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公开(公告)号：EP2939534B1
公开(公告)日：2017-01-25
申请号：EP14001527.2
申请日：2014-04-30
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Surowiecka, Agnieszka
IPC分类号： A01K67/027 , A61K36/77
CPC分类号： A01K67/027 , A01K2207/30 , A01K2227/105 , A01K2267/0306 , A01K2267/0375
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2.发明公开Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制造方法，使用该化合物和药物组合物包含所述化合物
公开(公告)号：EP3061765A1
公开(公告)日：2016-08-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta
CPC分类号： C07J63/008
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
摘要翻译： 本发明涉及一种protoescigenin衍生物具有药理学性质，其制备方法，以及利用搜索化合物作为药物的爱尤其用于治疗血管疾病，以及涉及包含寻求化合物的药物组合物。
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3.发明授权Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制备方法，所述化合物的用途以及包含该化合物的药物组合物
公开(公告)号：EP3061765B1
公开(公告)日：2018-01-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta , Dutkiewicz, Malgorzata
CPC分类号： C07J63/008 , A61K31/58
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
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公开(公告)号：EP2939534A1
公开(公告)日：2015-11-04
申请号：EP14001527.2
申请日：2014-04-30
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Surowiecka, Agnieszka
IPC分类号： A01K67/027 , A61K36/77
CPC分类号： A01K67/027 , A01K2207/30 , A01K2227/105 , A01K2267/0306 , A01K2267/0375
摘要： A non-human animal mammalian model for Parkes-Weber syndrome, wherein an animal has an arteriovenous fistula and a venous ligature in at least one of the limbs, is provided. The invention also relates to a method for preparing the model. The desired model reflects the pathophysiological characteristics of PW syndrome and can be used in studies on PW syndrome, including etiology of the syndrome. The animal model can also be used for screening a material for vascular use and for screening a preventive and/or therapeutic agent for Parkes-Weber syndrome.
摘要翻译： 提供了一种用于Parkes-Weber综合征的非人动物哺乳动物模型，其中动物在至少一个肢体中具有动静脉瘘和静脉结扎。 本发明还涉及一种用于制备该模型的方法。 所需模型反映了PW综合征的病理生理特征，可用于PW综合征的研究，包括综合征病因。 动物模型也可用于筛选用于血管使用的材料和筛选Parkes-Weber综合征的预防和/或治疗剂。
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