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公开(公告)号：EP2147926B1
公开(公告)日：2016-08-24
申请号：EP08748432.5
申请日：2008-04-29
发明人： Li, Shaowei , SHEN, Wentong , LI, Zhongyi , XIE, Minghui , PAN, Huirong , XIA, Ningshao
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20011 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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2.发明公开TRUNCATED HUMAN PAPILLOMAVIRUS TYPE 18 L1 PROTEINS 有权TRUNKIERTE L1-PROTEINE DES HUMANEN PAPILLOMAVIRUS TYP 18
公开(公告)号：EP2147926A1
公开(公告)日：2010-01-27
申请号：EP08748432.5
申请日：2008-04-29
发明人： Li, Shaowei , SHEN, Wentong , LI, Zhongyi , XIE, Minghui , PAN, Huirong , XIA, Ningshao
CPC分类号： A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20011 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 18, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of cervical caner.
摘要翻译： 本发明涉及人乳头瘤病毒18型的截短的L1蛋白，由蛋白组成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及在预防宫颈癌中使用该疫苗。
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公开(公告)号：EP2154149A1
公开(公告)日：2010-02-17
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/025 , C12N7/00 , C12N2700/00 , C12N2710/00 , C12N2710/20022 , C12N2710/20034 , C12P21/00 , G01N2333/025
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
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公开(公告)号：EP2154149B1
公开(公告)日：2019-07-10
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
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公开(公告)号：EP3981782A1
公开(公告)日：2022-04-13
申请号：EP21194967.2
申请日：2016-05-20
发明人： GE, Shengxiang , LI, Tingdong , JIA, Lianzhi , LI, Yijian , XUE, Miaoge , ZENG, Yuanjun , ZHANG, Jun , XIA, Ningshao , PAN, Huirong
摘要： The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.
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6.发明公开TRUNCATED HUMAN PAPILLOMAVIRUS TYPE 33 PROTEIN L1 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS VOM TYP 33
公开(公告)号：EP2716653A1
公开(公告)日：2014-04-09
申请号：EP12788749.5
申请日：2012-05-22
发明人： LI, Shaowei , KONG, Xianglin , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/04 , C07K1/16 , C07K1/30 , A61K39/12 , A61P31/20 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to a truncated L1 protein of Human Papillomavirus (HPV) Type 33, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein and the virus-like particle are useful for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer. The invention also relates to the use of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer.
摘要翻译： 本发明涉及33型人乳头状瘤病毒（HPV）的截短的L1蛋白，其编码序列，其制备方法以及包含其的病毒样颗粒，其中蛋白质和病毒样颗粒 可用于预防HPV（特别是HPV33）感染，以及由HPV（特别是HPV33）感染引起的疾病，如宫颈癌。 本发明还涉及蛋白质和病毒样颗粒在制备用于预防HPV（特别是HPV33）感染的药物组合物或疫苗以及由HPV（特别是HPV33）感染引起的疾病如宫颈癌中的用途 癌症。
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公开(公告)号：EP2716653B1
公开(公告)日：2017-04-19
申请号：EP12788749.5
申请日：2012-05-22
发明人： LI, Shaowei , KONG, Xianglin , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/04 , C07K1/16 , C07K1/30 , A61K39/12 , A61P31/20 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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8.发明公开TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS VOM TYP 52
公开(公告)号：EP2589604A1
公开(公告)日：2013-05-08
申请号：EP11800199.9
申请日：2011-07-01
发明人： LI, Shaowei , MO, Xiaobing , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/70 , C12N1/21 , A61K39/12 , A61P31/20
CPC分类号： C07K14/025 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20051 , C12P21/02
摘要： Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.
摘要翻译： 提供了52型人乳头瘤病毒（HPV）的截短L1蛋白，与野生型HPV52 L1蛋白相比，在N-末端被27-42个氨基酸截短。 还提供了截短的HPV52 L1蛋白的编码序列，包含蛋白质的病毒样颗粒（VLP），以及使用大肠杆菌表达系统制备蛋白质和VLP的方法。 截短的HPV52 L1蛋白和组装的VLP可用于预防HPV52感染和HPV52感染引起的疾病，如宫颈癌。
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公开(公告)号：EP2589604B1
公开(公告)日：2016-10-05
申请号：EP11800199.9
申请日：2011-07-01
发明人： LI, Shaowei , MO, Xiaobing , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/70 , C12N1/21 , A61K39/12 , A61P31/20
CPC分类号： C07K14/025 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20051 , C12P21/02
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