公开(公告)号：EP2134738A1

公开(公告)日：2009-12-23

申请号：EP08742098.0

申请日：2008-03-14

申请人： Washington University ,  Beth Israel Deaconess Medical Center, Inc.

发明人： HUROV, Jonathan, B. ,  PIWNICA-WORMS, Helen ,  CANTLEY, Lewis, C.

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  C12N9/1205 ,  C12N2310/14 ,  C12Q1/485 ,  C12Y207/01037 ,  G01N2500/04 ,  G01N2800/042 ,  G01N2800/044

摘要： The invention relates to inhibition of Par- 1b kinase activity for treating disorders including diabetes and obesity. The invention also relates to screening for compounds or compositions that inhibit the kinase activity of Par- 1b protein, which compounds and compositions are useful in the treatment of diabetes and obesity, as well as preparing compounds for treatment of diabetes and obesity.

公开(公告)号：EP2076289B1

公开(公告)日：2014-11-12

申请号：EP08742861.1

申请日：2008-04-11

申请人： Dana-Farber Cancer Institute, Inc. ,  Beth Israel Deaconess Medical Center, Inc. ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： JANNE, Pasi, A. ,  ENGELMAN, Jeffrey ,  CANTLEY, Lewis, C.

IPC分类号： A61K45/06 ,  A61K39/395 ,  A61K31/517 ,  A61K31/404 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/404 ,  A61K31/517 ,  A61K39/395 ,  A61K45/06 ,  C12Q2600/106 ,  C12Q2600/156

公开(公告)号：EP1481093A2

公开(公告)日：2004-12-01

申请号：EP03735115.2

申请日：2003-02-03

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： CANTLEY, Lewis, C. ,  LAMIA, Katja, A. ,  RAMEH, Lucia ,  Kahn, Barbara,c/o Beth Israel Deaconess Med. ,  PERONI, Odile,Beth Israel Deaconess Med. Center

IPC分类号： C12Q1/68 ,  A01N43/04 ,  C07H21/04 ,  A61K31/07

CPC分类号： A61K49/0008 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A61K38/00 ,  C12N9/1205 ,  C12N15/8509 ,  C12Q1/485 ,  G01N33/573

摘要： The invention provides methods for modulating type IIβ phosphoinisitide phosphate kinase (PIPKIIβ) activity for treating PIPKIIβ-associated disorders. The invention also provides methods of identifying candidate agents for treating PIPKIIβ-associated disorders.

公开(公告)号：EP2054058A2

公开(公告)日：2009-05-06

申请号：EP07836571.5

申请日：2007-08-06

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： CANTLEY, Lewis, C. ,  VANDER HEIDEN, Matthew, G. ,  CHRISTOFK, Heather, R.

IPC分类号： A61K31/4184

CPC分类号： A61K31/4184 ,  A61K31/00 ,  A61K31/381 ,  A61K31/402 ,  A61K31/426

摘要： The invention provides pharmaceutical compositions, kits, and methods of treating cancer, diabetes, obesity, autoimmune disease, and benign prostatic hyperplasia using compounds that selectively inhibit pyruvate kinase M2 and an assay measuring chemical modulation of pyruvate kinase activity.

摘要翻译： 本发明提供了使用选择性抑制丙酮酸激酶M2的化合物和测量丙酮酸激酶活性的化学调节的测定来治疗癌症，糖尿病，肥胖症，自身免疫疾病和良性前列腺增生的药物组合物，试剂盒和方法。

公开(公告)号：EP1173755A2

公开(公告)日：2002-01-23

申请号：EP00926228.8

申请日：2000-04-21

申请人： Beth Israel Deaconess Medical Center, Inc.

发明人： VOLINIA, Stefano ,  LAI, Hung-Sen ,  YAFFE, Michael, B. ,  LEPAR, German, G. ,  CANTLEY, Lewis, C.

IPC分类号： G01N33/00

CPC分类号： G06F19/22 ,  G06F19/18

摘要： Method and apparatus for evaluating a query protein amino acid sequence with respect to an amino acid sequence motif corresponding to a target of a domain of a known protein having a known function to predict whether the query protein amino acid sequence performs the known function. In one embodiment, the prediction is performed by using a scoring system to generate a score for the query protein amino acid sequence with respect to the amino acid sequence motif. The score indicates a degree of confidence that the query protein amino acid sequence performs the known function. Several embodiments of scoring systems are described.