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公开(公告)号：EP3864413A1
公开(公告)日：2021-08-18
申请号：EP19871323.2
申请日：2019-10-08
发明人： CHOUNG, Rok, Seon , MARIETTA, Eric, V. , JAYARAMAN, Vasanth , KRISHNA, Karthik , MURRAY, Joseph, A.
IPC分类号： G01N33/543 , G01N33/68 , G01N33/564 , C07K7/08
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公开(公告)号：EP3191629A1
公开(公告)日：2017-07-19
申请号：EP15839169.8
申请日：2015-09-10
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , BEI, Kang , WANG, Tianhao , KRISHNA, Karthik , KRISHNAMURTHY, Hari, Krishnan
CPC分类号： G01N33/564 , A61K38/10 , A61K39/00 , C07K7/08 , C40B40/10 , G01N33/6854 , G01N33/6878 , G01N2800/02 , G01N2800/24
摘要： The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
摘要翻译： 本公开内容一般涉及生物标志物和肽阵列，并且更具体地涉及使用肽阵列来鉴定自身免疫性疾病（例如乳糜泻）的生物标志物的方法。 此外，除了使用新型生物标志物的治疗方法之外，还公开了一组具有高灵敏度和特异性的乳糜泻新型生物标志物。
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公开(公告)号：EP3790985A1
公开(公告)日：2021-03-17
申请号：EP19799465.0
申请日：2019-05-09
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , VENUGOPAL, Anirudh , BEI, Kang , WANG, Tianhao , KRISHNA, Karthik , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： C12Q1/68 , C12Q1/6837 , C40B50/00 , C40B50/14
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公开(公告)号：EP3368909A1
公开(公告)日：2018-09-05
申请号：EP16860594.7
申请日：2016-10-25
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan , KRISHNA, Karthik
CPC分类号： G01N1/28 , G01N35/0099 , G01N35/028
摘要： Disclosed herein are methods, tools, pillar plates, and tool assemblies for biomolecular analysis using microarrays that reduces the likelihood of air bubbles being trapped by the microarrays. Embodiments of the tools include two clamps that have a tool mount portion and a grasping portion. The tool mount portion is configured to engage a lifting mechanism of a plate handling robot for moving a pillar plate that include microarrays. The grasping portion is configured to freely suspend the pillar plate at an inclination of a non-zero tilt angle relative to a plane normal to the tool mount portion. Embodiments of pillar plates include two protruding edges on opposite sides of the pillar plate and a plurality of pillars with one or more affixed microarrays. Embodiments of the tool assembly include the tool and the pillar plate, wherein the protruding edges are configured to engage with the grasping portions.
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