公开(公告)号：EP1255562A2

公开(公告)日：2002-11-13

申请号：EP01921281.0

申请日：2001-02-13

申请人： Vlaams Interuniversitair Instituut voor Biotechnologie vzw.

发明人： REVETS, Hilde ,  CORNELIS, Pierre ,  DE BAETSELIER, Patrick

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K2039/523 ,  A61K2039/55544 ,  A61K2039/57 ,  C07K14/21 ,  C07K14/44 ,  C07K16/10 ,  C07K2319/00 ,  Y02A50/41 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S424/828 ,  Y10S424/829

摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.

公开(公告)号：EP0036995B1

公开(公告)日：1983-12-28

申请号：EP81101921.5

申请日：1981-03-16

申请人： NORDEN LABORATORIES, INC.

发明人： Kucera, Carrell John

IPC分类号： A61K39/102 ,  C12N15/00

CPC分类号： C12N15/01 ,  A61K39/102 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825

公开(公告)号：EP1353689B1

公开(公告)日：2006-04-05

申请号：EP02705685.2

申请日：2002-01-03

申请人： Epitopix LLC

发明人： EMERY, Daryll, A. ,  STRAUB, Darren, E. ,  ZAMMERT, Donavan, E. ,  KALLEVIG, Gayla, K.

IPC分类号： A61K39/108 ,  A61K39/112 ,  A61P37/04

CPC分类号： A61K39/0275 ,  A61K31/739 ,  A61K39/085 ,  A61K39/39 ,  A61K2039/552 ,  A61K2039/55572 ,  C07K14/24 ,  G01N33/53 ,  Y02A50/482 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S424/827 ,  Y10S424/828 ,  Y10S424/829

摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.

摘要翻译： 本发明提供了包含来自革兰氏阴性微生物的铁载体受体多肽和孔蛋白的组合物，并且优选地，脂多糖以不超过约10.0内毒素单位/毫升的浓度存在。 本发明还提供了制备这些组合物的方法和使用方法。

公开(公告)号：EP0749321A4

公开(公告)日：2001-04-25

申请号：EP95911683

申请日：1995-02-09

申请人： WILLMAR POULTRY CO INC ,  EMERY DARYLL A ,  STRAUB DARREN E ,  HUISINGA RICHARD ,  CARLSON BETH A

发明人： EMERY DARYLL A ,  STRAUB DARREN E ,  HUISINGA RICHARD ,  CARLSON BETH A

IPC分类号： A61K39/102 ,  A61P31/04 ,  G01N33/569 ,  A61K39/00 ,  A61K39/104 ,  A61K39/108 ,  A61K39/112 ,  A61K39/38 ,  A61K39/395 ,  A61K39/40 ,  C07K16/12

CPC分类号： C07K14/245 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/102 ,  G01N33/56911 ,  G01N33/56916 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S530/825

摘要： The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.

公开(公告)号：EP1361867B1

公开(公告)日：2007-03-21

申请号：EP01932584.4

申请日：2001-04-20

申请人： Jagotec AG

发明人： GUIVARC'H, Pol-Henri ,  PARIKH, Indu ,  SNOW, Robert, A.

IPC分类号： A61K9/14 ,  A61K31/366 ,  A61P3/06 ,  A61K31/216

CPC分类号： A61K45/06 ,  A61K9/145 ,  A61K9/1623 ,  A61K31/216 ,  A61K31/22 ,  A61K31/365 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/505 ,  A61K31/66 ,  Y10S424/824 ,  Y10S977/906 ,  A61K2300/00

摘要： This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80 % of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.

公开(公告)号：EP0020356B1

公开(公告)日：1983-02-09

申请号：EP79900915.4

申请日：1979-08-16

申请人： NATIONAL RESEARCH DEVELOPMENT CORPORATION

发明人： GILMOUR, Neil James Livingstone ,  MARTIN, William Barr ,  SHARP, James Michael ,  THOMPSON, Dennis Arthur ,  WELLS, Peter William

IPC分类号： A61K39/102 ,  A61K39/116

CPC分类号： A61K39/102 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55566 ,  Y10S424/823 ,  Y10S424/824

摘要： A pasteurella vaccine e.g. for use with cattle or particularly sheep, comprises antigenic material derived from the A1 and A2 serotypes of Pasteurella haemolytica. the A1 serotype antigenic material comprising capsular extract, e.g. especially salicylate extract, and the A2 serotype antigenic material comprising heat-killed whole organisms, and a process for the production of a pasteurellosis vaccine comprises preparing said antigenic material from P. haemolytica organisms and formulating the antigenic material into a vaccine, e.g. especially an aluminium hydroxide gel/oil adjuvant vaccine. Also a method for use in agricultural animal husbandry for the prevention and control of pasteurellosis in sheep, cattle and other animals comprises vaccinating the animals with a vaccine according to the invention.

摘要翻译： 巴斯德氏菌疫苗例如 用于与牛或特别是绵羊一起使用，包含源自溶血巴斯德氏菌的A1和A2血清型的抗原性物质。 包含荚膜提取物的A1血清型抗原物质，例如， 尤其是水杨酸盐提取物和包含热杀死的全生物体的A2血清型抗原物质，以及用于生产巴斯德菌病疫苗的方法，包括从溶血性巴氏杆菌生物体制备所述抗原物质，并将抗原物质配制成疫苗， 特别是氢氧化铝凝胶/油佐剂疫苗。 用于农业畜牧业的用于预防和控制绵羊，牛和其它动物的巴斯德氏菌病的方法还包括用根据本发明的疫苗给动物接种疫苗。

公开(公告)号：EP0036995A1

公开(公告)日：1981-10-07

申请号：EP81101921.5

申请日：1981-03-16

申请人： NORDEN LABORATORIES, INC.

发明人： Kucera, Carrell John

IPC分类号： A61K39/102 ,  C12N15/00

CPC分类号： C12N15/01 ,  A61K39/102 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825

摘要： The chemical modification of virulent Pasteurella multocida and Pasteurella haemolytica strains and preparation of live bacterial vaccines from the modified organisms for immunization of bovine, porcine and ovine animal species are disclosed.

公开(公告)号：EP1255562B1

公开(公告)日：2008-01-16

申请号：EP01921281.0

申请日：2001-02-13

申请人： Vlaams Interuniversitair Instituut voor Biotechnologie vzw.

发明人： REVETS, Hilde ,  CORNELIS, Pierre ,  DE BAETSELIER, Patrick

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K2039/523 ,  A61K2039/55544 ,  A61K2039/57 ,  C07K14/21 ,  C07K14/44 ,  C07K16/10 ,  C07K2319/00 ,  Y02A50/41 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S424/828 ,  Y10S424/829

摘要： The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.

公开(公告)号：EP0749321A1

公开(公告)日：1996-12-27

申请号：EP95911683.0

申请日：1995-02-09

申请人： WILLMAR POULTRY COMPANY, INC. ,  Emery, Daryll A. ,  Straub, Darren E. ,  Huisinga, Richard ,  Carlson, Beth A.

发明人： EMERY, Daryll A. ,  STRAUB, Darren E. ,  HUISINGA, Richard ,  CARLSON, Beth A.

IPC分类号： A61K39 ,  A61P31 ,  G01N33

CPC分类号： C07K14/245 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/102 ,  G01N33/56911 ,  G01N33/56916 ,  Y02A50/474 ,  Y02A50/482 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S530/825

摘要： The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.

公开(公告)号：EP0020356A1

公开(公告)日：1981-01-07

申请号：EP79900915.0

申请日：1979-08-16

申请人： GILMOUR, Neil James Livingstone ,  MARTIN, William Barr ,  SHARP, James Michael ,  THOMPSON, Dennis Arthur ,  WELLS, Peter William

发明人： GILMOUR, Neil James Livingstone ,  MARTIN, William Barr ,  SHARP, James Michael ,  THOMPSON, Dennis Arthur ,  WELLS, Peter William

IPC分类号： A61K39

CPC分类号： A61K39/102 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55566 ,  Y10S424/823 ,  Y10S424/824

摘要： Un vaccin contre la pasteurellose, par exemple utilisable pour le betail ou en particulier pour les moutons comprend du materiel antigenique derive des serotypes A1 et A2 de Pasteurella hemolytica, l'antigene de serotype A1 comprenant un extrait capsulaire, par exemple un extrait au salicylate, et l'antigene de serotype A2 comprenant des organismes entiers tues par la chaleur, et un procede pour la preparation d'un vaccin contre la pasteurellose comprenant la preparation dudit materiel antigenique a partir d'organismes de P. hemolytica et la formulation du materiel antigenique en un vaccin, par exemple un vaccin contenant un gel d'hydroxyde d'aluminium et une huile adjuvante. Procede d'utilisation en agriculture de l'elevage des animaux pour prevenir et controler la pasteurellose chez les moutons, le betail et autres animaux comprenant la vaccination des animaux avec un vaccin selon l'invention.