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1.发明公开STEAROYL-COA DESATURASE TO IDENTIFY TRIGLYCERIDE REDUCING THERAPEUTIC AGENTS 有权硬脂酰COA脱氢酶一种判别TRIGLYCERIDREDUKTIONSTHERAPEUTIKA
公开(公告)号：EP1315831A2
公开(公告)日：2003-06-04
申请号：EP01920143.3
申请日：2001-02-23
发明人： BROWNLIE, Alison, J. , HAYDEN, Michael, R. , ATTIE, Alan, D. , NTAMBI, James, M. , GRAY-KELLER, Mark, P. , MIYAZAKI, Makoto
IPC分类号： C12Q1/26
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/201 , A61K31/426 , A61K31/4439 , A61K48/00 , C07K16/40 , C12N9/0083 , C12Q1/26 , G01N2333/90245 , Y10S514/866 , Y10S514/909
摘要： The use of screening assays based on the role of human stearoyl-CoA desaturase-1 ('hSCD1') in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids., wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
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2.发明授权STEAROYL-COA DESATURASE TO IDENTIFY TRIGLYCERIDE REDUCING THERAPEUTIC AGENTS 有权确定甘油三酯减少治疗药物的STEAROYL-COA DESATURASE
公开(公告)号：EP1315831B1
公开(公告)日：2010-07-28
申请号：EP01920143.3
申请日：2001-02-23
申请人： Xenon Pharmaceuticals Inc. , WISCONSIN ALUMNI RESEARCH FOUNDATION , UNIVERSITY OF BRITISH COLUMBIA
发明人： BROWNLIE, Alison, J. , HAYDEN, Michael, R. , ATTIE, Alan, D. , NTAMBI, James, M. , GRAY-KELLER, Mark, P. , MIYAZAKI, Makoto
IPC分类号： C12Q1/26
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/201 , A61K31/426 , A61K31/4439 , A61K48/00 , C07K16/40 , C12N9/0083 , C12Q1/26 , G01N2333/90245 , Y10S514/866 , Y10S514/909
摘要： The use of screening assays based on the role of human stearoyl-CoA desaturase-1 ('hSCD1') in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids., wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
摘要翻译： 基于人硬脂酰辅酶A去饱和酶-1（'hSCD1'）在与甘油三酯，VLDL，HDL，LDL，总胆固醇或血清中的分泌物产生相关的人类疾病，病症或病症中的作用的筛选测定的用途 粘膜，单不饱和脂肪酸，蜡酯等。 还公开了用于预防和/或治疗这些疾病的惯例。
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3.发明公开
公开(公告)号：EP1100895A2
公开(公告)日：2001-05-23
申请号：EP00917240.4
申请日：2000-03-15
IPC分类号： C12N15/12 , C07K14/705 , C12N5/10 , A01K67/027 , C12N15/00 , A61K38/17 , A61K48/00 , A61K38/45 , A61K31/00 , A61K31/70 , G01N33/68 , C12Q1/68 , C12N15/11
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/70567
摘要： The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
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公开(公告)号：EP1397385A2
公开(公告)日：2004-03-17
申请号：EP02732283.3
申请日：2002-06-07
IPC分类号： C07K14/705
CPC分类号： G01N33/689 , G01N33/6893 , G01N33/6896 , G01N2500/00
摘要： The invention features methods for treating, preventing or modulating a neurological disease or disorder, or for modulating an anaesthetic or a fertility process by administering compounds that modulate ABCA1 expression or activity. The invention also features methods for identifying compounds useful for such methods.
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5.发明公开COMPOSITIONS AND METHODS FOR MODULATING HDL CHOLESTEROL AND TRIGLYCERIDE LEVELS 审中-公开组合物和方法调制HDL胆固醇和甘油三酯
公开(公告)号：EP1239848A2
公开(公告)日：2002-09-18
申请号：EP00974705.6
申请日：2000-09-01
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K2039/53 , C07K14/70567
摘要： The invention features methods for treating patients having low HDL, a higher than normal triglyceride level, or a cardiovascular disease by administering compounds that modulate ABC1 expression or activity.
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6.发明授权STEAROYL-COA DESATURASE TO IDENTIFY TRIGLYCERIDE REDUCING THERAPEUTIC AGENTS 有权硬脂酰COA脱氢酶一种判别TRIGLYCERIDREDUKTIONSTHERAPEUTIKA
公开(公告)号：EP1315831B8
公开(公告)日：2010-09-01
申请号：EP01920143.3
申请日：2001-02-23
发明人： BROWNLIE, Alison, J. , HAYDEN, Michael, R. , ATTIE, Alan, D. , NTAMBI, James, M. , GRAY-KELLER, Mark, P. , MIYAZAKI, Makoto
IPC分类号： C12Q1/26
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/201 , A61K31/426 , A61K31/4439 , A61K48/00 , C07K16/40 , C12N9/0083 , C12Q1/26 , G01N2333/90245 , Y10S514/866 , Y10S514/909
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公开(公告)号：EP1227818A2
公开(公告)日：2002-08-07
申请号：EP00976795.5
申请日：2000-11-01
发明人： ATTIE, Alan, D. , COOK, Mark , GRAY-KELLER, Mark, P. , HAYDEN, Michael, R. , PIMSTONE, Simon , BROOKS-WILSON, Angie
IPC分类号： A61K31/64
CPC分类号： C12Q1/6883 , A61K31/64 , A61K49/0008 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044
摘要： Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
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8.发明公开
公开(公告)号：EP0873132A1
公开(公告)日：1998-10-28
申请号：EP96940479.0
申请日：1996-11-15
摘要： A protein, designated as HIP1, interacts differently with the gene product of a normal (16 CAG repeat) and an expanded (⊃ 44 CAG repeat) HD gene. The HIP1 protein originally isolated from the yeast two-hybrid screen is encoded by a 1.2 kb cDNA, devoid of stop codons, that is expressed as a 400 amino acid polypeptide. By further screening of a human frontal cortex cDNA library, and employing the protocol for 5' Rapid Amplification of cDNA ends (RACE), a total of 4795 nucleotides (with an open reading frame of 914 amino acids) of the 10 kb message HIP1 have been isolated to date. Expression of the HIP1 protein was found to be limited to the brain, where the interaction of the HIP1 with the HD protein appears to be necessary for the association of the HD protein with the membrane or specific cytoskeletal components to render it functional. Because HIP1 interacts with expanded HD protein less well than with normal length HD, introduction of additional HIP1 or overexpression of HIP-1 can lead to increased functionality of the defective or normal HD protein. Alternatively, modified forms of the HIP1 which bind more effectively to expanded HD could be introduced to convert the expanded HD protein into a functional molecule.
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公开(公告)号：EP1200117B1
公开(公告)日：2008-08-13
申请号：EP00943499.4
申请日：2000-06-23
CPC分类号： C12N9/20 , A61K38/00 , A61K48/00 , C12Y301/01034
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10.发明授权
公开(公告)号：EP1100895B1
公开(公告)日：2007-06-13
申请号：EP00917240.4
申请日：2000-03-15
IPC分类号： C12N15/12 , C07K14/705 , C12N5/10 , A01K67/027 , C12N15/00 , A61K38/17 , A61K48/00 , A61K38/45 , A61K31/00 , A61K31/70 , G01N33/68 , C12Q1/68 , C12N15/11
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/70567
摘要： The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
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