-
1.发明授权SUBSTITUTED GAMMA AMINOBUTYRIC ACIDS AS PHARMACEUTICAL AGENTS 失效取代GAMMAAMINOBUTTERSÄUREDERIVATEAS药物
公开(公告)号：EP0937032B1
公开(公告)日：2007-05-09
申请号：EP97945516.9
申请日：1997-10-07
发明人： BRYANS, Justin Stephen , HORWELL, David Christopher , KNEEN, Clare Octavia , WUSTROW, David, Juergen , THORPE, Andrew, John
IPC分类号： C07C229/22 , A61K31/195 , C07C323/58
CPC分类号： C07C323/58 , C07C229/22 , C07C2601/14
摘要： Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammation, and gastrointestinal damage. Processes for the preparation and intermediates useful in the preparation are also disclosed.
-
公开(公告)号：EP1187832A1
公开(公告)日：2002-03-20
申请号：EP00928499.3
申请日：2000-04-28
IPC分类号： C07D413/04 , C07D403/04 , A61K31/4245 , A61K31/41 , A61P25/00
CPC分类号： C07D403/04 , C07D413/04
摘要： The instant invention is a novel series of amino heterocycles useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, and sleep disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed.
摘要翻译： 本发明是用于治疗癫痫，晕厥发作，运动机能减退，颅脑疾病，神经退行性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理性疾病和睡眠障碍的新型一系列氨基杂环。 还公开了用于制备的制备方法和中间体。
-
3.发明授权MONO-SUBSTITUTED 3-PROPYL GAMMA-AMINOBUTYRIC ACIDS 有权MONO-SUBSTITUIERTE 3-PROPYL-GAMMA-AMINOBUTTERSÄURE
公开(公告)号：EP1192125B9
公开(公告)日：2009-09-16
申请号：EP00938022.1
申请日：2000-05-31
发明人： BELLIOTTI, Thomas, Richard , BRYANS, Justin, Stephen , EKHATO, Ihoezo, Victor , OSUMA, Augustine, Tobi , SCHELKUN, Robert, Michael , THORPE, Andrew, John , WISE, Lawrence, David , WUSTROW, David, Juergen , YUEN, Po-Wai , SCHWARZ, Jacob,Bradley
IPC分类号： C07C229/08 , A61K31/197 , C07C229/30 , C07C229/22 , C07C229/34 , C07C229/32 , C07C229/20 , A61P25/00 , A61P1/00
CPC分类号： C07C229/34 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
摘要翻译： 本发明是一系列式（I）的新颖的单取代和二取代的3-丙基γ-氨基丁酸。 这些化合物可用作治疗癫痫，微弱发作，运动功能减退，颅内疾病，神经变性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，关节炎，睡眠障碍，IBS和胃损伤的治疗剂。 制备化合物和有用的中间体的方法也是本发明的一部分。
-
公开(公告)号：EP1032555B1
公开(公告)日：2006-04-12
申请号：EP98950649.8
申请日：1998-09-23
发明人： BRYANS, Justin Stephen , HORWELL, David Christopher , THORPE, Andrew, John , WUSTROW, David, Juergen , YUEN, Po-Wai
IPC分类号： C07C229/28 , C07C229/34 , A61K31/195
CPC分类号： C07D221/20 , C07C49/417 , C07C69/608 , C07C69/612 , C07C205/51 , C07C205/53 , C07C229/28 , C07C229/34 , C07C2601/04 , C07C2601/08 , C07C2602/50 , C07D209/96 , C07D307/94 , C07D311/96
摘要： The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
-
公开(公告)号：EP1192125A2
公开(公告)日：2002-04-03
申请号：EP00938022.1
申请日：2000-05-31
发明人： BELLIOTTI, Thomas, Richard , BRYANS, Justin, Stephen , EKHATO, Ihoezo, Victor , OSUMA, Augustine, Tobi , SCHELKUN, Robert, Michael , THORPE, Andrew, John , WISE, Lawrence, David , WUSTROW, David, Juergen , YUEN, Po-Wai , SCHWARZ, Jacop, Bradley
IPC分类号： C07C229/08 , A61K31/197 , C07C229/30 , C07C229/22 , C07C229/34 , C07C229/32 , C07C229/20 , A61P25/00 , A61P1/00
CPC分类号： C07C229/34 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
-
公开(公告)号：EP1192125B1
公开(公告)日：2008-12-31
申请号：EP00938022.1
申请日：2000-05-31
发明人： BELLIOTTI, Thomas, Richard , BRYANS, Justin, Stephen , EKHATO, Ihoezo, Victor , OSUMA, Augustine, Tobi , SCHELKUN, Robert, Michael , THORPE, Andrew, John , WISE, Lawrence, David , WUSTROW, David, Juergen , YUEN, Po-Wai , SCHWARZ, Jacob,Bradley
IPC分类号： C07C229/08 , A61K31/197 , C07C229/30 , C07C229/22 , C07C229/34 , C07C229/32 , C07C229/20 , A61P25/00 , A61P1/00
CPC分类号： C07C229/34 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula (I). The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
-
公开(公告)号：EP1187832B1
公开(公告)日：2002-11-20
申请号：EP00928499.3
申请日：2000-04-28
IPC分类号： C07D413/04 , C07D403/04 , A61K31/4245 , A61K31/41 , A61P25/00
CPC分类号： C07D403/04 , C07D413/04
-
8.发明公开CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF USEFUL AS PHARMACEUTICAL AGENTS 有权ZYKLISCHEAMINOSÄURENUND DEREN DERIVATE ALS ARZNEIMITTEL
公开(公告)号：EP1032555A1
公开(公告)日：2000-09-06
申请号：EP98950649.8
申请日：1998-09-23
发明人： BRYANS, Justin Stephen , HORWELL, David Christopher , THORPE, Andrew, John , WUSTROW, David, Juergen , YUEN, Po-Wai
IPC分类号： C07C229/28 , C07C229/34 , A61K31/195
CPC分类号： C07D221/20 , C07C49/417 , C07C69/608 , C07C69/612 , C07C205/51 , C07C205/53 , C07C229/28 , C07C229/34 , C07C2601/04 , C07C2601/08 , C07C2602/50 , C07D209/96 , C07D307/94 , C07D311/96
摘要： The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
摘要翻译： 本发明是可用于治疗癫痫，微弱发作，神经退行性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，胃肠道疾病如肠易激综合征（IBS）和炎症的新一系列环状氨基酸， 特别是关节炎。 包括含有本发明化合物的药物组合物以及制备化合物的方法和用于制备最终化合物的新中间体。
-
公开(公告)号：EP0937032A1
公开(公告)日：1999-08-25
申请号：EP97945516.0
申请日：1997-10-07
发明人： BRYANS, Justin Stephen , HORWELL, David Christopher , KNEEN, Clare Octavia , WUSTROW, David, Juergen , THORPE, Andrew, John
CPC分类号： C07C323/58 , C07C229/22 , C07C2601/14
摘要： Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, inflammation, and gastrointestinal damage. Processes for the preparation and intermediates useful in the preparation are also disclosed.
摘要翻译： 公开了式（I）的新型γ-氨基丁酸并且可用作治疗癫痫，昏厥发作，运动机能减退，颅障碍，神经退行性障碍，抑郁症，焦虑症，恐慌症，疼痛，神经病理性障碍，炎症和胃肠损伤的药剂。 还公开了用于制备的制备方法和中间体。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.017 秒)
