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公开(公告)号：EP0804164A2
公开(公告)日：1997-11-05
申请号：EP95938205.0
申请日：1995-02-02
CPC分类号： A61K9/0024
摘要： The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred implant according to the invention is one that becomes gradually disintegrated in situ the animal. The implant provides for extended sustained delivery of the immunogenic agent into surrounding tissue fluids in the presence of circulating maternal antibodies to provide a priming dose of the immunogenic agent to stimulate substantially immediate antibody production for active immunity against a pathogen when passive protection is no longer provided by circulating maternal antibodies.
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公开(公告)号：EP0749321A1
公开(公告)日：1996-12-27
申请号：EP95911683.0
申请日：1995-02-09
申请人： WILLMAR POULTRY COMPANY, INC. , Emery, Daryll A. , Straub, Darren E. , Huisinga, Richard , Carlson, Beth A.
CPC分类号： C07K14/245 , A61K39/0258 , A61K39/0275 , A61K39/102 , G01N33/56911 , G01N33/56916 , Y02A50/474 , Y02A50/482 , Y10S424/823 , Y10S424/824 , Y10S424/825 , Y10S424/826 , Y10S530/825
摘要： The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
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公开(公告)号：EP0804164B1
公开(公告)日：2002-08-14
申请号：EP95938205.2
申请日：1995-10-03
CPC分类号： A61K9/0024
摘要： The invention provides a method of priming an immune response in the presence of maternal antibody in a young animal by administering to a 1-90 day old animal, a biocompatible and non-toxic solid phase implant containing an immunogenic agent. A preferred implant according to the invention is one that becomes gradually disintegrated in situ the animal. The implant provides for extended sustained delivery of the immunogenic agent into surrounding tissue fluids in the presence of circulating maternal antibodies to provide a priming dose of the immunogenic agent to stimulate substantially immediate antibody production for active immunity against a pathogen when passive protection is no longer provided by circulating maternal antibodies.
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