN, David ,  OTTER, Michael ,  BAUER, Daniel

    IPC分类号： G01N29/024 ,  G01N29/07

    摘要： The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative.

    摘要翻译： 本公开内容呈现了用于评估已经从对象移除的组织样本的系统和计算机实现的方法。 评估穿过样品的能量的速度变化以监测处理期间生物样品的变化。 能量速度的变化率与扩散程度有关。 用于执行该方法的系统可以包括输出能量的发射器和被配置为检测发射的能量的接收器。 监测声波的飞行时间和其变化率以确定将组织样本浸入固定剂中的最佳时间。

    COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION
    9.
    发明公开
    COMPOSITIONS, METHODS, AND SYSTEMS FOR TISSUE FIXATION 审中-公开
    用于组织固定的组合物，方法和系统

    公开(公告)号：EP3194925A2

    公开(公告)日：2017-07-26

    申请号：EP15775635.4

    申请日：2015-09-14

    申请人： Ventana Medical Systems, Inc.

    发明人： CHAFIN, David ,  OTTER, Michael ,  THEISS, Abbey ,  BAUER, Daniel

    IPC分类号： G01N1/30

    CPC分类号： G01N1/30 ,  G01N1/36 ,  G01N2001/2873 ,  G01N2001/305

    摘要： The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.

    摘要翻译： 本公开涉及使用高浓度醛基固定剂来固定组织样品。 选择醛浓度显着增加固定剂溶液扩散到组织中的速率。 当在双温固定的低温步骤中组合时，实现翻译后修饰蛋白质保存的实质性改进。

    SYSTEM AND METHOD FOR SAMPLE PROCESSING
    10.
    发明公开
    SYSTEM AND METHOD FOR SAMPLE PROCESSING 审中-公开

    公开(公告)号：EP4123285A1

    公开(公告)日：2023-01-25

    申请号：EP22171093.2

    申请日：2017-12-21

    申请人： Ventana Medical Systems, Inc.

    发明人： OTTER, Michael ,  BAUER, Daniel

    IPC分类号： G01N1/31 ,  G01N29/024 ,  G01N29/07 ,  G01N1/30 ,  G01N29/44

    摘要： A method and system are described for processing tissues according to particular processing protocols that are established based on time-of-flight measurements as a processing fluid is diffused into a tissue sample. In one embodiment, measurement of the time it takes about 70% ethanol to diffuse into a tissue sample is used to predict the time it will take to diffuse other processing fluids into the same or similar tissue samples. Advantageously, the disclosed method and system can reduce overall processing times and help ensure that only samples that require similar processing conditions are batched together.