公开(公告)号：EP3141252B1

公开(公告)日：2018-07-25

申请号：EP16181549.3

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Inc.

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：EP1881983A1

公开(公告)日：2008-01-30

申请号：EP06770824.8

申请日：2006-05-22

申请人： Vertex Pharmaceuticals, Inc.

发明人： WANNAMAKER, Marion, W. ,  LEDEBOER, Mark, W. ,  PIERCE, Albert, C. ,  WANG, Tiansheng ,  FARMER, Luc, J. ,  MARTINEZ-BOTELLA, Gabriel ,  BEMIS, Guy, W. ,  BETHIEL, Randy, S. ,  COME, Jon, H. ,  ARNOST, Michael, J. ,  SALITURO, Francesco, G. ,  WANG, Jian ,  MARHEFKA, Craig ,  STEWART, Michelle ,  GREEN, Jeremy

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of formula (I) wherein Q, Z, R1 , R2 , and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP2121613A2

公开(公告)日：2009-11-25

申请号：EP08714125.5

申请日：2008-01-30

申请人： Vertex Pharmaceuticals, Inc.

发明人： JIMENEZ, Juan-Miguel ,  BEMIS, Guy ,  MALTAIS, Francois ,  WANG, Tiansheng ,  KNEGTEL, Ronald ,  DAVIS, Chris ,  FRAYSSE, Damien ,  BOYALL, Dean ,  SETTIMO, Luca ,  YOUNG, Stephen ,  MORTIMORE, Michael

IPC分类号： C07D213/73 ,  C07D401/14 ,  C07D409/06 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08 ,  A61K31/444 ,  A61K31/529 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D213/73 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D409/06 ,  C07D409/14 ,  C07D417/06 ,  C07D417/14 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to compounds represented by the following structural formula: (I) useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of μsing the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

公开(公告)号：EP1844050B1

公开(公告)日：2009-01-14

申请号：EP06734381.4

申请日：2006-02-02

申请人： Vertex Pharmaceuticals, Inc.

发明人： LEDEBOER, Mark, W. ,  PIERCE, Albert, C. ,  BEMIS, Guy, W. ,  FARMER, Luc, J. ,  WANG, Tiansheng ,  MESSERSMITH, David ,  DUFFY, John, P. ,  WANG, Jian ,  SALITURO, Francesco, G.

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P7/00 ,  A61P11/00 ,  A61P19/00 ,  A61P37/00

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP1881983B1

公开(公告)日：2012-01-11

申请号：EP06770824.8

申请日：2006-05-22

申请人： Vertex Pharmaceuticals, Inc.

发明人： WANNAMAKER, Marion, W. ,  LEDEBOER, Mark, W. ,  PIERCE, Albert, C. ,  WANG, Tiansheng ,  FARMER, Luc, J. ,  MARTINEZ-BOTELLA, Gabriel ,  BEMIS, Guy, W. ,  BETHIEL, Randy, S. ,  COME, Jon, H. ,  ARNOST, Michael, J. ,  SALITURO, Francesco, G. ,  WANG, Jian ,  MARHEFKA, Craig ,  STEWART, Michelle ,  GREEN, Jeremy

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to compounds of formula (I) wherein Q, Z, R1 , R2 , and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP2079740A2

公开(公告)日：2009-07-22

申请号：EP07872337.6

申请日：2007-10-31

申请人： Vertex Pharmaceuticals, Inc.

发明人： BENNANI, Yousseff ,  WANG, Tiansheng ,  SALITURO, Francesco ,  DUFFY, John

IPC分类号： C07D471/16 ,  C07D471/22 ,  C07D487/16 ,  A61K31/395 ,  A61K31/435 ,  A61K31/495 ,  A61P11/06 ,  A61P37/06

CPC分类号： C07D471/16 ,  C07D471/22 ,  C07D487/16

摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP2464641B1

公开(公告)日：2014-06-25

申请号：EP10745687.3

申请日：2010-08-13

申请人： Vertex Pharmaceuticals Inc.

发明人： WANG, Tiansheng ,  HANZELKA, Brian ,  MUH, Ute ,  BEMIS, Guy ,  ZUCCOLA, Harmon, J.

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D487/04 ,  A61K31/506 ,  A61P31/06

CPC分类号： C07D403/12 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/14 ,  C07D487/16

公开(公告)号：EP2001884A1

公开(公告)日：2008-12-17

申请号：EP07754825.3

申请日：2007-04-05

申请人： Vertex Pharmaceuticals, Inc.

发明人： LEDEBOER, Mark ,  MESSERSMITH, David ,  MALTAIS, Francois ,  GAO, Huai ,  WANG, Tiansheng ,  CAO, Jingrong ,  DUFFY, John ,  MARTINEZ-BOTELLA, Gabriel ,  FORSTER, Cornelia ,  MARONE, Valerie ,  WANNAMAKER, Marion ,  SALITURO, Francesco ,  PIERCE, Albert ,  FARMER, Luc

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula (I): useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP1973911A2

公开(公告)日：2008-10-01

申请号：EP07718337.4

申请日：2007-01-17

申请人： Vertex Pharmaceuticals, Inc.

发明人： FARMER, Luc ,  MARTINEZ-BOTELLA, Gabriel ,  PIERCE, Albert ,  SALITURO, Francesco ,  WANG, Jian ,  WANNAMKER, Marion ,  WANG, Tiansheng

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/53 ,  A61P29/00 ,  C07D495/10 ,  A61K31/517 ,  A61P25/00 ,  A61P37/00

CPC分类号： A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/5377 ,  A61K45/06 ,  C07D471/04 ,  C07D495/10 ,  C07D519/00 ,  C12N9/12 ,  C12Y207/10002

摘要： The present invention relates to azaindole compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP3141252A1

公开(公告)日：2017-03-15

申请号：EP16181549.3

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Inc.

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):

or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

摘要翻译： 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。