公开(公告)号：EP0607309A1

公开(公告)日：1994-07-27

申请号：EP92921896.0

申请日：1992-10-05

申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ,  THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： DRANOFF, Glenn ,  MULLIGAN, Richard C. ,  PARDOLL, Drew

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61P35 ,  A61P37 ,  C07K14 ,  C12N5 ,  C12P21 ,  A61K48 ,  C12R1

CPC分类号： C12N15/85 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55522 ,  C07K14/52 ,  C12N2740/16034

摘要： A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enchanted systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.

公开(公告)号：EP0831925A1

公开(公告)日：1998-04-01

申请号：EP96917935.0

申请日：1996-06-03

申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ,  THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： DRANOFF, Glenn ,  MULLIGAN, Richard C. ,  PARDOLL, Drew

IPC分类号： C12N15 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07K14 ,  C12N5

CPC分类号： A61K39/21 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55522 ,  A61K2039/57 ,  C07K14/52 ,  C07K14/525 ,  C07K14/535 ,  C07K14/5406 ,  C07K14/5409 ,  C07K14/5412 ,  C07K14/545 ,  C07K14/55 ,  C07K14/57 ,  C07K14/705 ,  C07K14/70507 ,  C07K14/70525 ,  C12N15/85 ,  C12N2740/13034 ,  C12N2799/027 ,  C12N2840/44

摘要： A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine, an adhesion or accessory molecule, and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enhanced systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.

公开(公告)号：EP0607309B1

公开(公告)日：2003-01-08

申请号：EP92921896.4

申请日：1992-10-05

申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ,  THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： DRANOFF, Glenn ,  MULLIGAN, Richard C. ,  PARDOLL, Drew

IPC分类号： A61K48/00 ,  A61K39/00 ,  A61P37/02 ,  C12N5/10

CPC分类号： C12N15/85 ,  A61K38/00 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55522 ,  C07K14/52 ,  C12N2740/16034

摘要： A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The target antigen may be a tumor cell, a tumor cell antigen, an infectious agent or other foreign antigen, or other antigens to which an enchanted systemic immune response is desirable. Alternatively, the antigen may be a non-foreign antigen when a suppression of a systemic immune response is desired. The resulting systemic immune response is specific for the target antigen.