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公开(公告)号：EP1009399A1
公开(公告)日：2000-06-21
申请号：EP98945758.5
申请日：1998-08-18
发明人： GUGLIETTA, Antonio , TAYLOR, Charles, Price, Jr. , REN, Jiayuan , WATSON, W. P. , RAFFERTY, Michael, Francis , DIOP, Laurent , CHOVET, Maria , BUENO, Lionel , LITTLE, Hilary J.
IPC分类号： A61K31/195
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： GABA analogs are useful to prevent and treat gastrointestinal damage and ethanol withdrawal syndrome. Preferred treatments employ gabapentin or pregabalin.
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公开(公告)号：EP1009399B1
公开(公告)日：2010-03-24
申请号：EP98945758.5
申请日：1998-08-18
发明人： GUGLIETTA, Antonio , TAYLOR, Charles, Price, Jr. , REN, Jiayuan , WATSON, W. P. , RAFFERTY, Michael, Francis , DIOP, Laurent , CHOVET, Maria , BUENO, Lionel , LITTLE, Hilary J.
IPC分类号： A61K31/195 , A61P1/00
CPC分类号： A61K31/42 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/405 , A61K31/54 , A61K31/60 , A61K45/06 , A61K31/19 , A61K2300/00
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3.发明公开PHARMACEUTICAL PREPARATION CONTAINING AN URICOSURIC AND AN EXCITATORY AMINO ACID ANTAGONIST 失效药物组合，制备将URICOSURICHES剂对兴奋性氨基酸拮抗剂包含的内容。
公开(公告)号：EP0603301A1
公开(公告)日：1994-06-29
申请号：EP92919882.0
申请日：1992-09-02
发明人： BIGGE, Christopher, Franklin , JOHNSON, Graham , TAYLOR, Charles, Price, Jr. , WELTY, Devin, Franklin
CPC分类号： A61K31/675 , A61K31/18 , A61K31/47 , A61K31/495 , A61K45/06 , A61K31/19 , A61K2300/00
摘要： The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a disease advantageously affected by treatment with an excitatory amino acid antagonist.
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4.发明授权USE OF GABA ANALOGS SUCH AS GABAPENTIN IN THE MANUFACTURE OF A MEDICAMENT FOR TREATING INFLAMMATORY DISEASES 失效GABA类似物加巴喷丁用于生产药物炎症疾病的治疗
公开(公告)号：EP0994704B1
公开(公告)日：2005-06-15
申请号：EP98934170.6
申请日：1998-06-24
IPC分类号： A61K31/195 , A61P19/02 , A61P29/00
CPC分类号： A61K31/197 , A61K31/195
摘要： GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.
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5.发明公开COMBINATIONS OF AN ALPHA-2-DELTA LIGAND WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 审中-公开α-2-Δ配位体与选择性环氧合酶-2抑制剂联合
公开(公告)号：EP1480639A1
公开(公告)日：2004-12-01
申请号：EP03742460.3
申请日：2003-02-12
IPC分类号： A61K31/42
CPC分类号： A61K31/195 , A61K31/42 , A61K31/4245 , A61K2300/00
摘要： The invention relates to a combination, comprising a selective inhibitor of COX-2, or a phamaceutically acceptable salt thereof, and an Alpha-2-delta ligand, or a pharmaceutically acceptable salt thereof, and valdecoxib. Examples of slective inhibitors of COX-2 include valdecoxib, rofecoxib, and celecoxib. Exampoes of Alpha-2 delta ligands include gabapentin, pregabalin (3S, 4S)-(1-Aminomethyl-3,4-dimethyl-cyclopentyl)-acetic acid, and 3-(1-aminomethyl-cyclohexymethyl)-4H-[1,2,4]oxadiazol-5-one hydrochloride. The combinations are useful for treating certain diseases inclduing cartilage damage, inflammation, pain, and arthritis.
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6.发明公开USE OF GABA ANALOGS SUCH AS GABAPENTIN IN THE MANUFACTURE OF A MEDICAMENT FOR TREATING INFLAMMATORY DISEASES 失效GABA类似物加巴喷丁用于生产药物炎症疾病的治疗
公开(公告)号：EP0994704A1
公开(公告)日：2000-04-26
申请号：EP98934170.6
申请日：1998-06-24
IPC分类号： A61K31/195
CPC分类号： A61K31/197 , A61K31/195
摘要： GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases.
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