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1.发明公开PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS IN THE TREATMENT OF SKIN DISORDERS 审中-公开哒嗪衍生物及其用作治疗剂的皮肤疾病的治疗
公开(公告)号：EP2257291A2
公开(公告)日：2010-12-08
申请号：EP09713747.5
申请日：2009-02-19
发明人： BILLICH, Andreas , WINTHER, Michael, D. , GOLDBERG, Yigal, Paul , WINZENBURG, Gesine , RAPP, Karin , FRITZE, Andreas
IPC分类号： A61K31/501 , A61P17/00 , A61P17/08 , A61P17/10 , A61K9/00 , A61K47/08 , A61K47/10 , A61K47/32
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D473/00
摘要： Methods of treating an SCD-mediated skin disorder or condition in a mammal, preferably a human, including administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R
2 , R
3 , R
4 , R
5 , R
6 , R
6a , R
7 , R
7a , R
8 , R
8a , R
9 and R
9a are defined herein, and compositions including a compound of formula (I).-
公开(公告)号：EP1651620B1
公开(公告)日：2011-11-09
申请号：EP04779656.0
申请日：2004-07-29
发明人： SVIRIDOV, Serguei , KODUMURU, Vishnumurthy , LIU, Shifeng , ABREO, Melwyn , WINTHER, Michael, D. , GSCHWEND, Heinz, W. , KAMBOJ, Rajender , SUN, Shaoyi , HOLLADAY, Mark, W. , LI, Wenbao , TU, Chi
IPC分类号： C07D239/42
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651605A2
公开(公告)日：2006-05-03
申请号：EP04779556.2
申请日：2004-07-29
发明人： ABREO, Melwyn , HARVEY, Daniel, F. , KONDRATENKO, Mikhail, A. , LI, Wenbao , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , WINTHER, Michael, D. , GSCHWEND, Heinz, W. , CHAKKA, Nagasree , LIU, Shifeng , SVIRIDOV, Serguei , SUN, Shaoyi
IPC分类号： C07D213/71
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1851205B1
公开(公告)日：2012-04-11
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651620A2
公开(公告)日：2006-05-03
申请号：EP04779656.0
申请日：2004-07-29
发明人： SVIRIDOV, Serguei , KODUMURU, Vishnumurthy , LIU, Shifeng , ABREO, Melwyn , WINTHER, Michael, D. , GSCHWEND, Heinz, W. , KAMBOJ, Rajender , SUN, Shaoyi , HOLLADAY, Mark, W. , LI, Wenbao , TU, Chi
IPC分类号： C07D239/42
CPC分类号： A61K31/551 , A61K31/00 , A61K31/501 , C07D237/20 , C07D403/08 , C07D405/08 , C07D409/12 , C07D413/08
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651606B1
公开(公告)日：2012-10-24
申请号：EP04779655.2
申请日：2004-07-29
发明人： ABREO, Melwyn , HARVEY, Daniel, F. , GSCHWEND, Heinz, W. , LI, Wenbao , TU, Chi , KAMBOJ, Rajender , WINTHER, Michael, D. , KODUMURU, Vishnumurthy , HUDSON, Cindy, J. , KONDRATENKO, Mikhail, A. , LIU, Shifeng , RAINA, Vandna , SVIRIDOV, Serguei , ZHANG, Zaihui , SEID BAGHERZADEH, Mehran , SUN, Shaoyi
IPC分类号： C07D213/75
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
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公开(公告)号：EP1763350A1
公开(公告)日：2007-03-21
申请号：EP04756752.4
申请日：2004-07-06
发明人： FU, Jian-Min , KODUMURU, Vishnumurthy , SUN, Shaoyi , WINTHER, Michael, D. , FINE, Richard, M. , HARVEY, Daniel, F. , KLEBANSKY, Boris , GRAY-KELLER, Mark , GSCHWEND, Heinz, W.
IPC分类号： A61K31/496 , C07D401/00 , A61P43/00 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/496
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1651605B1
公开(公告)日：2012-05-02
申请号：EP04779556.2
申请日：2004-07-29
发明人： ABREO, Melwyn , HARVEY, Daniel, F. , KONDRATENKO, Mikhail, A. , LI, Wenbao , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , WINTHER, Michael, D. , GSCHWEND, Heinz, W. , CHAKKA, Nagasree , LIU, Shifeng , SVIRIDOV, Serguei , SUN, Shaoyi
IPC分类号： C07D213/71
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1763350B1
公开(公告)日：2011-12-21
申请号：EP04756752.4
申请日：2004-07-06
发明人： FU, Jian-Min , KODUMURU, Vishnumurthy , SUN, Shaoyi , WINTHER, Michael, D. , FINE, Richard, M. , HARVEY, Daniel, F. , KLEBANSKY, Boris , GRAY-KELLER, Mark , GSCHWEND, Heinz, W. , LI, Wenbao
IPC分类号： A61K31/496 , C07D401/00 , A61P43/00 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/496
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1851205A2
公开(公告)日：2007-11-07
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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