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公开(公告)号：EP3617317A1
公开(公告)日：2020-03-04
申请号：EP18754095.0
申请日：2018-02-05
发明人： ZHANG, Tianying , YUAN, Quan , GUO, Xueran , WEI, Minxi , KANG, Xiaozhen , ZHANG, Jun , XIA, Ningshao
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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2.发明公开TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS VOM TYP 52
公开(公告)号：EP2589604A1
公开(公告)日：2013-05-08
申请号：EP11800199.9
申请日：2011-07-01
发明人： LI, Shaowei , MO, Xiaobing , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/70 , C12N1/21 , A61K39/12 , A61P31/20
CPC分类号： C07K14/025 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20051 , C12P21/02
摘要： Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.
摘要翻译： 提供了52型人乳头瘤病毒（HPV）的截短L1蛋白，与野生型HPV52 L1蛋白相比，在N-末端被27-42个氨基酸截短。 还提供了截短的HPV52 L1蛋白的编码序列，包含蛋白质的病毒样颗粒（VLP），以及使用大肠杆菌表达系统制备蛋白质和VLP的方法。 截短的HPV52 L1蛋白和组装的VLP可用于预防HPV52感染和HPV52感染引起的疾病，如宫颈癌。
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3.发明公开TRUNCATED HUMAN PAPILLOMAVIRUS TYPE 58 L1 PROTEIN 有权TRUNKIERTE L1-PROTEINE DES HUMANEN PAPILLOMAVIRUS TYP 58
公开(公告)号：EP2594579A1
公开(公告)日：2013-05-22
申请号：EP11806304.9
申请日：2011-07-15
发明人： LI, Shaowei , WEI, Minxi , KONG, Xianglin , WANG, Yingbin , ZHANG, Jun , XIA, Ningshao
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.
摘要翻译： 提供人类乳头瘤病毒58型的N-末端截短的L1蛋白，其编码序列及其制备方法和包含该蛋白质的病毒样颗粒。 还提供了蛋白质和病毒样颗粒在制备药物组合物或疫苗中的用途。 药物组合物或疫苗用于预防HPV感染和HPV感染引起的疾病。
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公开(公告)号：EP2589604B1
公开(公告)日：2016-10-05
申请号：EP11800199.9
申请日：2011-07-01
发明人： LI, Shaowei , MO, Xiaobing , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/70 , C12N1/21 , A61K39/12 , A61P31/20
CPC分类号： C07K14/025 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20051 , C12P21/02
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公开(公告)号：EP2154147B1
公开(公告)日：2015-10-07
申请号：EP08748431.7
申请日：2008-04-29
发明人： GU, Ying , LI, Shaowei , WEI, Minxi , XIAN, Yangling , LUO, Wenxin , XIA, Ningshao
IPC分类号： C12N7/02 , C07K14/025 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2710/20022 , C12N2710/20034
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公开(公告)号：EP2716653B1
公开(公告)日：2017-04-19
申请号：EP12788749.5
申请日：2012-05-22
发明人： LI, Shaowei , KONG, Xianglin , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/04 , C07K1/16 , C07K1/30 , A61K39/12 , A61P31/20 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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公开(公告)号：EP2594579B1
公开(公告)日：2015-04-15
申请号：EP11806304.9
申请日：2011-07-15
发明人： LI, Shaowei , WEI, Minxi , KONG, Xianglin , WANG, Yingbin , ZHANG, Jun , XIA, Ningshao
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.
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8.发明公开TRUNCATED HUMAN PAPILLOMAVIRUS TYPE 33 PROTEIN L1 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS VOM TYP 33
公开(公告)号：EP2716653A1
公开(公告)日：2014-04-09
申请号：EP12788749.5
申请日：2012-05-22
发明人： LI, Shaowei , KONG, Xianglin , WEI, Minxi , PAN, Huirong , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/04 , C07K1/16 , C07K1/30 , A61K39/12 , A61P31/20 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The present invention relates to a truncated L1 protein of Human Papillomavirus (HPV) Type 33, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein and the virus-like particle are useful for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer. The invention also relates to the use of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine for preventing HPV (particularly HPV33) infection, and a disease caused by HPV (particularly HPV33) infection, such as cervical cancer.
摘要翻译： 本发明涉及33型人乳头状瘤病毒（HPV）的截短的L1蛋白，其编码序列，其制备方法以及包含其的病毒样颗粒，其中蛋白质和病毒样颗粒 可用于预防HPV（特别是HPV33）感染，以及由HPV（特别是HPV33）感染引起的疾病，如宫颈癌。 本发明还涉及蛋白质和病毒样颗粒在制备用于预防HPV（特别是HPV33）感染的药物组合物或疫苗以及由HPV（特别是HPV33）感染引起的疾病如宫颈癌中的用途 癌症。
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9.发明公开A TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16 有权GEKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS 16
公开(公告)号：EP2154147A1
公开(公告)日：2010-02-17
申请号：EP08748431.7
申请日：2008-04-29
发明人： GU, Ying , LI, Shaowei , WEI, Minxi , XIAN, Yangling , LUO, Wenxin , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N7/02 , C07K1/18 , A61K39/12 , A61P31/20 , A61P15/02 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 16, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of cervical caner.
摘要翻译： 本发明涉及16型人乳头瘤病毒的截短L1蛋白，由蛋白质构成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防宫颈癌中的用途。
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