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公开(公告)号：EP2398919B1
公开(公告)日：2018-07-25
申请号：EP10744318.6
申请日：2010-02-18
发明人： CARLOCK, Leon , CYPHER, Maria
CPC分类号： C12N15/1086 , C12N15/01 , C12N15/67
摘要： The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to methods for identifying and isolating such cells, kits comprising the same, or methods which utilize different translational activities of these subpopulations of mammalian cells.
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2.发明公开METHOD FOR IDENTIFYING A SUBPOPULATION OF MAMMALIAN CELLS WITH DISTINCTIVE RIBOSOME TRANSLATION PROFILES 有权利用独特的核糖体翻译谱鉴定哺乳动物细胞亚群的方法
公开(公告)号：EP2398919A2
公开(公告)日：2011-12-28
申请号：EP10744318.6
申请日：2010-02-18
发明人： CARLOCK, Leon , CYPHER, Maria
CPC分类号： C12N15/1086 , C12N15/01 , C12N15/67
摘要： The present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to methods for identifying and isolating such cells, kits comprising the same, or methods which utilize different translational activities of these subpopulations of mammalian cells.
摘要翻译： 本发明一般涉及具有独特核糖体翻译谱，即翻译活性的哺乳动物细胞亚群。 本发明进一步涉及鉴定和分离这些细胞的方法，包含其的试剂盒或利用哺乳动物细胞的这些亚群的不同翻译活性的方法。
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公开(公告)号：EP3226846A1
公开(公告)日：2017-10-11
申请号：EP15865250.3
申请日：2015-12-03
发明人： CARLOCK, Leon , CYPHER, Maria
CPC分类号： G01N33/5011 , A61K31/23 , A61K31/35 , A61K31/366 , A61K31/4015 , A61K31/45 , A61K31/4725 , A61K45/06 , A61K49/0008 , C12N5/00 , C12N5/0693 , C12N2510/00 , C12Q1/6897 , G01N33/5017 , A61K2300/00
摘要： Methods and compositions for drug discovery, analysis and treatment of a proliferative disorder characterized by abnormal cells in a mammalian subject are provided according to aspects of the present invention which include administering a pharmaceutically effective amount of a combination of: a cytotoxic agent, a SET agonist and a SET ribosome antagonist. Methods and compositions according aspect of the present invention incorporate agents effective to regulate and/or affect selective translation in a cell characterized by abnormal proliferation, such as a cancer cell, thereby promoting death of the cell.
摘要翻译： 根据本发明的方面，提供了用于药物发现，分析和治疗以哺乳动物受试者中的异常细胞为特征的增殖性病症的方法和组合物，其包括施用药学有效量的细胞毒性剂，SET激动剂 和SET核糖体拮抗剂。 根据本发明的方面和组合物掺入有效调节和/或影响以异常增殖为特征的细胞如癌细胞中的选择性翻译从而促进细胞死亡的试剂。
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4.发明授权COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING CELL DEATH BY A TRANSLATION REGULATED GENE EXPRESSION SYSTEM 有权翻译调控基因表达系统检测和调控细胞死亡的组合物和方法
公开(公告)号：EP2185711B1
公开(公告)日：2017-05-10
申请号：EP08797373.1
申请日：2008-08-07
发明人： CARLOCK, Leon , CYPHER, Maria
CPC分类号： C12N15/85 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K48/00 , A61K48/0066 , C07K14/4713 , C12N7/00 , C12N15/86 , C12N2710/14043 , C12N2750/14143 , C12N2799/025 , C12N2799/026 , C12N2830/42 , C12N2840/00 , C12N2840/10 , C12N2840/203 , C12N2840/44 , C12N2840/85 , G01N33/5014 , G01N2333/90241 , G01N2510/00
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5.发明公开COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING CELL DEATH BY A TRANSLATION REGULATED GENE EXPRESSION SYSTEM 有权组合物和方法进行检测和细胞死亡的调节通过翻译调节的基因表达系统来
公开(公告)号：EP2185711A2
公开(公告)日：2010-05-19
申请号：EP08797373.1
申请日：2008-08-07
发明人： CARLOCK, Leon , CYPHER, Maria
CPC分类号： C12N15/85 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K48/00 , A61K48/0066 , C07K14/4713 , C12N7/00 , C12N15/86 , C12N2710/14043 , C12N2750/14143 , C12N2799/025 , C12N2799/026 , C12N2830/42 , C12N2840/00 , C12N2840/10 , C12N2840/203 , C12N2840/44 , C12N2840/85 , G01N33/5014 , G01N2333/90241 , G01N2510/00
摘要： The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the TR element, that is a first open reading frame (ORF) sequence and encodes a polypeptide or a fragment thereof and is co-translated with the TR element. The technology further relates to mammalian cells and a transgenic animal comprising such expression cassette. Further included are kits comprising the expression cassette, and methods for determining toxicity, and killing a target cell
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