公开(公告)号：EP2828277A1

公开(公告)日：2015-01-28

申请号：EP13712046.5

申请日：2013-03-11

申请人： Vertex Pharmaceuticals Incorporated

发明人： KULDIPKUMAR, Anuj, K. ,  MEDEK, Ales ,  FERRIS, Lori, Ann ,  MUDUNURI, Praveen ,  JUNG, Young, Chun ,  WILLCOX, David, Richard ,  WALDO, Michael ,  NUGENT, William, Aloysius

IPC分类号： C07H19/06 ,  A61K31/7072 ,  A61P31/14

CPC分类号： C07H19/10 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07B2200/13 ,  C07H19/06 ,  A61K2300/00

摘要： The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, pharmaceutical compositions that can include one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate, and methods of treating or ameliorating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate. Also disclosed herein are methods of treating diseases and/or conditions with one or more solid forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl)ethyl)thiophosphoramidate in combination with one or more other agents.