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公开(公告)号：EP3864413A1
公开(公告)日：2021-08-18
申请号：EP19871323.2
申请日：2019-10-08
发明人： CHOUNG, Rok, Seon , MARIETTA, Eric, V. , JAYARAMAN, Vasanth , KRISHNA, Karthik , MURRAY, Joseph, A.
IPC分类号： G01N33/543 , G01N33/68 , G01N33/564 , C07K7/08
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公开(公告)号：EP2901159B1
公开(公告)日：2020-02-26
申请号：EP13783134.3
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/543 , C40B30/04 , C40B40/10
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公开(公告)号：EP2920272B1
公开(公告)日：2019-08-21
申请号：EP13798499.3
申请日：2013-11-14
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公开(公告)号：EP3191629A1
公开(公告)日：2017-07-19
申请号：EP15839169.8
申请日：2015-09-10
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , BEI, Kang , WANG, Tianhao , KRISHNA, Karthik , KRISHNAMURTHY, Hari, Krishnan
CPC分类号： G01N33/564 , A61K38/10 , A61K39/00 , C07K7/08 , C40B40/10 , G01N33/6854 , G01N33/6878 , G01N2800/02 , G01N2800/24
摘要： The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
摘要翻译： 本公开内容一般涉及生物标志物和肽阵列，并且更具体地涉及使用肽阵列来鉴定自身免疫性疾病（例如乳糜泻）的生物标志物的方法。 此外，除了使用新型生物标志物的治疗方法之外，还公开了一组具有高灵敏度和特异性的乳糜泻新型生物标志物。
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公开(公告)号：EP2812344A1
公开(公告)日：2014-12-17
申请号：EP13747275.9
申请日：2013-02-07
申请人： Vibrant Holdings LLC
发明人： RAJASEKARAN, John, J. , KRISHNAMURTHY, Hari Krishnan , BEI, Kang , WANG, Tianhao , JAYARAMAN, Vasanth
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00596 , B01J2219/00621 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/54353 , G01N2800/00
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：EP3690442A1
公开(公告)日：2020-08-05
申请号：EP20151803.2
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： G01N33/543
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：EP3617219A1
公开(公告)日：2020-03-04
申请号：EP19185540.2
申请日：2013-11-14
发明人： RAJASEKARAN, John J , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
IPC分类号： C07K1/04 , C07D257/06
摘要： The present invention relates to methods of attaching a coupling molecule (e.g. a peptide, an amino acid, ...) to a substrate comprising a plurality of carboxylic acid groups for linking to a coupling molecule; contacting said substrate with a carboxylic acid activating compound formulation comprising a carbodiimide precursor (i.e. a tetrazole thione), wherein said carbodiimide precursor converts to a carbodiimide upon exposure to electromagnetic radiation at a defined wavelength; selectively exposing said carboxylic acid activating compound formulation to the electromagnetic radiation, thereby generating said carbodiimide and activating the carboxylic acid groups to form carbonyl groups on said substrate at a selectively exposed area; contacting the substrate with a coupling formulation comprising a coupling molecule and a solvent; coupling the coupling molecule to at least one of said plurality of carbonyl groups at said selectively exposed area. The invention also relates to corresponding carboxylic acid activating formulations.
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公开(公告)号：EP3974564A1
公开(公告)日：2022-03-30
申请号：EP21190848.8
申请日：2013-09-30
发明人： RAJASEKARAN, John, J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari, Krishnan
IPC分类号： C40B40/10 , G01N33/543 , C40B40/06 , B01J19/00
摘要： Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
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公开(公告)号：EP2956771B1
公开(公告)日：2020-04-08
申请号：EP14751871.6
申请日：2014-02-17
发明人： RAJASEKARAN, John J. , JAYARAMAN, Vasanth , WANG, Tianhao , BEI, Kang , KRISHNAMURTHY, Hari Krishnan
IPC分类号： G01N33/53 , C12Q1/28 , G01N33/543
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10.发明公开SELECTIVE PHOTO ACTIVATION OF AMINO ACIDS FOR SINGLE STEP PEPTIDE COUPLING 审中-公开SELEKTIVE PHOTOAKTIVIERUNG VONAMINOSÄURENZUR KOPPLUNG EINSTUFIGER PEPTIDE
公开(公告)号：EP3107926A1
公开(公告)日：2016-12-28
申请号：EP15751793.9
申请日：2015-02-23
发明人： JAYARAMAN, Vasanth
摘要： Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
摘要翻译： 本文公开了用于微阵列上的氨基酸和肽合成的制剂，底物和阵列。 在某些实施方案中，公开了制备和使用包括一步偶联（例如用于合成C→N取向的肽）的制剂，底物和阵列的方法。 在一些实施方案中，本文公开了用于将生物分子高效耦合到底物的制剂和方法。
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