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1.发明公开PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS IN THE TREATMENT OF SKIN DISORDERS 审中-公开哒嗪衍生物及其用作治疗剂的皮肤疾病的治疗
公开(公告)号：EP2257291A2
公开(公告)日：2010-12-08
申请号：EP09713747.5
申请日：2009-02-19
发明人： BILLICH, Andreas , WINTHER, Michael, D. , GOLDBERG, Yigal, Paul , WINZENBURG, Gesine , RAPP, Karin , FRITZE, Andreas
IPC分类号： A61K31/501 , A61P17/00 , A61P17/08 , A61P17/10 , A61K9/00 , A61K47/08 , A61K47/10 , A61K47/32
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D473/00
摘要： Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human, including administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R
2 , R
3 , R
4 , R
5 , R
6 , R
6a , R
7 , R
7a , R
8 , R
8a , R
9 and R
9a are defined herein, and compositions including a compound of formula (I).-
2.发明公开TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N-[6-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-3-PYRIDINYL]-2-METHYL-41-(TRIFLUOROMETHOXY)-[1,1'-BIPHENYL]-3-CARBOXAMIDE. 有权WITH局部药物组合物REL-N- [6 - [（2R，6S）-2,6-二甲基-4-吗啉基] -3-吡啶基] -2-甲基-4 ' - （三氟甲氧基） - [1,1' 联苯] -3-甲酰胺
公开(公告)号：EP2456422A2
公开(公告)日：2012-05-30
申请号：EP10733012.8
申请日：2010-07-20
申请人： Novartis AG
IPC分类号： A61K9/00 , A61K31/5377 , A61K47/10 , A61K47/14 , A61K47/26
CPC分类号： A61K9/0014 , A61K31/5377 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The present invention relates to pharmaceutics compositions of 2-Methyl-4'- trifluoromethoxy-biphenyl-3-carboxylic acid [6-{cis-2,6-dimethyl-morpholin-4-yl)-pyridlin-3-yl]- amide, to the use of such compositions in therapeutic applications and to methods for manufacturing such compositions.
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3.发明授权TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING REL-N-[6-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-3-PYRIDINYL]-2-METHYL-4'-(TRIFLUOROMETHOXY)-[1,1'-BIPHENYL]-3-CARBOXAMIDE. 有权WITH局部药物组合物REL-N- [6 - [（2R，6S）-2,6-二甲基-4-吗啉基] -3-吡啶基] -2-甲基-4 ' - （三氟甲氧基） - [1,1' 联苯] -3-甲酰胺
公开(公告)号：EP2456422B1
公开(公告)日：2016-03-16
申请号：EP10733012.8
申请日：2010-07-20
申请人： Novartis AG
IPC分类号： A61K9/00 , A61K31/5377 , A61K47/10 , A61K47/14 , A61K47/26
CPC分类号： A61K9/0014 , A61K31/5377 , A61K47/10 , A61K47/14 , A61K47/26
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