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1.发明公开HIGH TITER RECOMBINANT INFLUENZA VIRUSES WITH ENHANCED REPLICATION IN VERO CELLS 审中-公开重组流感高滴度和增强的复制在Vero细胞
公开(公告)号：EP2493912A1
公开(公告)日：2012-09-05
申请号：EP10777154.5
申请日：2010-10-26
摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, and genes from vaccine seed virus isolates which include a HA gene segment with a HA2 sequence encoding a HA2 that confers enhanced growth in cells in culture, such as Vero cells.
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公开(公告)号：EP2493912B1
公开(公告)日：2020-07-29
申请号：EP10777154.5
申请日：2010-10-26
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公开(公告)号：EP2010557B1
公开(公告)日：2014-02-26
申请号：EP07754132.4
申请日：2007-03-29
IPC分类号： C07K14/11
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N9/2402 , C12N15/85 , C12N2760/16051 , C12N2760/16121 , C12N2760/16134 , C12N2760/16151 , C12N2800/107 , C12Y302/01018
摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.
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公开(公告)号：EP2010557A2
公开(公告)日：2009-01-07
申请号：EP07754132.4
申请日：2007-03-29
IPC分类号： C07K14/11
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5254 , C07K14/005 , C12N9/2402 , C12N15/85 , C12N2760/16051 , C12N2760/16121 , C12N2760/16134 , C12N2760/16151 , C12N2800/107 , C12Y302/01018
摘要： The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.
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