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公开(公告)号：EP2939534B1
公开(公告)日：2017-01-25
申请号：EP14001527.2
申请日：2014-04-30
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Surowiecka, Agnieszka
IPC分类号： A01K67/027 , A61K36/77
CPC分类号： A01K67/027 , A01K2207/30 , A01K2227/105 , A01K2267/0306 , A01K2267/0375
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公开(公告)号：EP3124016A1
公开(公告)日：2017-02-01
申请号：EP15460037.3
申请日：2015-07-31
发明人： Zegrocka-Stendel, Oliwia , Huszcza, Grzegorz , Pesta, Edyta , Smedra, Katarzyna , Koziak, Katarzyna
IPC分类号： A61K9/107 , A61K9/113 , A61K47/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18 , A61K31/546
CPC分类号： A61K9/107 , A61K9/113 , A61K31/546 , A61K47/02 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/18
摘要： The present invention relates to the antipsoriatic emulsion composition, especially in the form of a cream, comprising an effective therapeutic dose of cefazolin, the ingredients of the oil phase and the ingredients of the water phase, characterized by that
(i) the ingredients of the oil phase include:
- liquid paraffin or white petrolatum,
- polyoxyethylene stearyl ether (21), and
- cetostearyl alcohol;
(ii) the ingredients of the oil phase include a buffer solution to maintain the pH value of the initial composition from 5 to 9, preferably in the range 6 - 8,
(iii) optionally, comprising an additional amphiphilic nonionic emulsifier, and other soluble/water miscible excipients,
wherein water content accounts for 50 to 80% by weight of the composition.摘要翻译： 本发明涉及抗牛皮癣乳剂组合物，特别是霜剂形式，其包含有效治疗剂量的头孢唑啉，油相的成分和水相的成分，其特征在于（i） 油相包括： - 液体石蜡或白凡士林， - 聚氧乙烯十八烷基醚（21）和 - 十六醇硬脂醇; （ii）油相的成分包括将初始组合物的pH值保持在5至9，优选在6-8范围内的缓冲溶液，（iii）任选地包含另外的两亲性非离子乳化剂和其它可溶的 /水混溶性赋形剂，其中水含量占组合物重量的50〜80％。
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3.发明公开Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制造方法，使用该化合物和药物组合物包含所述化合物
公开(公告)号：EP3061765A1
公开(公告)日：2016-08-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta
CPC分类号： C07J63/008
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
摘要翻译： 本发明涉及一种protoescigenin衍生物具有药理学性质，其制备方法，以及利用搜索化合物作为药物的爱尤其用于治疗血管疾病，以及涉及包含寻求化合物的药物组合物。
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4.发明授权Protoescigenin derivative, process of its preparation, use of said compound and pharmaceutical composition comprising that compound 有权Protoescigenin衍生物，其制备方法，所述化合物的用途以及包含该化合物的药物组合物
公开(公告)号：EP3061765B1
公开(公告)日：2018-01-31
申请号：EP15000566.8
申请日：2015-02-27
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Grynkiewicz, Grzegorz , Gruza, Mariusz Marek , Jatczak, Kamil , Filip, Katarzyna , Cmoch, Piotr , Laszcz, Marta , Dutkiewicz, Malgorzata
CPC分类号： C07J63/008 , A61K31/58
摘要： The present invention relates to a protoescigenin derivative having pharmacological properties, process of its preparation, use of such compound as medicament especially for treating vascular disorders, as well as to a pharmaceutical composition comprising such compound.
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5.发明公开HORSE CHESTNUT EXTRACT OR ESCINS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开EXTRAKT VONGEWÖHNLICHERROSSKASTANIE ODER AESCINS ZUR BEHANDLUNG冯ALZHEIMER-KRANKHEIT
公开(公告)号：EP3078381A1
公开(公告)日：2016-10-12
申请号：EP15001035.3
申请日：2015-04-10
申请人： Warszawski Uniwersytet Medyczny , INSTYTUT FARMACEUTYCZNY , Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
发明人： Koziak, Katarzyna , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Domanski, Dominik , Perzanowska, Anna
CPC分类号： A61K36/77
摘要： The subject invention relates to agents for use in treatment and/or prevention of Alzheimer's disease. The group of agents include horse chestnut extract, escins, their salts and derivatives.
摘要翻译： 本发明涉及用于治疗和/或预防阿尔茨海默病的药剂。 该组代理包括马蹄提取物，海鞘，其盐和衍生物。
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公开(公告)号：EP2939534A1
公开(公告)日：2015-11-04
申请号：EP14001527.2
申请日：2014-04-30
发明人： Koziak, Katarzyna , Bojakowski, Krzysztof , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Grabowska, Iwona , Surowiecka, Agnieszka
IPC分类号： A01K67/027 , A61K36/77
CPC分类号： A01K67/027 , A01K2207/30 , A01K2227/105 , A01K2267/0306 , A01K2267/0375
摘要： A non-human animal mammalian model for Parkes-Weber syndrome, wherein an animal has an arteriovenous fistula and a venous ligature in at least one of the limbs, is provided. The invention also relates to a method for preparing the model. The desired model reflects the pathophysiological characteristics of PW syndrome and can be used in studies on PW syndrome, including etiology of the syndrome. The animal model can also be used for screening a material for vascular use and for screening a preventive and/or therapeutic agent for Parkes-Weber syndrome.
摘要翻译： 提供了一种用于Parkes-Weber综合征的非人动物哺乳动物模型，其中动物在至少一个肢体中具有动静脉瘘和静脉结扎。 本发明还涉及一种用于制备该模型的方法。 所需模型反映了PW综合征的病理生理特征，可用于PW综合征的研究，包括综合征病因。 动物模型也可用于筛选用于血管使用的材料和筛选Parkes-Weber综合征的预防和/或治疗剂。
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公开(公告)号：EP3124016B1
公开(公告)日：2019-09-04
申请号：EP15460037.3
申请日：2015-07-31
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