公开(公告)号：EP3427738A1

公开(公告)日：2019-01-16

申请号：EP18177481.1

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul ,  CLARK, Michael P. ,  BANDARAGE, Upul K. ,  BETHIEL, Randy S. ,  COURT, John J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John. P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan H. ,  KENNEDY, Joseph M. ,  LEDEBOER, Mark W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, Woods M. ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ):

or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

公开(公告)号：EP1791830B1

公开(公告)日：2010-12-29

申请号：EP05799808.0

申请日：2005-09-19

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： SALITURO, Francesco, G. ,  LEDEBOER, Mark W. ,  LEDFORD, Brian ,  WANG, Jian ,  PIERCE, Albert, C. ,  DUFFY, John, P. ,  MESSERSMITH, David

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P37/08 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods for using the compositions in the treatment of various disorders.

公开(公告)号：EP1663211B1

公开(公告)日：2010-01-20

申请号：EP04780381.2

申请日：2004-08-06

申请人： VERTEX PHARMACEUTICALS INCORPORATED ,  Ledeboer, Mark W. ,  Davies, Robert J.

发明人： ARNOST, Michael J. ,  BEMIS, Guy W. ,  DAVIES, Robert J. ,  FORSTER, Cornelia J. ,  GREY, Ronald, Jr. ,  LEDFORD, Brian ,  MARHEFKA, Craig ,  MESSERSMITH, David ,  PIERCE, Albert C. ,  SALITURO, Francesco ,  WANG, Jian ,  LEDEBOER, Mark W.

IPC分类号： A61K31/4196 ,  C07D249/14 ,  C07D403/12 ,  C07D403/04 ,  C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D417/04 ,  C07D409/04 ,  C07D407/12 ,  C07D413/14 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D249/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04

摘要： The present invention relates to aminotriazole compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.

公开(公告)号：EP1791830A1

公开(公告)日：2007-06-06

申请号：EP05799808.0

申请日：2005-09-19

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： SALITURO, Francesco, G. ,  LEDEBOER, Mark W. ,  LEDFORD, Brian ,  WANG, Jian ,  PIERCE, Albert, C. ,  DUFFY, John, P. ,  MESSERSMITH, David

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/4439 ,  A61K31/506 ,  A61P37/08 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods for using the compositions in the treatment of various disorders.